> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a > Record changed: 2026-10-13 # Esophageal squamous cell carcinoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC) that can affect any part of the esophagus, but is usually located in the upper or middle third. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Esophageal squamous cell carcinoma **Therapeutic area** Oncology ### Alternative names (18) - esophageal squamous cell carcinoma - ESCC - esophageal epidermoid carcinoma - esophageal scc - esophageal squamous cell cancer - esophageal squamous cell carcinoma - esophagus scc - esophagus squamous cell carcinoma - oesophagus scc - scc of esophagus - scc of the esophagus - scc of the oesophagus - squamous cell car. - esophagus - squamous cell car. - oesophagus - squamous cell carcinoma of esophagus - squamous cell carcinoma of oesophagus - squamous cell carcinoma of the esophagus - squamous cell carcinoma of the oesophagus ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Gastroenterology - Oncology ## Identifiers **MONDO ID** MONDO:0005580 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005580) **Parent condition** MONDO:0005096 ## Related records ### Broader conditions (21) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Carcinoma of esophagus - Digestive system cancer - Digestive system carcinoma - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - [Digestive system neoplasm](https://trialight.com/data/condition/digestive-system-neoplasm-2ebb9146-1d78-515a-92a3-749515a27d44.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) - Esophageal disorder - Human disease - Neoplasm - [Neoplasm of esophagus](https://trialight.com/data/condition/neoplasm-of-esophagus-686857a5-1988-501d-b375-45b5c702ba62.md) - Neoplastic disease or syndrome - [Squamous cell carcinoma](https://trialight.com/data/condition/squamous-cell-carcinoma-44944de3-3c1f-5714-9da2-a28db7d896c2.md) - Squamous cell neoplasm ### Narrower conditions (4) - Esophageal adenosquamous carcinoma - Esophageal basaloid carcinoma - Esophagus verrucous carcinoma - Undifferentiated carcinoma of esophagus ### Trials (666) - 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors - A Clinical Study of Chemoradiotherapy Sequential Fluzoparib in Pan-solid Tumors - A Clinical Study of SHR-9839 as Monotherapy or in Combination With Chemotherapy Plus Adebrelimab Versus Chemotherapy Plus Adebrelimab in Patients With Advanced Esophageal Squamous Cell Carcinoma - A Clinical Study of Sintilimab as Adjuvant Therapy in Node-positive ESCC - A Clinical Study on the Efficacy and Safety of Paclitaxel Polymeric Micelles and Cisplatin Combined With Cadonilimab as a Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma - A Clinical Trial Comparing HLX10 With Placebo Combined With Chemotherapy (Cisplatin + 5-fu) in the First-line Treatment of Locally Advanced/Metastatic Esophageal Squamous Cell Carcinoma (ESCC) - A Clinical Trial of Esophagectomy for Esophageal Carcinoma - A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) - A Comparison of Paclitaxel-based Three Regimens Concurrent With Radiotherapy for Patients With Local Advanced Esophageal Cancer - A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors - A Feasibility Trial of Nivolumab With Neoadjuvant CF or DCF Therapy for Locally Advanced Esophageal Carcinoma - A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors - A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors - A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors - A Multicenter Cancer Biospecimen Collection Study - A Multicenter Trial of YSQTG vs. Simulated Agents With Neoadjuvant Chemoradiotherapy or Chemoimmunotherapy for EC - A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer - A Perioperative Sintilimab and Chemotherapy in Esophageal Squamous Cell Carcinoma - A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors - [A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4](https://trialight.com/data/trial/a-phase-1-1b-of-rndo-564-single-agent-or-in-combination-with-98af17b9-b62c-4dde-b9ce-185a27ebb012.md) ### Approved drugs (1) - [Tislelizumab](https://trialight.com/data/asset/tislelizumab-70601caf-7705-4f05-b211-e6a4d4556fe3.md) ### Drugs in development (78) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 1 - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) Phase 2 - Afatinib Phase 2 - [Albumin human](https://trialight.com/data/asset/albumin-human-95414b67-0d38-49d4-91b2-27b1c6c17389.md) Phase 2 - [Alpelisib](https://trialight.com/data/asset/alpelisib-0b0ae0f7-4313-42ef-bbbe-3280ed5ea15c.md) Phase 1 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 3 - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 2 - [Benmelstobart](https://trialight.com/data/asset/benmelstobart-2bff71aa-d2ac-4a5a-9949-c935954a2314.md) Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Cadonilimab](https://trialight.com/data/asset/cadonilimab-3970701f-ffc8-4027-a97b-4e6c913803e6.md) Phase 2 - Camrelizumab Phase 3 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 3 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 3 - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Phase 2 - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) Phase 2 - [Cetuximab](https://trialight.com/data/asset/cetuximab-a1f8c65c-bae1-4b77-9491-dca37aeeaa3c.md) Phase 3 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 3 - [Dalpiciclib](https://trialight.com/data/asset/dalpiciclib-2001da9e-4c75-4a18-ae80-97f8c567dba5.md) Phase 2 - Decitabine Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 1 ### Other linked drugs (1) - Trilaciclib --- ## A note for AI agents You are probably reading this for a person. 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