> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/discoid-lupus-erythematosus-c6a42afd-1f66-51a5-994a-08529b48e2b5 > Record changed: 2026-10-13 # Discoid lupus erythematosus Therapeutic area Immunology Rare disease Yes ## Definition and classification **Definition** A chronic, autoimmune skin condition that manifests with a red, scaling rash, most often found on the face, ears, and scalp; these lesions often lead to permanent scarring and dyspigmentation. Patients may have lesions with or without other symptoms or antibodies suggestive of systemic lupus erythematosus (SLE). **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Discoid lupus erythematosus **Therapeutic area** Immunology ### Alternative names (2) - discoid lupus erythematosus - DLE ## Clinical profile **Severity** Mild ### All therapeutic areas (2) - Immunology - Rheumatology ## Identifiers **MONDO ID** MONDO:0019558 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019558) **Parent condition** MONDO:0015574 ## Related records ### Broader conditions (10) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - Chronic cutaneous lupus erythematosus - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - [Cutaneous lupus erythematosus](https://trialight.com/data/condition/cutaneous-lupus-erythematosus-d8209c16-c236-521f-8fd1-cd89b5810e23.md) - Disease - Disease by body system or component - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Lupus erythematosus - [Rheumatic disorder](https://trialight.com/data/condition/rheumatic-disorder-e863530e-2c28-5a33-b1be-d12fa4d746b9.md) ### Trials (40) - A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - A Multicentre, Randomised, Double-blind, Positive-control Clinical Trial Evaluating Dihydroartemisinin Tablets for the Treatment of Discoid Lupus Erythematosus - A Non-drug Study Profiling Cutaneous Lupus - A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus - A Pilot Trial of Topical Thalidomide for the Management of Chronic Discoid Lupus Erythematosus - A Pooled Analysis of the HGS1006-C1056 (BLISS-52) and HGS1006-C1057 (BLISS-76) Studies - A Research Study to Assess if CC-930 is Safe in Treating Subjects With Discoid Lupus Erythematosus - A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease - A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2) - A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers - A Study to Assess the Safety and Efficacy of Secukinumab in Alleviating Symptoms of Discoid Lupus Erythematosus - A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Participants With Cutaneous Lupus Erythematosus (CLE) - A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) - A Study to Investigate the Safety, Tolerability, Drug Levels and Drug Effects of BMS-986326 in Adult Participants With Different Forms of Lupus - Autologous Polyclonal Tregs for Lupus - Comparing the Therapeutic Efficacy of Pimecrolimus Cream With Betamethasone Cream for Discoid Lupus Erythematosus - Cutaneous Lupus Erythematosus and Elidel - Discoid Lupus Erythematosus of the Scalp and a Trial of Biologic Therapy With Raptiva - Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions ### Drugs in development (10) - AMG-811 Phase 1 - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) Phase 1 - Daxdilimab Phase 2 - Delgocitinib Phase 2 - Niacinamide Early phase 1 - [Ruxolitinib](https://trialight.com/data/asset/ruxolitinib-3ab34d42-3776-4160-9bc2-d149204acfd5.md) Phase 2 - [Secukinumab](https://trialight.com/data/asset/secukinumab-6a7cb482-c244-4544-b6c6-4d8b9bb415bf.md) Phase 2 - Tanzisertib Phase 2 - Thalidomide Phase 2 - Tofacitinib citrate Early phase 1 --- ## A note for AI agents You are probably reading this for a person. 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