> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/gastroesophageal-reflux-disease-98b37c15-1154-58ee-9085-aa95708c220a > Record changed: 2026-11-04 # Gastroesophageal reflux disease Therapeutic area Gastroenterology Rare disease No ## Definition and classification **Definition** A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. **Genetic basis** Yes **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Gastroesophageal reflux disease **Therapeutic area** Gastroenterology ### Alternative names (19) - gastroesophageal reflux disease - acid reflux - Gastro-esophageal Reflux Disease (GERD) - gastroesophageal reflux - Gastroesophageal Reflux (GER) - Gastroesophageal Reflux (GERD) - Gastroesophageal Reflux Disease (GERD) - Gastroesophageal Reflux Disease and Esophageal Motility Disorders - Gastroesophageal Reflux Disease and Position - Gastroesophageal Reflux Disease(GERD) - Gastroesophageal Reflux Disorder - GERD - GERD (Gastroesophageal Reflux Disease) - GERD, Acid Reflux, Treatment - Reflux, Gastroesophageal - Refractory Gastroesophageal Reflux Disease - Refractory GERD - gastroesophageal reflux, paediatric - ger ## Clinical profile **All therapeutic areas** - Gastroenterology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007186) **Severity** Mild ### Disease mechanisms (2) - Genetic - Hereditary Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007186) ## Identifiers **MONDO ID** MONDO:0007186 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007186) **Parent condition** MONDO:0003749 ## Related records ### Broader conditions (10) - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Esophageal disorder - [Hereditary disease](https://trialight.com/data/condition/hereditary-disease-df2f8f05-e0c9-5777-8e51-c3b6639743d3.md) - Human disease - Stomach disorder - Upper digestive tract disorder ### Narrower conditions (1) - Duodenogastric reflux ### Trials (1,222) - "The Voice of Reflux" - Backflow of Gastric Juice Leads to Irritation of the Vocal Folds: Are There Typical Differences in the Voice? - \[Impedance Measurement for Non-Erosive Reflux Disease - 14473 - D9126C00001 Proof of Principle Study - Effect of AZD2066 on Transient Lower Esophageal Sphincter Relaxations - 2019-06 TRISCEND Study - 48 Hours Esophagal pH-monitoring With and Without Gaviscon - 7 Year Follow up Analysis on the Speed of Progression of Tooth Wear Using 3D Subtraction - 9-Step Magnetic Bariatric Revisional Surgery - A Blinded Randomized Clinical Study of RefluxStop™ Compared With Nissen Fundoplication in the Treatment of GERD - A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes - A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion - A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes - A Comparative Study on the Efficacy and Safety of E3810 in Patients With Non-erosive Gastroesophageal Reflux Disease - A Comparison of Cosmos Rx Medication Adherence Platform vs. Pharmacy Fill Adherence Measures - A Cross-sectional Study on the Prevalence and Extraesophageal Symptoms of Gastroesophageal Reflux Disease(GERD) in Patients With Upper GI Symptoms, Visiting the Outpatient Departments of Peripheral Hospitals in Greece - A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis. - A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients - A Feasibility Study of Confocal Microendoscopy in the Evaluation of Gastrointestinal Neoplasia -Project 1 - A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma - A Minimally-Invasive Sponge on a String Device for Screening for Barrett's Esophagus - A Multi-center, Randomized, Double-blind, Parallel-group, Placebo Controlled Phase III Study to Evaluate the Efficacy and Safety of LXI-15028 in Non-erosive Reflux Disease in Chinese Patients for 4 Weeks ### Approved drugs (30) - Bismuth subcitrate potassium - Carbenoxolone - Carbenoxolone sodium - Cimetidine - Cimetidine hydrochloride - Cisapride - Cisapride monohydrate - Dexlansoprazole - Esomeprazole magnesium - Esomeprazole potassium - Esomeprazole sodium - Esomeprazole strontium - [Famotidine](https://trialight.com/data/asset/famotidine-5721dbb9-1373-4622-a660-e27ebf480acc.md) - Irsogladine maleate - Lansoprazole - Misoprostol - Nizatidine - [Omeprazole](https://trialight.com/data/asset/omeprazole-042440e1-a0fc-438d-a87b-7f2e8fa68dad.md) - Omeprazole sodium - Pantoprazole sodium ### Drugs in development (65) - Abeprazan Phase 3 - Acetoxolone - AD-214 Phase 1 - Alginic acid Phase 3 - Anaprazole Phase 3 - Arbaclofen placarbil Phase 2 - Atovaquone Phase 1 - AZD1386 Phase 2 - AZD2066 Phase 1 - AZD2516 Phase 2 - Azeloprazole sodium Phase 1 - Baclofen Phase 3 - [Budesonide](https://trialight.com/data/asset/budesonide-15e6ba7b-3021-46e9-b180-bf23025bbc67.md) Phase 2 - Buspirone Phase 1 - Calcium carbonate Phase 1 - [Charcoal, activated](https://trialight.com/data/asset/charcoal-activated-74974a11-0327-42be-ba92-123123e02c3a.md) Phase 2 - Colesevelam hydrochloride Phase 3 - Desipramine Phase 3 - Domperidone Phase 3 - Enprostil Phase 2 ### Other linked drugs (28) - Almagate - [Aluminum hydroxide](https://trialight.com/data/asset/aluminum-hydroxide-a0230a1f-a5e2-439f-baa2-2b988b59e46d.md) - Amitriptyline - [Amoxicillin](https://trialight.com/data/asset/amoxicillin-09050e6a-69b4-42d1-b3eb-79212edcf388.md) - Chlorpromazine - Citalopram - Clarithromycin - Deoxycholic acid - [Erythromycin](https://trialight.com/data/asset/erythromycin-aedb4bea-725f-47b5-99f5-9aee0c68a896.md) - Erythromycin gluceptate - Erythromycin stearate - Esmolol - Hyaluronic acid - Hydrotalcite - Hydrotalcite anhydrous - Imipramine pamoate - Lidocaine - Lidocaine hydrochloride - Magnesium - Magnesium hydroxide --- ## A note for AI agents You are probably reading this for a person. 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