> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/hemophilia-a-f8870901-8872-5178-8d5a-e1fde5d3339e > Record changed: 2026-10-13 # Hemophilia A Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** The most common form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor VIII deficiency. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Hemophilia A **Therapeutic area** Hematology ### Alternative names (23) - hemophilia A - congenital factor VIII disorder - factor VIII deficiency - haemophilia a, X-linked recessive - haemophilia type A - haemophilia type a - hemophilia A - hemophilia a, X-linked recessive - hemophilia type A - hemophilia type a - hereditary Factor VIII deficiency - hereditary Factor VIII deficiency disease - HEMA - Haemophilia A - autosomal haemophilia a - classic haemophilia - classic hemophilia - classical haemophilia - classical hemophilia - factor 8 deficiency - haemophilia A, congenital - hem A - hemophilia A, congenital ## Clinical profile **All therapeutic areas** - Hematology **Severity** Severe ### Disease mechanisms (2) - Genetic - Hereditary ## Identifiers **MONDO ID** MONDO:0010602 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0010602) **Parent condition** MONDO:0000425 ## Related records ### Broader conditions (13) - Blood coagulation disease - Coagulation protein disease - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Hematologic disorder - Hemophilia - Hemorrhagic disease - Hereditary disease - Human disease - Inherited blood coagulation disorder - X-linked disease ### Narrower conditions (5) - Hemophilia A with vascular abnormality - Mild hemophilia A - Moderately severe hemophilia A - Severe hemophilia A - Symptomatic form of hemophilia A in female carriers ### Trials (789) - 2-cohort Study of Adult Patients With Severe Hemophilia A in Greece - 3D Ultrasound in Hemophilic Ankles - A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health - A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children - A Clinical Study of Recombinant Human Coagulation Factor VIII for Injection in Patients With Severe Hemophilia A - A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A - A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A - A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B - A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors - A Feasibility Study to Collect Data in Patients With Haemophilia - A First-in Human Study of ARD001 in Healthy Volunteers and People With Hemophilia A - A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A - A Gene Transfer Study for Hemophilia A - A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401) - A Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia A - A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia A - A Multi-centre, Open Labelled, Multiple Dosing Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC 0172-2021 Administered Subcutaneously to Healthy Male Subjects and Haemophilia Subjects - A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously Treated Paediatric Patients With Severe Haemophilia A - A Non-interventional Retrospective Study of the Current Treatment Practice in European Haemophilia Care - A Pharmacokinetic and Clotting Activity Study of FVIII-PEGLip ### Approved drugs (19) - Antihemophilic factor, pegylated (MW 20000) human sequence recombinant - Damoctocog alfa pegol - Efanesoctocog alfa - Efmoroctocog alfa - Emicizumab - Eptacog alfa (activated) - Eptacog beta (activated) - Human coagulation factor VIII - Lonoctocog alfa - Marstacimab - Moroctocog alfa - Octocog alfa - Simoctocog alfa - Susoctocog alfa - Tranexamic acid - Turoctocog alfa - Turoctocog alfa pegol - Valoctocogene roxaparvovec - Von willebrand factor human ### Drugs in development (18) - Anti-inhibitor coagulant complex Phase 3 - Antithrombin III human Phase 3 - Ataluren Phase 2 - BAY-1093884 Phase 2 - Concizumab Phase 3 - [Denecimig](https://trialight.com/data/asset/denecimig-6c082e13-91b6-4504-abfd-41125b68d81f.md) Phase 1 - Dirloctocogene samoparvovec Phase 1 - Eptacog alfa pegol (activated) Phase 1 - Fitusiran Phase 3 - Giroctocogene fitelparvovec Phase 3 - Marzeptacog alfa (activated) Phase 1 - Omfiloctocog alfa Phase 3 - Oprelvekin Phase 2 - [Prednisone](https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6.md) Phase 2 - [Rituximab](https://trialight.com/data/asset/rituximab-3fb73477-f618-414e-aa0a-9ccba4d6da3f.md) Phase 2 - Rondaptivon pegol Phase 1 - Thrombin Phase 2 - Vatreptacog alfa (activated) Phase 2 ### Other linked drugs (1) - Desmopressin --- ## A note for AI agents You are probably reading this for a person. 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