> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9 > Record changed: 2026-10-13 # Diabetic kidney disease Therapeutic area Metabolic Disease Rare disease No ## Definition and classification **Definition** Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Diabetic kidney disease **Therapeutic area** Metabolic Disease ### Alternative names (5) - diabetic kidney disease - DKD - diabetic nephropathy - type 1 diabetes nephropathy - type 2 diabetes nephropathy ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Metabolic Disease - Nephrology ## Identifiers **MONDO ID** MONDO:0005016 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005016) **Parent condition** MONDO:0005066 ## Related records ### Broader conditions (8) - [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) - Metabolic disease - [Urinary system disorder](https://trialight.com/data/condition/urinary-system-disorder-68e8d758-aac9-544b-8378-87fe59b2c7b0.md) ### Trials (342) - "Dapagliflozin vs Dapagliflozin-Finerenone for Albuminuria in CKD With Type 2 Diabetes" - "Residual Kidney Function and Oxidative Stress in Incremental vs Standard Peritoneal Dialysis (2 Mexican Centers)" - 6-Month Safety And Efficacy Study Of TTP488 In Patients With Type 2 Diabetes And Persistent Albuminuria - A Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol in Combination on Patients With Diabetic Nephropathy - A Cohort Study on the Efficacy of Bariatric Surgery for Rapidly Progressing Diabetic Nephropathy - A Double-blind Study to Investigate Efficacy, Safety and Tolerability of BAY1142524 in Patients With Type II Diabetes and a Clinical Diagnosis of Diabetic Kidney Disease - A Long-Term Follow-Up Study of Participants Exposed to REACT - A Phase 2 Multi-Center Study To Evaluate The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist In Adults With Type 2 Diabetes And Overt Nephropathy - A Phase 2b Diabetic Kidney Disease Study - A Phase 3 Study of Bardoxolone Methyl in Patients With Diabetic Kidney Disease; AYAME Study - A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With Nephropathy - A Study in Participants With Diabetic Kidney Disease - A Study in Patients With Diabetes Mellitus Type II of the Effect on Albuminuria of 24 Week Treatment With Valsartan, Benazepril, and Valsartan+Benazepril - A Study of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors - A Study of Participants With Chronic Kidney Disease Previously Treated With REACT - A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Type 2 Diabetic Subjects With Microalbuminuria - A Study to Evaluate Pharmacodynamics, Safety, Tolerability and Pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects With Albuminuria - A Study to Evaluate Pharmacodynamics, Safety, Tolerability and Pharmacokinetics of MT-3995 in Type II Diabetic Nephropathy Subjects With Albuminuria and Moderately Decreased GFR - A Study to Evaluate the Effect of CCX140-B on Urinary Albumin Excretion in Subjects With Type 2 Diabetes and Albuminuria - A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney Disease ### Approved drugs (2) - Captopril - Irbesartan ### Drugs in development (80) - Aliskiren Phase 2 - Atrasentan Phase 3 - Avosentan Phase 3 - Azeliragon Phase 2 - Bardoxolone methyl Phase 3 - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) Phase 2 - Bindarit Phase 2 - BMS-813160 Phase 2 - Calcitriol Phase 3 - [Calcium carbonate](https://trialight.com/data/asset/calcium-carbonate-37e10d9b-34b0-4b9a-ad7f-b08adfd15b03.md) Phase 2 - Canagliflozin Phase 3 - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) Phase 2 - Corticotropin Phase 2 - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) Phase 2 - Defibrotide Phase 3 - Dimesna Phase 3 - Duloxetine Phase 2 - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) Phase 3 - Eplerenone Phase 2 - Fenofibrate Phase 2 ### Other linked drugs (14) - Allopurinol - Beraprost sodium - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) - Furosemide - Gemigliptin - Henagliflozin - Ilepatril - Losartan potassium - [Minocycline](https://trialight.com/data/asset/minocycline-0789feeb-1396-4fb9-bfd9-d51fefbb5e59.md) - Oxygen - Recombinant human kallikrein-1 - Rinvecalinase alfa - Solizmestrocel - Valziflocept --- ## A note for AI agents You are probably reading this for a person. 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