> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/diffuse-scleroderma-1fb050b5-6049-5a37-bdc9-86f3ec6ce2c5 > Record changed: 2026-11-04 # Diffuse scleroderma Therapeutic area Dermatology Rare disease No ## Definition and classification **Definition** A variant of systemic scleroderma characterized by sclerosis of the skin, Raynaud phenomenon, and organ involvement, including pulmonary fibrosis, renal disease, and gastrointestinal tract involvement. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Diffuse scleroderma **Alternative names** - diffuse scleroderma **Therapeutic area** Dermatology ## Clinical profile **Severity** Severe ### All therapeutic areas (3) - Dermatology - Immunology - Rheumatology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005019) ## Identifiers **MONDO ID** MONDO:0005019 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005019) **Parent condition** MONDO:0005100 ## Related records ### Broader conditions (11) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Disease - Disease by body system or component - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Integumentary system disorder - [Rheumatic disorder](https://trialight.com/data/condition/rheumatic-disorder-e863530e-2c28-5a33-b1be-d12fa4d746b9.md) - Scleroderma - [Skin disorder](https://trialight.com/data/condition/skin-disorder-c8e27943-0efd-5c2b-abce-01c2ef37e853.md) - [Systemic sclerosis](https://trialight.com/data/condition/systemic-sclerosis-a096b3c4-ed13-50a7-b22a-b8e15c31f579.md) ### Trials (308) - 6-minute Pegboard Ring Test in Patients With Scleroderma - A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease - A Clinical Study on Systemic Sclerosis and the Validation of French-language Questionnaires Assessing Disability, Quality of Life, and Disease Status. - A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis - A Clinical Trial for CTD-ILD Treatment - A Double-Blinded Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986020 Versus Placebo in Diffuse Cutaneous Systemic Sclerosis (dcSSc) - [A Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients With Diffuse Cutaneous Systemic Sclerosis](https://trialight.com/data/trial/a-multicenter-trial-to-evaluate-the-efficacy-safety-1140ef0a-f792-4396-92eb-e445512ceaa2.md) - A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma - A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases - A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2) - A Phase 1/2 Study of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis. - A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma - A Rho-kinase Inhibitor (Fasudil) in the Treatment of Raynaud's Phenomenon - A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease - A Safety and Efficacy Study of FCR001 in Adults With Rapidly Progressive Diffuse Cutaneous Systemic Sclerosis - A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon - A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases - A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma - A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases - A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea) ### Drugs in development (32) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 2 - Acetylcysteine Phase 2 - Asengeprast Phase 2 - AVID-200 Phase 1 - [Belimumab](https://trialight.com/data/asset/belimumab-a26501e5-b55d-4ccb-a721-a60267831e12.md) Phase 2 - Belumosudil Phase 2 - Brentuximab vedotin Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - Dersimelagon Phase 2 - Etrinabdione Phase 2 - [Fipaxalparant](https://trialight.com/data/asset/fipaxalparant-54ba7730-fde2-46ea-850d-51fdd6913478.md) Phase 2 - [Fludarabine](https://trialight.com/data/asset/fludarabine-e03241fb-ac4f-4851-ae4f-6e8dad4f1d28.md) Phase 1 - Fresolimumab Phase 1 - Human immunoglobulin G Phase 2 - Ianalumab Phase 2 - Ifetroban Phase 2 - Lanifibranor Phase 2 - Lenabasum Phase 3 - Methoxsalen Phase 2 - Mycophenolate mofetil Phase 2 ### Other linked drugs (3) - Ambrisentan - Iguratimod - [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md) --- ## A note for AI agents You are probably reading this for a person. 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