> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/gastroesophageal-junction-adenocarcinoma-de7e280e-cbd1-5266-a5dd-dda00261a706 > Record changed: 2026-10-13 # Gastroesophageal junction adenocarcinoma Therapeutic area Gastroenterology Rare disease No ## Definition and classification **Definition** A carcinoma that arises from glandular epithelial cells of the esophagogastric junction. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Gastroesophageal junction adenocarcinoma **Therapeutic area** Gastroenterology ### Alternative names (12) - gastroesophageal junction adenocarcinoma - adenocarcinoma - GEJ - adenocarcinoma of cardioesophageal junction - adenocarcinoma of gastroesophageal junction - adenocarcinoma of the EG junction - adenocarcinoma of the GE junction - adenocarcinoma of the cardioesophageal junction - adenocarcinoma of the esophagogastric junction - adenocarcinoma of the gastroesophageal junction - esophagogastric junction adenocarcinoma - gastroesophageal junction adenocarcinoma - esophagogastric adenocarcinoma ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Gastroenterology - Oncology ## Identifiers **MONDO ID** MONDO:0003219 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0003219) **Parent condition** MONDO:0004970 ## Related records ### Broader conditions (16) - [Adenocarcinoma](https://trialight.com/data/condition/adenocarcinoma-b5c321d1-7c49-5bf9-abd0-dfa99dbd5f29.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Digestive system cancer - Digestive system carcinoma - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - [Digestive system neoplasm](https://trialight.com/data/condition/digestive-system-neoplasm-2ebb9146-1d78-515a-92a3-749515a27d44.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Glandular cell neoplasm - Human disease - Neoplasm - Neoplastic disease or syndrome ### Trials (375) - 64Cu DOTA-Trastuzumab PET/CT in Studying Patients With Gastric Cancer - A Clinical Study of Iparomlimab and Tuvonralimab Combined With SOX Following Heterogeneous Radiotherapy as First-line Treatment for Unresectable Locally Advanced or Metastatic HER2-negative Gastric or Gastroesophageal Junction Adenocarcinoma - A Clinical Trial of the Safety and Anti-Tumor Activity of AB-201 in Subjects With Advanced HER2+ Solid Tumors - A Multi-center, Two-arm, Phase 2 Clinical Study on the Perioperative Treatment of HER2-positive Resectable Esophagogastric Junctional Adenocarcinoma With Nabulimab Combined With FLOT and Trastuzumab VS FLOT Combined With Trastuzumab - A Multicenter Cancer Biospecimen Collection Study - A Multicenter Randomized Controlled Phase II Trial of Iparomlimab and Tuvonralimab (QL1706) Combined With SOX Chemotherapy Versus Chemotherapy Alone in the Treatment of Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma - [A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors](https://trialight.com/data/trial/a-phase-1-first-in-human-study-of-okn4395-and-pembrolizumab-d5f0ed43-9c3d-4e12-976c-c1165c2cdf30.md) - [A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4](https://trialight.com/data/trial/a-phase-1-1b-of-rndo-564-single-agent-or-in-combination-with-98af17b9-b62c-4dde-b9ce-185a27ebb012.md) - A Phase 1b/2 Clinical Trial Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AUR103 Calcium in Patients With HER2-positive Advanced Gastric/Gastroesophageal Junction Adenocarcinoma - A Phase 2 Study of Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Junction (GEJ) Cancer - A Phase I/II Study of Oblimersen Plus Cisplatin and Fluorouracil in Gastric & Esophageal Junction Cancer - A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma - [A Phase II Clinical Study Evaluating SSGJ-706 in Combination Therapy for Advanced Gastrointestinal Cancers](https://trialight.com/data/trial/a-phase-ii-clinical-study-evaluating-ssgj-706-in-combination-eae307c2-aefc-486d-8283-3999a11b89fd.md) - A Phase III Clinical Study of Cadonilimab Plus SOX as Perioperative Treatment for Patients With Resectable G/GEJ Adenocarcinoma - A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer - A Prospective Clinical Study of Transthoracic Single-hole Assisted Laparoscopic Radical Gastrectomy for Siewert Ⅱ AEG - A Prospective Study of Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy for Siewert II ，III of Locally Advanced HER-2 Negative Adenocarcinoma at Gastroesophageal Junction - A Safety Study of SGN-2FF for Patients With Advanced Solid Tumors - A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection - A Study Comparing BL-M05D1 With the Investigator's Choice of Treatment Regimen in Patients With Claudin (CLDN)18.2-Positive Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma (GC/GEJC) Who Have Received Prior First-Line Treatment ### Approved drugs (4) - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) - [Fluorouracil](https://trialight.com/data/asset/fluorouracil-f8444d73-5c73-4f35-aa71-67d578277450.md) - [Tislelizumab](https://trialight.com/data/asset/tislelizumab-70601caf-7705-4f05-b211-e6a4d4556fe3.md) - [Zolbetuximab](https://trialight.com/data/asset/zolbetuximab-93fd9fa2-039b-41eb-a488-43bca0e39a5b.md) ### Drugs in development (51) - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) Phase 2 - [Albumin human](https://trialight.com/data/asset/albumin-human-95414b67-0d38-49d4-91b2-27b1c6c17389.md) Phase 2 - AMG-337 Phase 1 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 1 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Cadonilimab](https://trialight.com/data/asset/cadonilimab-3970701f-ffc8-4027-a97b-4e6c913803e6.md) Phase 3 - Camrelizumab Phase 2 - Cantuzumab ravtansine Phase 2 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 3 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 3 - Cobimetinib Phase 1 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - [Envafolimab](https://trialight.com/data/asset/envafolimab-067ce798-3523-4c36-9d89-3452238113d3.md) Phase 2 - Epirubicin Phase 2 - Fexagratinib Phase 2 - Fludarabine Phase 1 - [Fruquintinib](https://trialight.com/data/asset/fruquintinib-e15c1522-cabe-4f7b-a918-3ca55e1ef88a.md) Phase 1 - Ganetespib Phase 1 - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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