Desmoid tumor
Therapeutic area
Rheumatology
Rare disease
Yes
- Definition
- A desmoid tumor (DT) is a benign, locally invasive soft tissue tumor associated with a high recurrence rate but with no metastatic potential.
- Genetic basis
- Yes
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Desmoid tumor
- Therapeutic area
- Rheumatology
- desmoid tumor
- aggressive fibromatosis
- deep fibromatosis
- deep fibromatosis/desmoid tumor
- deep fibromatosis/desmoid tumour
- desmoid fibromatosis
- desmoid tumor
- desmoid type fibromatosis
- desmoid-type fibromatosis
- FIF
- desmoid disorder, hereditary
- desmoid/aggressive fibromatosis
- familial infiltrative fibromatosis
- Severity
- Mild
- Genetic
- Hereditary
- Oncology
- Rheumatology
- MONDO ID
- MONDO:0007608
- Parent condition
- MONDO:0005031
Related records
Broader conditions (17)
- Cancer or benign tumor
- Connective and soft tissue neoplasm
- Connective tissue disorder
- Connective tissue neoplasm
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Fibroblastic neoplasm
- Fibromatosis
- Hereditary disease
- Hereditary disorder of connective tissue
- Human disease
- Mesenchymal cell neoplasm
- Neoplasm
- Neoplastic disease or syndrome
- Soft tissue neoplasm
Narrower conditions (1)
- Desmoid tumor caused by somatic mutation
Trials (68)
- 18F-FES PET/CT in Imaging Patients With Desmoid Tumors
- A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome
- A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis
- A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors
- A Randomized, Double-blind,Phase Ⅲ Study of Liposome Doxorubicin in Desmoid Tumor
- A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP).
- A Study in Adults With Desmoid Tumors
- A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery
- A Study of AL102 in Patients With Progressing Desmoid Tumors
- A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC)
- A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF)
- A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor
- Arterial Chemoembolization for the Treatment of Desmoid Fibromatosis
- Burden of Disease and Living Situation in Desmoid Patients
- Clinical Study of Anlotinib Combined With Chemotherapy in the Treatment of Unresectable Advanced Desmoid Tumor
- Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma
- Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies
- Cryoablation for Advanced and Refractory Desmoid Tumors
- Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting
- Cryotherapy in the Treatment of Desmoid Tumors
Approved drugs (1)
- Nirogacestat hydrobromide
Drugs in development (16)
- Aminolevulinic acid Phase 2
- Doxorubicin Phase 3
- Hydroxyurea Phase 2
- Imatinib Phase 2
- Imatinib mesylate Phase 2
- Methotrexate Phase 2
- Nirogacestat Phase 3
- Sirolimus Phase 1
- Sodium chloride Phase 3
- Sorafenib tosylate Phase 3
- Sulindac Phase 2
- Tamoxifen citrate Phase 2
- Tegavivint Phase 1
- Toremifene Phase 2
- Vactosertib Phase 1
- Vinblastine sulfate Phase 2