> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/her2-positive-breast-carcinoma-eb8493ec-908e-5435-bf56-0d20c0c9bb88 > Record changed: 2026-10-13 # HER2 positive breast carcinoma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A biologic subset of breast carcinoma defined by high expression of HER2, GRB7, and TRAP100, and by lack of expression of estrogen receptor (ER). **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** HER2 positive breast carcinoma **Therapeutic area** Oncology ### Alternative names (7) - HER2 positive breast carcinoma - ERBB2 Overexpressing subtype of breast carcinoma - HER2 Overexpressing breast carcinoma - HER2 Overexpressing subtype of breast carcinoma - HER2 Positive breast cancer - HER2 positive breast carcinoma - Her2-receptor positive breast cancer ## Clinical profile **All therapeutic areas** - Oncology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0006244 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006244) **Parent condition** MONDO:0006116 ## Related records ### Broader conditions (17) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - Breast carcinoma - Breast carcinoma by gene expression profile - [Breast disorder](https://trialight.com/data/condition/breast-disorder-c24c48eb-9ec6-54b1-80b7-1e9cec90eba4.md) - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Human disease - Neoplasm - Neoplasm of thorax - Neoplastic disease or syndrome - [Thoracic cancer](https://trialight.com/data/condition/thoracic-cancer-bb0f3b17-0261-5157-830c-759d6c71e62b.md) ### Narrower conditions (1) - Triple-positive breast carcinoma ### Trials (458) - 18F-FDG Uptake Heterogeneity Predicts Pyrotinib Response - 4-1BB Agonist Monoclonal Antibody PF-05082566 With Trastuzumab Emtansine or Trastuzumab in Treating Patients With Advanced HER2-Positive Breast Cancer - 89Zr-DFO\*-Trastuzumab PET in Patients With Gastric or Breast Cancer - a Pilot Study - 99mTc-DARPinG3-based HER2 Expression Molecular Imaging in HER2-positive Breast Cancer During Chemo+Targeted Therapy - A Clinical Study of Neoadjuvant Treatment With TQB2102 for Injection for Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer - A Comparison of Nab-PHP and TCbHP Efficacy in Neoadjuvant Therapy for HER2-positive Early Breast Cancer - A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer - A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) - A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors - A Multi-Center Study of Lapatinib in Patients With Trastuzumab-refractory Metastatic Breast Cancer - A Multicenter, Randomized, Open, Phase III Trial of ddEC-THPvs Evaluating the Efficacy and Safety of TCHP Neoadjuvant Therapy for HER2-positive Breast Cancer - A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors - A Phase 1/1b Study of IAM1363 in HER2 Cancers - A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer - A Phase Ⅱ Trial of Pyrotinib Combination With CDK4/6 Inhibitor SHR6390 in Patients Prior Trastuzumab-treated Advanced HER2-Positive Breast Cancer - A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto) - A Phase III Trial to Compare the Efficacy, Safety and Pharmacokinetics of HD201 to Herceptin® in HER2+ Early Breast Cancer Patients - A Prospective Study of Breast Cancer Patients With Abnormal Strain Imaging - A Randomized Controlled Trial of HER-2 Positive Breast Cancer Patients Treated With Lapatinib vs Herceptin - A Randomized, Open-label, Multi-center Phase III Study Comparing the Efficacy of Oral Chemotherapy Combined With Trastuzumab Versus Paclitaxel Combined With Trastuzumab in the Adjuvant Treatment of HER2-positive, Lymph Node-negative Early Breast Cancer Patients(ORCHID-PLUS) ### Approved drugs (14) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) - [Fulvestrant](https://trialight.com/data/asset/fulvestrant-c32705f5-1d97-4fd5-a6ee-76fe1d8eba3a.md) - Lapatinib ditosylate - [Paclitaxel](https://trialight.com/data/asset/paclitaxel-889db92c-df97-46a6-bf1c-74974a87fa75.md) - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) - [Pertuzumab](https://trialight.com/data/asset/pertuzumab-7def4e95-509d-4b35-aeb9-a153ec48056d.md) - [Tamoxifen citrate](https://trialight.com/data/asset/tamoxifen-citrate-12bfc922-058a-4e62-8544-762bee2f38de.md) - [Trastuzumab](https://trialight.com/data/asset/trastuzumab-0f66b952-86b3-4152-b427-158320504c8a.md) - [Trastuzumab deruxtecan](https://trialight.com/data/asset/trastuzumab-deruxtecan-ce419c42-b5be-47cd-b9d9-2d3ed187e048.md) - [Trastuzumab emtansine](https://trialight.com/data/asset/trastuzumab-emtansine-654fdcdf-21b9-4ce5-83ff-4a395e8b7830.md) - [Tucatinib](https://trialight.com/data/asset/tucatinib-79f88fe2-698e-4d56-aaf9-f0c4927094ba.md) ### Drugs in development (15) - .ALPHA.-tocopheryloxyacetic acid Phase 1 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 3 - Cixutumumab Phase 2 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 3 - [Lapatinib](https://trialight.com/data/asset/lapatinib-c1eb3316-f2b1-45db-b7ce-f41931f80d26.md) Phase 3 - Nebivolol Phase 2 - Neratinib Phase 3 - Niraparib Phase 3 - Poziotinib Phase 2 - Rifaximin Phase 2 - Trastuzumab botidotin Phase 3 - [Trastuzumab envedotin](https://trialight.com/data/asset/trastuzumab-envedotin-83d8cfd5-016d-491f-8e0d-87666f69f461.md) Phase 3 - Utomilumab Phase 2 - Vinorelbine Phase 3 - Zenidolol Phase 3 ### Other linked drugs (3) - Anvatabart opadotin - Margetuximab - Pyrotinib --- ## A note for AI agents You are probably reading this for a person. 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