> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/hairy-cell-leukemia-f53c6c12-084e-500e-b5b6-35769701ecdb > Record changed: 2026-11-04 # Hairy cell leukemia Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** Hairy cell leukemia (HCL) is a rare type of leukemia in which abnormal B-lymphocytes are present in the bone marrow, spleen and peripheral blood. It is a slowly progressive chronic lymphocytic leukemia (CLL). The name comes from the abnormally shaped lymphocytes with hair-like projections. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Hairy cell leukemia **Therapeutic area** Hematology ### Alternative names (9) - hairy cell leukemia - Hairy Cell Leukemia (HCL) - Hairy-cell Leukemia - HCL - HCL-C - leukemic reticuloendotheliosis - Progressive Hairy Cell Leukemia, Initial Treatment - Recurrent Hairy Cell Leukemia - classic hairy cell leukaemia ## Clinical profile **Severity** Severe ### All therapeutic areas (3) - Hematology - Immunology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018935) ## Identifiers **MONDO ID** MONDO:0018935 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018935) **Parent condition** MONDO:0004948 ## Related records ### Broader conditions (29) - Acute disease - Acute leukemia - [Acute lymphoblastic leukemia](https://trialight.com/data/condition/acute-lymphoblastic-leukemia-a7f89294-3477-5920-8fe1-8aa51fcd1d63.md) - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) - [B-cell neoplasm](https://trialight.com/data/condition/b-cell-neoplasm-ffd0710d-7dbd-55bc-a4a5-3c1cf532bac2.md) - [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) - Cancer or benign tumor - Chronic leukemia - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Indolent B-cell non-Hodgkin lymphoma - [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) - Leukocyte disorder - Lymphoid hemopathy ### Narrower conditions (4) - Hairy cell leukemia variant - Intrapelvic lymph node leukemic reticuloendotheliosis - Refractory hairy cell leukemia - Splenic manifestation of hairy cell leukemia ### Trials (239) - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - A Phase I, Multicenter Dose Escalation Study in Patients With Hairy Cell Leukemia - A Phase II Efficacy Study of Roferon-A in Hairy Cell Leukemia - A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia - A Pilot Study of the Safety and Activity of Escalating Doses of ON 01910.Na in Patients With Relapsed Mantle Cell Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, and Related Lymphoid Malignancies - A Standardized Nursing Intervention Protocol for HCT Patients - A Structured Walking Program or Standard Therapy in Cancer Patients Undergoing a Donor Bone Marrow Transplant - A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies - A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL) - [A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma](https://trialight.com/data/trial/a-study-to-evaluate-adverse-events-and-change-in-disease-cd8b4ab6-d8b7-455b-9d6d-9cd4b6fc1fdc.md) - A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Escalating Doses of AGS67E Given as Monotherapy in Subjects With Refractory or Relapsed Lymphoid Malignancies - A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies - ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies - Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation - Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies - Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer - Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma ### Approved drugs (4) - Cladribine - Interferon alfa-2B - Moxetumomab pasudotox - Pentostatin ### Drugs in development (26) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 1 - [Bendamustine](https://trialight.com/data/asset/bendamustine-07f7a21f-820a-4423-a534-0d6d0380b382.md) Phase 2 - Binimetinib Phase 2 - BL22 Phase 2 - Brexucabtagene autoleucel Phase 2 - Busulfan Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 - Dabrafenib Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 1 - Diphenhydramine Phase 2 - Encorafenib Phase 2 - [Epinephrine](https://trialight.com/data/asset/epinephrine-bdf4cabf-fe3e-447b-8984-310f4baf125a.md) Phase 2 - [Famotidine](https://trialight.com/data/asset/famotidine-5721dbb9-1373-4622-a660-e27ebf480acc.md) Phase 1 - [Fludarabine](https://trialight.com/data/asset/fludarabine-e03241fb-ac4f-4851-ae4f-6e8dad4f1d28.md) Phase 2 - Interferon alfa-2A Phase 2 - LMB-2 Phase 2 - [Obinutuzumab](https://trialight.com/data/asset/obinutuzumab-1aa4994f-1407-4a89-93f0-0b3aa295ad6e.md) Phase 2 - [Peginterferon alfa-2A](https://trialight.com/data/asset/peginterferon-alfa-2a-30150acd-a3d1-4c13-9915-fc321ebfd6ba.md) Phase 2 - [Plixorafenib](https://trialight.com/data/asset/plixorafenib-2fa70ff1-9eee-4187-9de1-ed7740bd8dec.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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