> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/digestive-system-neuroendocrine-neoplasm-4530c360-ae7d-5fe1-b058-35d238f22bb1 > Record changed: 2026-11-04 # Digestive system neuroendocrine neoplasm Therapeutic area Gastroenterology Rare disease Yes ## Definition and classification **Definition** A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas). **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Digestive system neuroendocrine neoplasm **Therapeutic area** Gastroenterology ### Alternative names (25) - digestive system neuroendocrine neoplasm - alimentary part of gastrointestinal system NET - alimentary part of gastrointestinal system neuroendocrine neoplasm - alimentary part of gastrointestinal system neuroendocrine tumor - alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade - alimentary part of gastrointestinal system neuroendocrine tumour - carcinoid tumor of digestive system - carcinoid tumour of digestive system - digestive system NET - digestive system neuroendocrine tumor - digestive system neuroendocrine tumor, well differentiated, low or intermediate grade - digestive system neuroendocrine tumour - gastro-enteropancreatic neuroendocrine tumor - gastro-enteropancreatic neuroendocrine tumour - gastroenteropancreatic endocrine tumor - gastroenteropancreatic endocrine tumour - gastroenteropancreatic neuroendocrine neoplasm - gastrointestinal neuroendocrine neoplasm - gastrointestinal system neuroendocrine neoplasm - neuroendocrine neoplasm of alimentary part of gastrointestinal system - neuroendocrine neoplasm of digestive system - carcinoid tumor - carcinoid tumour - GEP tumors - GEP tumours ## Clinical profile **Severity** Moderate ### All therapeutic areas (3) - Endocrinology - Gastroenterology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024503) ## Identifiers **MONDO ID** MONDO:0024503 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024503) **Parent condition** MONDO:0004335 ## Related records ### Broader conditions (12) - Cancer or benign tumor - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - [Digestive system neoplasm](https://trialight.com/data/condition/digestive-system-neoplasm-2ebb9146-1d78-515a-92a3-749515a27d44.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Endocrine gland neoplasm - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - Human disease - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplastic disease or syndrome - [Neuroendocrine neoplasm](https://trialight.com/data/condition/neuroendocrine-neoplasm-ab85715e-e4fa-5698-91d9-024cf0bab33c.md) ### Narrower conditions (79) - Ampulla of vater small cell neuroendocrine carcinoma - Anal canal neuroendocrine neoplasm - Appendix L-cell glucagon-like peptide-producing neuroendocrine tumor - Appendix neuroendocrine neoplasm - Appendix neuroendocrine tumor G1 - Ascending colon neuroendocrine tumor G1 - Cecum neuroendocrine tumor G1 - Classic neuroendocrine tumor of appendix - Colon neuroendocrine neoplasm - Colon neuroendocrine tumor G1 - Colon small cell neuroendocrine carcinoma - Colonic L-cell glucagon-like peptide producing tumor - Colorectal neuroendocrine tumor G1 - Digestive system neuroendocrine tumor, grade 1/2 - Duodenal gastrin-producing neuroendocrine tumor - Duodenal neuroendocrine neoplasm - Duodenal neuroendocrine tumor, well differentiated, low or intermediate grade - Duodenal somatostatinoma - Enterochromaffin cell serotonin-producing pancreatic neuroendocrine tumor - Esophageal neuroendocrine tumor ### Trials (87) - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - 177Lu-DOTATOC for the Treatment of Patients With Somatostatin Receptor Positive NETs - 177Lutetium-octreotate Treatment Prediction Using Multimodality Imaging in Refractory NETs - 211At-MABG in Adults With Advanced Neuroendocrine Cancers - 68Ga-DOTATOC PET for the Evaluation of Gastroenteropancreatic Neuroendocrine Tumours - 68Ga-DOTATOC Radio-Guided Surgery With β-Probe in GEP-NET - 68Ga-OPS202 Study for Diagnostic Imaging of GEP NET - 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) - A Biological Study of Resveratrol's Effects on Notch-1 Signaling in Subjects With Low Grade Gastrointestinal Tumors - A Clinical Trial Evaluating the Safety of Combining Lutathera(R) and Azedra(R) to Treat Mid-gut Neuroendocrine Tumors - A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors - A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC) - A Study of Famitinib in Patients With Advanced or Metastatic Gastroenteropancreatic Neuroendocrine Tumor - A Study of Peptide Receptor Radionuclide Therapy (PRRT) Use in Neuroendocrine Tumor (NET) Patients in Germany - A Study of Treatment Patterns and Outcomes in Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) Patients - A Study to Assess the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Debio 4126 in Participants With Acromegaly or Functioning Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) - A Study to Understand Participant's Experiences in Gastro-enteropancreatic Neuroendocrine Tumors (GEP-NETs) and Acromegaly - A Trial Evaluating the Activity and Safety of Combination Between Cabozantinib and Temozolomide in Lung and GEP-NENS Progressive After Everolimus, Sunitinib or PRRT (CABOTEM) - A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET - Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors ### Approved drugs (1) - Interferon alfa-2B ### Drugs in development (29) - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Phase 2 - Copper oxodotreotide CU-64 Phase 2 - Edotreotide Phase 3 - Edotreotide gallium GA-68 Phase 1 - [Etoposide](https://trialight.com/data/asset/etoposide-796d2f5b-cce5-4ec5-8a1f-c80f2bfbc7aa.md) Phase 2 - [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) Phase 3 - Famitinib Phase 2 - [Filgrastim](https://trialight.com/data/asset/filgrastim-942bf0d3-0bf1-4bf8-9e38-81a6c277d728.md) Phase 2 - Fludeoxyglucose F 18 Phase 2 - [Fluorouracil](https://trialight.com/data/asset/fluorouracil-f8444d73-5c73-4f35-aa71-67d578277450.md) Phase 2 - [Ipilimumab](https://trialight.com/data/asset/ipilimumab-06c42b29-e333-4f3c-94fe-dbea5fe48cd4.md) Phase 2 - [Irinotecan](https://trialight.com/data/asset/irinotecan-a601fe30-4b46-4a3b-bf58-6c490646db73.md) Phase 1 - [Irinotecan hydrochloride](https://trialight.com/data/asset/irinotecan-hydrochloride-c1f6b7df-7c76-40f1-92fe-12d71b1f3b25.md) Phase 2 - Lanreotide Phase 3 - [Leucovorin calcium](https://trialight.com/data/asset/leucovorin-calcium-8da292ca-1b92-4365-b525-77d897b1c096.md) Phase 2 - Lurbinectedin Phase 1 - Lutetium oxodotreotide LU-177 Phase 3 - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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