> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc > Record changed: 2026-10-13 # Heart failure Therapeutic area Cardiology Rare disease No ## Definition and classification **Definition** Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Heart failure **Therapeutic area** Cardiology ### Alternative names (6) - heart failure - cardiac failure - cardiac insufficiency - failure, heart - heart failure - insufficiency, Cardiac ## Clinical profile **All therapeutic areas** - Cardiology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0005252 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005252) **Parent condition** MONDO:0005267 ## Related records ### Broader conditions (5) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Disease - Disease by body system or component - Heart disorder - Human disease ### Narrower conditions (16) - Acute cor pulmonale - Advanced heart failure - Cardio-renal syndrome - Chronic pulmonary heart disease - Congestive heart failure - Cor pulmonale - [Diastolic heart failure](https://trialight.com/data/condition/diastolic-heart-failure-b3fbecba-f0d5-5a66-ac3b-8843d29791ea.md) - High output heart failure - Idiopathic pulmonary arterial hypertension - Kyphoscoliotic heart disease - Left ventricular failure - Mild heart failure - Moderate heart failure - Rheumatic congestive heart failure - Symptomatic heart failure - Systolic heart failure ### Trials (5,545) - : Vascular Function in Health and Disease - " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " - "A Nurse-led Motivational Interviewing Tailored Intervention for Improving Self Care Behaviours and Health Outcomes in Heart Failure Patients in Oman - "ALOFT - Aliskiren Observation of Heart Failure Treatment": Efficacy and Safety of Aliskiren Added on Top of Standard Therapy in Adults (≥ 18 Years) With Stable Heart Failure - "De Novo" Atrial Fibrillation in Patients With Heart Failure: Incidence; Predictors and Relevance. - "ESTIMATION Study" for Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction - "HerzCheck" - Detection of Early Heart Failure Using Telemedicine in Structurally Weak Regions - "Hub and Satellite" Heart Failure Provider's Network Study - "The Effect of Sleep Hygiene Training Given to Heart Failure Patients on Their HospitalAcquired Insomnia Level" - 1 Year Post Discharge Prognostic Model From the National Heart Failure Audit (NHFA) - 123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging on a Small Field of View-High Efficiency Cardiac SPECT System - 123I-mIBG SPECT Imaging - 18F-mFBG Imaging for Myocardial Sympathetic Innervation - 3/7 Resistance Training Method in Cardiac Rehabilitation - 30 Days and 90 Days Heart Failure Re-Admission at Komfo Anokye Teaching Hospital - 3D Assessment of RV Function in Patients Undergoing LVAD Implantation - ⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure - A CALIBER Study: Risk Factors for Stroke, Heart Failure, and Myocardial Infarction in Atrial Fibrillation - A Clinical Follow-up Study of Heart Failure Patients. - A Clinical Study Assessing the Potential of Piboserod for the Treatment of Heart Failure ### Approved drugs (42) - Acetazolamide - [Alteplase](https://trialight.com/data/asset/alteplase-89461f67-4f40-4a00-ae4c-727752018887.md) - Amlodipine besylate - Atorvastatin calcium - Bumetanide - Candesartan cilexetil - Captopril - Carvedilol - Chlorothiazide - Chlorthalidone - Conivaptan hydrochloride - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) - Dapagliflozin propanediol - [Digoxin](https://trialight.com/data/asset/digoxin-9928e38a-813e-4948-9d65-9088ba40a442.md) - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) - Enalapril maleate - Eplerenone - Fosinopril sodium - Furosemide ### Drugs in development (194) - Acipimox Phase 2 - Aladorian Phase 2 - Alagebrium chloride Phase 2 - Albuterol Phase 3 - Aliskiren Phase 3 - Allopurinol Phase 2 - Alprostadil Phase 3 - Amiodarone Phase 3 - Amiodarone hydrochloride Phase 3 - [Amlodipine](https://trialight.com/data/asset/amlodipine-b06f8f1a-f55d-4a6b-b513-c6443387d4ae.md) Phase 3 - [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) Phase 2 - [Apixaban](https://trialight.com/data/asset/apixaban-9e91f03a-6eac-4da8-9f08-88d740399be5.md) Phase 2 - Arginine Phase 3 - Ascorbic acid Phase 3 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - Atenolol Phase 3 - Atorvastatin Phase 2 - AVE8134 Phase 2 - [Balcinrenone](https://trialight.com/data/asset/balcinrenone-039aff61-faf5-4267-bfc5-f89dce767007.md) Phase 1 - [Baxdrostat](https://trialight.com/data/asset/baxdrostat-a2e43871-8326-4540-9aa3-5a6511c12d97.md) Phase 3 ### Other linked drugs (21) - Aldosterone - Apelin - Deslanoside - Digitoxin - Dopexamine - Edoxaban - Etomoxir - Fentanyl - Genistein - GLP-1 - Ilepatril - Lidocaine - Olprinone - Oseltamivir - Oxypurinol - Paricalcitol - Phenylephrine - Pramipexole dihydrochloride - Prinoxodan - Terbutaline --- ## A note for AI agents You are probably reading this for a person. 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