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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/desmoid-tumor-ba8c4931-d9d2-5438-88c9-5cc562a19815 > Record changed: 2026-10-13 # Desmoid tumor Therapeutic area Rheumatology Rare disease Yes ## Definition and classification **Definition** A desmoid tumor (DT) is a benign, locally invasive soft tissue tumor associated with a high recurrence rate but with no metastatic potential. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Desmoid tumor **Therapeutic area** Rheumatology ### Alternative names (13) - desmoid tumor - aggressive fibromatosis - deep fibromatosis - deep fibromatosis/desmoid tumor - deep fibromatosis/desmoid tumour - desmoid fibromatosis - desmoid tumor - desmoid type fibromatosis - desmoid-type fibromatosis - FIF - desmoid disorder, hereditary - desmoid/aggressive fibromatosis - familial infiltrative fibromatosis ## Clinical profile **Severity** Mild ### Disease mechanisms (2) - Genetic - Hereditary ### All therapeutic areas (2) - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0007608 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007608) **Parent condition** MONDO:0005031 ## Related records ### Broader conditions (17) - Cancer or benign tumor - Connective and soft tissue neoplasm - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Fibroblastic neoplasm - Fibromatosis - Hereditary disease - Hereditary disorder of connective tissue - Human disease - Mesenchymal cell neoplasm - Neoplasm - Neoplastic disease or syndrome - Soft tissue neoplasm ### Narrower conditions (1) - Desmoid tumor caused by somatic mutation ### Trials (68) - 18F-FES PET/CT in Imaging Patients With Desmoid Tumors - A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome - A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis - A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors - A Randomized, Double-blind,Phase Ⅲ Study of Liposome Doxorubicin in Desmoid Tumor - A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). - A Study in Adults With Desmoid Tumors - A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery - A Study of AL102 in Patients With Progressing Desmoid Tumors - A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC) - A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) - A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor - Arterial Chemoembolization for the Treatment of Desmoid Fibromatosis - Burden of Disease and Living Situation in Desmoid Patients - Clinical Study of Anlotinib Combined With Chemotherapy in the Treatment of Unresectable Advanced Desmoid Tumor - Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma - Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies - Cryoablation for Advanced and Refractory Desmoid Tumors - Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting - Cryotherapy in the Treatment of Desmoid Tumors ### Approved drugs (1) - Nirogacestat hydrobromide ### Drugs in development (16) - Aminolevulinic acid Phase 2 - Doxorubicin Phase 3 - [Hydroxyurea](https://trialight.com/data/asset/hydroxyurea-a56eda3c-3ef0-4ca7-b972-656091c627a5.md) Phase 2 - Imatinib Phase 2 - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Phase 2 - [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md) Phase 2 - [Nirogacestat](https://trialight.com/data/asset/nirogacestat-3fcb771a-72a0-450b-adde-a88a42aee6e0.md) Phase 3 - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 1 - [Sodium chloride](https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585.md) Phase 3 - Sorafenib tosylate Phase 3 - Sulindac Phase 2 - [Tamoxifen citrate](https://trialight.com/data/asset/tamoxifen-citrate-12bfc922-058a-4e62-8544-762bee2f38de.md) Phase 2 - Tegavivint Phase 1 - Toremifene Phase 2 - Vactosertib Phase 1 - Vinblastine sulfate Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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