> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/diastolic-heart-failure-b3fbecba-f0d5-5a66-ac3b-8843d29791ea > Record changed: 2026-10-13 # Diastolic heart failure Therapeutic area Cardiology Rare disease No ## Definition and classification **Definition** Heart failure caused by abnormal myocardial relaxation during diastole leading to defective cardiac filling. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Diastolic heart failure **Alternative names** - diastolic heart failure **Therapeutic area** Cardiology ## Clinical profile **All therapeutic areas** - Cardiology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0006727 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006727) **Parent condition** MONDO:0005009 ## Related records ### Broader conditions (7) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Congestive heart failure - Disease - Disease by body system or component - Heart disorder - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) - Human disease ### Trials (257) - 2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV). - A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers - A Preliminary Study for INFORMED - A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction - A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure - A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction \[ULTIMATE-HFpEF\] - A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) - A Study of a Technology-enabled Disease Management Program to Reduce Hospitalizations for Heart Failure - A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity - A Study of LY3971297 in Participants With Heart Failure - A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure - A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial - A Study to Assess the Effect AZD4831 in Japanese and Chinese Healthy Volunteers - A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF - AB-1002 in Patients With Class III Heart Failure - AI-based Echocardiographic Quantification in Heart Failure - AI-based Echocardiography for Detection of Cardiac Amyloidosis - AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices - Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function - Aliskiren and Renin Inhibition in Diastolic Heart Failure ### Drugs in development (14) - Alagebrium Phase 2 - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) Phase 2 - Ivabradine Phase 2 - Metoprolol Phase 2 - Perhexiline Phase 2 - [Potassium chloride](https://trialight.com/data/asset/potassium-chloride-e069c577-a260-48f9-bde9-bdc7a3fbbad5.md) Phase 2 - Potassium nitrate Phase 2 - Ranolazine Phase 2 - Ribose (pyranose) Phase 2 - Sildenafil Phase 3 - Sitaxentan sodium Phase 2 - [Spironolactone](https://trialight.com/data/asset/spironolactone-93f75de1-5c35-41da-89b4-bb7fd4b3da51.md) Phase 3 - Ubidecarenone Phase 2 - Udenafil Phase 3 ### Other linked drugs (4) - Aliskiren - Atorvastatin - Eplerenone - Lisinopril --- ## A note for AI agents You are probably reading this for a person. 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