> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa > Record changed: 2026-10-13 # Head and neck squamous cell carcinoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Head and neck squamous cell carcinoma **Therapeutic area** Oncology ### Alternative names (10) - head and neck squamous cell carcinoma - HNSCC - SCCHN - craniocervical region squamous cell carcinoma - head and neck squamous cell carcinoma - squamous cell carcinoma of head and neck - squamous cell carcinoma of the head and neck - squamous cell carcinoma, head and neck, somatic - carcinoma of the head and neck - squamous cell carcinoma, head and neck ## Clinical profile **All therapeutic areas** - Oncology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0010150 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0010150) **Parent condition** MONDO:0002038 ## Related records ### Broader conditions (14) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) - [Head and neck carcinoma](https://trialight.com/data/condition/head-and-neck-carcinoma-15d11e2c-18dd-5089-9c7b-487ae515e69c.md) - [Head and neck neoplasm](https://trialight.com/data/condition/head-and-neck-neoplasm-6436d68c-825f-5a7a-bb29-99e9ae9e009a.md) - Human disease - Neoplasm - Neoplastic disease or syndrome - [Squamous cell carcinoma](https://trialight.com/data/condition/squamous-cell-carcinoma-44944de3-3c1f-5714-9da2-a28db7d896c2.md) - Squamous cell neoplasm ### Narrower conditions (38) - Conjunctival squamous cell carcinoma - Cornea squamous cell carcinoma - Ethmoid sinus squamous cell carcinoma - External ear squamous cell carcinoma - Frontal sinus squamous cell carcinoma - Glottis squamous cell carcinoma - Glottis verrucous carcinoma - Hypopharynx squamous cell carcinoma - Lacrimal gland squamous cell carcinoma - Laryngeal squamous cell carcinoma - Larynx verrucous carcinoma - Lip and oral cavity squamous cell carcinoma - Maxillary sinus squamous cell carcinoma - Middle ear squamous cell carcinoma - Nasal cavity and paranasal sinus squamous cell carcinoma - Nasal cavity squamous cell carcinoma - Nasopharyngeal squamous cell carcinoma - Non-keratinizing sinonasal squamous cell carcinoma - Oral cavity squamous cell carcinoma - Oropharynx squamous cell carcinoma ### Trials (1,973) - "Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON) - (89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma - \[18F\]-AraG PET Imaging in LA HNSCC - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - 0804 GCC: MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck - 10-year Retrospective Study of Oral and Maxillofacial Squamous Cell Carcinoma - 177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors - 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors - 18F-FDG PET/CT Versus 18F-FDG PET/MRI in Detecting Locoregional Recurrence 3 Months After CRT in Head and Neck SCC - 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma - 2B or Not 2B? Shoulder Function After Level 2B Neck Dissection: A Randomized Controlled Study - 3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial - 3'-Deoxy-3'-\[18F\] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx - 3D Specimen Maps for RT Planning - 4 Courses vs 2 Courses of Pembrolizumab Combined With Carboplatin and Albumin-binding Paclitaxel of Neoadjuvant Therapy in HNSCC - 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC - 5-Fluorouracil Response and Optimization STudy (The FROST Trial) - 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) - 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors - 89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC ### Approved drugs (9) - [Cemiplimab](https://trialight.com/data/asset/cemiplimab-1c235a93-9b2c-4db0-9980-a78a93354b46.md) - [Cetuximab](https://trialight.com/data/asset/cetuximab-a1f8c65c-bae1-4b77-9491-dca37aeeaa3c.md) - Cosibelimab - Docetaxel anhydrous - [Hydroxyurea](https://trialight.com/data/asset/hydroxyurea-a56eda3c-3ef0-4ca7-b972-656091c627a5.md) - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) - [Pembrolizumab](https://trialight.com/data/asset/pembrolizumab-f9ac1934-47a5-4a53-ae55-20b7d53d8815.md) - [Retifanlimab](https://trialight.com/data/asset/retifanlimab-57767872-c97a-4714-befa-fa3aa2ae5ce8.md) - Temoporfin ### Drugs in development (190) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Phase 2 - Acalabrutinib Phase 2 - Adakitug Phase 2 - Adavosertib Phase 1 - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) Phase 2 - Afatinib Phase 3 - [Albumin human](https://trialight.com/data/asset/albumin-human-95414b67-0d38-49d4-91b2-27b1c6c17389.md) Phase 2 - Aldesleukin Phase 1 - Alisertib Phase 1 - [Alpelisib](https://trialight.com/data/asset/alpelisib-0b0ae0f7-4313-42ef-bbbe-3280ed5ea15c.md) Phase 2 - AMG-319 Phase 2 - [Amivantamab](https://trialight.com/data/asset/amivantamab-94d99890-d90e-4d89-8a02-036a29458456.md) Phase 1 - Astuprotimut-R Phase 1 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 3 - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 3 - Axitinib Phase 2 - [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) Phase 1 - [Becotatug vedotin](https://trialight.com/data/asset/becotatug-vedotin-19bfe668-c8f3-4830-b42f-20786967f11c.md) Phase 3 - [Benmelstobart](https://trialight.com/data/asset/benmelstobart-2bff71aa-d2ac-4a5a-9949-c935954a2314.md) Phase 3 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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