> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/estrogen-receptor-positive-breast-cancer-3bdba21b-1ba5-534a-9e7a-1d3f4d76885f > Record changed: 2026-11-04 # Estrogen-receptor positive breast cancer Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A subtype of breast cancer that is estrogen-receptor positive **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Estrogen-receptor positive breast cancer **Therapeutic area** Oncology ### Alternative names (7) - estrogen-receptor positive breast cancer - ER+ breast cancer - estrogen receptor positive breast cancer - Estrogen Receptor-Positive Breast Cancer - Estrogen-receptor-positive Breast Cancer - Oestrogen Receptor Positive Advanced Breast Cancer - oestrogen receptor positive breast cancer ## Clinical profile **All therapeutic areas** - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006512) **Severity** Severe ## Identifiers **MONDO ID** MONDO:0006512 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006512) **Parent condition** MONDO:0006116 ## Related records ### Broader conditions (17) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - [Breast carcinoma](https://trialight.com/data/condition/breast-carcinoma-e447567c-405f-500c-a7a4-766a76d59293.md) - Breast carcinoma by gene expression profile - [Breast disorder](https://trialight.com/data/condition/breast-disorder-c24c48eb-9ec6-54b1-80b7-1e9cec90eba4.md) - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Epithelial neoplasm - Human disease - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - [Neoplasm of thorax](https://trialight.com/data/condition/neoplasm-of-thorax-6bea3cc7-24fd-5ead-b244-15475a552098.md) - Neoplastic disease or syndrome - Thoracic cancer ### Narrower conditions (2) - Hormone receptor-positive breast cancer - Triple-positive breast carcinoma ### Trials (27) - (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer - A Randomised Trial Comparing Trastuzumab Deruxtecan to CDK4/6 Inhibitors in Non-luminal A, ER-positive/HER2-low Metastatic Breast Cancer - A Study Evaluating the Efficacy and Safety of De Trastuzumab (T-DXd) in Combination with Immunotherapy for the Neoadjuvant Treatment of HR-positive HER2 Low-expressing Chinese Patients with Early-stage Breast Cancer - A Study of Neoadjuvant SHR6390 in Combination With Anastrozole, Pyrotinib, and Trastuzumab in Patients With ER+/HER2+ Breast Cancer. - A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002) - [A Study to Learn How Well Participants With a Specific Type of Early Breast Cancer (ER-Positive, HER2-Negative) Tolerate and Stay on Treatment With Giredestrant and How They Feel During Treatment](https://trialight.com/data/trial/a-study-to-learn-how-well-participants-with-a-specific-type-18917ff1-7f98-4d8d-84c5-daf2d96c22ed.md) - Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer - An Observational Study to Assess Response to Tamoxifen in Breast Cancer Patients - Breast Re-irradiation After Second Ipsilateral Lumpectomy - Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i. - Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA) - Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancer - Electronic Medical Record-Based Nudge to Reduce SLNB - Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies - Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt) - Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer - Neoadjuvant Hormonal Therapy Combined With Chemoimmunotherapy - Neoadjuvant Treatment of Locally-advanced Breast Cancer Patients With Ribociclib and Letrozole - Onapristone and Fulvestrant for ER+ HER2- Metastatic Breast Cancer After Endocrine Therapy and CDK4/6 Inhibitors (The SMILE Study) - [Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer](https://trialight.com/data/trial/phase-1b-study-of-op-1250-palazestrant-in-combination-with-746c22ad-90a4-44fb-89ce-ea1783413128.md) ### Drugs in development (35) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Phase 1 - Afimoxifene Phase 2 - Alobresib Phase 1 - [Alpelisib](https://trialight.com/data/asset/alpelisib-0b0ae0f7-4313-42ef-bbbe-3280ed5ea15c.md) Phase 1 - Amcenestrant Phase 2 - [Anastrozole](https://trialight.com/data/asset/anastrozole-327e05a9-e5b7-41d1-a335-bd8a46453b55.md) Phase 2 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 2 - Crizotinib Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - Dalotuzumab Phase 2 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 3 - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) Phase 2 - [Elacestrant](https://trialight.com/data/asset/elacestrant-2250bfef-4063-4cd6-9907-defe7c123964.md) Phase 2 - Endoxifen Phase 2 - [Enzalutamide](https://trialight.com/data/asset/enzalutamide-d1214ac0-68e5-4752-9999-977e028ec483.md) Phase 2 - Estetrol Phase 1 - [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) Phase 1 - [Exemestane](https://trialight.com/data/asset/exemestane-367c47e6-e892-496e-bbb5-5b4926a3c31a.md) Phase 1 - [Fulvestrant](https://trialight.com/data/asset/fulvestrant-c32705f5-1d97-4fd5-a6ee-76fe1d8eba3a.md) Phase 2 - [Giredestrant](https://trialight.com/data/asset/giredestrant-c67ceef7-88fc-49f5-b635-5568fc80cd3c.md) Phase 2 ### Other linked drugs (1) - Imatinib --- ## A note for AI agents You are probably reading this for a person. 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