> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/ectopic-acth-secretion-syndrome-fe7c0556-4ec1-5a98-ab4c-a1c89e4d2ec1
> Record changed: 2026-10-13

# Ectopic ACTH secretion syndrome

Therapeutic area

Endocrinology

Rare disease

No

## Definition and classification

**Definition**

A syndrome characterized by abnormal secretion of adrenocorticotrophic hormone in conjunction with neoplastic growth occurring anywhere in the body. The most common associations are tumors of the bronchus (oat cell or carcinoid), thymic tumors (epithelial or carcinoid), and pancreatic endocrine tumor. (DeVita et al. Cancer, p 1364\. 4th edition. Lippincott)

**Genetic basis**

No

**Non-human condition**

No

**Rare disease**

No

**Listing at source**

Listed

**Condition name**

Ectopic ACTH secretion syndrome

**Therapeutic area**

Endocrinology

### Alternative names (10)

- ectopic ACTH secretion syndrome
- ectopic ACTH secretion
- ectopic ACTH secretion syndrome
- ectopic ACTH syndrome
- hypercortisolism due to nonpituitary tumor
- hypercortisolism due to nonpituitary tumour
- ACTH syndromes, ectopic
- ectopic ACTH syndromes
- syndrome, ectopic ACTH
- syndromes, ectopic ACTH

## Clinical profile

**Disease mechanisms**

- Syndromic

**All therapeutic areas**

- Endocrinology

**Severity**

Severe

## Identifiers

**MONDO ID**

MONDO:0043472

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0043472)

**Parent condition**

MONDO:0005495

## Related records

### Broader conditions (10)

- Adrenal gland disorder
- Cancer or benign tumor
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md)
- Human disease
- Neoplastic disease or syndrome
- Neoplastic syndrome
- Syndromic disease

### Trials (43)

- A Prospective Cohort Study for Patients With Adrenal Diseases
- A Randomized Clinical Trial About Use of 3D Laparoscopy Versus 2D Laparoscopy in Adrenal Surgery
- A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome
- A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
- A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
- A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia
- A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome
- An Exploratory Investigation of a Supplement to Promote Cognitive Health Benefits
- An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome
- Cerebrovascular Disease: Quality of Life (CODE: QoL)
- China Adrenal Disease Registry
- Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
- Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome
- CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis
- Effect of Maternal Odor and Kangaroo Care on Serum Cortisol and Comfort Levels in Preterm Infants: a Randomised Trial
- Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá
- EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders
- Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome
- First-in-human Evaluation of \[18F\]CETO
- Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

### Drugs in development (1)

- Pasireotide Phase 2

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