> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/genital-herpes-07f6bf40-9937-5924-bf15-bb89bedc2b84 > Record changed: 2026-10-13 # Genital herpes Therapeutic area Infectious Disease Rare disease No ## Definition and classification **Definition** Herpes simplex infection of the genitals, most commonly caused by the herpes simplex-2 virus. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Genital herpes **Therapeutic area** Infectious Disease ### Alternative names (3) - genital herpes - herpes genitalia - herpes genitalis ## Clinical profile **Disease mechanisms** - Acquired **Severity** Moderate ### All therapeutic areas (2) - Infectious Disease - Reproductive Health ## Identifiers **MONDO ID** MONDO:0005770 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005770) **Parent condition** MONDO:0004609 ## Related records ### Broader conditions (14) - Disease - Disease arising from reactivation of latent virus - Disease by body system or component - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - [Herpes simplex infectious disease](https://trialight.com/data/condition/herpes-simplex-infectious-disease-e68e9e47-8d4d-542b-bba5-bb8aaa1ebd60.md) - [Herpesviridae infectious disease](https://trialight.com/data/condition/herpesviridae-infectious-disease-aebfcafe-83be-52c0-b83f-f857b2e24dba.md) - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Primary viral infectious disease - Reproductive system disorder - [Sexually transmitted disease](https://trialight.com/data/condition/sexually-transmitted-disease-83eea810-d6b8-5af4-b68b-1ffbd99e273d.md) - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) - Viral sexually transmitted disease ### Narrower conditions (2) - Genital herpes simplex type 1 infectious disorder - Genital herpes simplex type 2 infectious disorder ### Trials (69) - A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons - A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital Herpes Infections in HIV-Infected Patients - A Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 - A Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an mRNA Vaccine Against Herpes Simplex Virus Type 2 (HSV-2) Post-Vaccination - A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation - A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. - A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes - A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes - A Study of the Characteristics of Patients Diagnosed With Recurrent Symptomatic Genital Herpetic Disease - A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients - [A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes](https://trialight.com/data/trial/a-study-on-the-reactogenicity-safety-immune-response-and-88155bbb-4f7a-45d2-a8f2-42878e9347e9.md) - A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes - A Study to Assess the Safety, Pharmacokinetics, and Tolerability of ABI-1179 in Healthy Subjects and in Subjects Seropositive for HSV-2 With Recurrent Genital Herpes - A Study to Compare the Efficacy and Safety of Valacyclovir Hydrochloride ( 256U87 ) Versus Acyclovir in the Treatment of Recurrent Anogenital Herpes Infections in HIV Infected Patients - A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding - A Study to Investigate the Efficacy, Safety and Tolerability of PEG in Patients With Genital Herpes - A Study With ASP2151 in Subjects With Recurrent Episodes of Genital Herpes - Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda - An Epidemiological Study to Assess Performance of Using Healthcare Tools to Understand Genital Herpes Simplex Virus-2 (HSV-2) in Patients ≥ 18 Years of Age in the United States and Europe. - Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212) ### Approved drugs (5) - [Acyclovir](https://trialight.com/data/asset/acyclovir-69352556-3ccf-40be-9470-76b950dab32b.md) - Acyclovir sodium - Famciclovir - Valacyclovir - Valacyclovir hydrochloride ### Drugs in development (5) - Amenamevir Phase 2 - Astodrimer Phase 1 - Astodrimer sodium Phase 1 - Pritelivir Phase 2 - [Sodium chloride](https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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