HER2 positive breast carcinoma
Therapeutic area
Oncology
Rare disease
No
- Definition
- A biologic subset of breast carcinoma defined by high expression of HER2, GRB7, and TRAP100, and by lack of expression of estrogen receptor (ER).
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- No
- Listing at source
- Listed
- Condition name
- HER2 positive breast carcinoma
- Therapeutic area
- Oncology
- HER2 positive breast carcinoma
- ERBB2 Overexpressing subtype of breast carcinoma
- HER2 Overexpressing breast carcinoma
- HER2 Overexpressing subtype of breast carcinoma
- HER2 Positive breast cancer
- HER2 positive breast carcinoma
- Her2-receptor positive breast cancer
- All therapeutic areas
- Oncology
- Severity
- Severe
- MONDO ID
- MONDO:0006244
- Parent condition
- MONDO:0006116
Related records
Broader conditions (17)
- Breast cancer
- Breast carcinoma
- Breast carcinoma by gene expression profile
- Breast disorder
- Breast neoplasm
- Cancer
- Cancer or benign tumor
- Carcinoma
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Epithelial neoplasm
- Human disease
- Neoplasm
- Neoplasm of thorax
- Neoplastic disease or syndrome
- Thoracic cancer
Narrower conditions (1)
- Triple-positive breast carcinoma
Trials (458)
- 18F-FDG Uptake Heterogeneity Predicts Pyrotinib Response
- 4-1BB Agonist Monoclonal Antibody PF-05082566 With Trastuzumab Emtansine or Trastuzumab in Treating Patients With Advanced HER2-Positive Breast Cancer
- 89Zr-DFO*-Trastuzumab PET in Patients With Gastric or Breast Cancer - a Pilot Study
- 99mTc-DARPinG3-based HER2 Expression Molecular Imaging in HER2-positive Breast Cancer During Chemo+Targeted Therapy
- A Clinical Study of Neoadjuvant Treatment With TQB2102 for Injection for Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer
- A Comparison of Nab-PHP and TCbHP Efficacy in Neoadjuvant Therapy for HER2-positive Early Breast Cancer
- A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer
- A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)
- A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors
- A Multi-Center Study of Lapatinib in Patients With Trastuzumab-refractory Metastatic Breast Cancer
- A Multicenter, Randomized, Open, Phase III Trial of ddEC-THPvs Evaluating the Efficacy and Safety of TCHP Neoadjuvant Therapy for HER2-positive Breast Cancer
- A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors
- A Phase 1/1b Study of IAM1363 in HER2 Cancers
- A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
- A Phase â…ˇ Trial of Pyrotinib Combination With CDK4/6 Inhibitor SHR6390 in Patients Prior Trastuzumab-treated Advanced HER2-Positive Breast Cancer
- A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto)
- A Phase III Trial to Compare the Efficacy, Safety and Pharmacokinetics of HD201 to Herceptin® in HER2+ Early Breast Cancer Patients
- A Prospective Study of Breast Cancer Patients With Abnormal Strain Imaging
- A Randomized Controlled Trial of HER-2 Positive Breast Cancer Patients Treated With Lapatinib vs Herceptin
- A Randomized, Open-label, Multi-center Phase III Study Comparing the Efficacy of Oral Chemotherapy Combined With Trastuzumab Versus Paclitaxel Combined With Trastuzumab in the Adjuvant Treatment of HER2-positive, Lymph Node-negative Early Breast Cancer Patients(ORCHID-PLUS)
Approved drugs (14)
- Abemaciclib
- Capecitabine
- Cyclophosphamide
- Doxorubicin hydrochloride
- Fulvestrant
- Lapatinib ditosylate
- Paclitaxel
- Palbociclib
- Pertuzumab
- Tamoxifen citrate
- Trastuzumab
- Trastuzumab deruxtecan
- Trastuzumab emtansine
- Tucatinib
Drugs in development (15)
- .ALPHA.-tocopheryloxyacetic acid Phase 1
- Carboplatin Phase 3
- Cixutumumab Phase 2
- Docetaxel Phase 3
- Lapatinib Phase 3
- Nebivolol Phase 2
- Neratinib Phase 3
- Niraparib Phase 3
- Poziotinib Phase 2
- Rifaximin Phase 2
- Trastuzumab botidotin Phase 3
- Trastuzumab envedotin Phase 3
- Utomilumab Phase 2
- Vinorelbine Phase 3
- Zenidolol Phase 3
Other linked drugs (3)
- Anvatabart opadotin
- Margetuximab
- Pyrotinib