> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/dermatomyositis-363b640a-406f-523a-ae6a-6f4abe2008fb > Record changed: 2026-11-04 # Dermatomyositis Therapeutic area Rheumatology Rare disease Yes ## Definition and classification **Definition** Dermatomyositis (DM) is a type of idiopathic inflammatory myopathy characterized by evocative skin lesions and symmetrical proximal muscle weakness. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Dermatomyositis **Therapeutic area** Rheumatology ### Alternative names (6) - dermatomyositis - Dermatomyositis, Adult Type - dermatopolymyositis - DM - adult dermatomyositis - Amyopathic dermatomyositis ## Clinical profile **Disease mechanisms** - Inflammatory Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0016367) **Severity** Severe ### All therapeutic areas (3) - Dermatology - Neuromuscular Disease - Rheumatology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0016367) ## Identifiers **MONDO ID** MONDO:0016367 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0016367) **Parent condition** MONDO:0002406 ## Related records ### Broader conditions (21) - [Acquired idiopathic inflammatory myopathy](https://trialight.com/data/condition/acquired-idiopathic-inflammatory-myopathy-18d0eb22-6fbd-59d0-889d-3ac4266a57f2.md) - Acquired skeletal muscle disease - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Human disease - Idiopathic disease - Idiopathic inflammatory myopathy - Inflammatory disease - Integumentary system disorder - Muscle tissue disorder - [Musculoskeletal system disorder](https://trialight.com/data/condition/musculoskeletal-system-disorder-16f6e157-12a0-54ee-9e24-377731f344a5.md) - Myopathy - [Myositis disease](https://trialight.com/data/condition/myositis-disease-9eae0a90-6131-52a2-b0a4-c5271d6f2554.md) - [Polymyositis](https://trialight.com/data/condition/polymyositis-529cdfe4-6d04-5195-97d5-8828fd88463b.md) - [Rheumatic disorder](https://trialight.com/data/condition/rheumatic-disorder-e863530e-2c28-5a33-b1be-d12fa4d746b9.md) - Skeletal muscle disorder ### Narrower conditions (13) - Adermatopathic dermatomyositis - Adult dermatomyositis - Amyopathic dermatomyositis - Anti-MDA5 dermatomyositis - Anti-Mi2 dermatomyositis - Anti-NXP2 dermatomyositis - Anti-SAE dermatomyositis - Anti-TIF1 dermatomyositis - Classical dermatomyositis - Clinically amyopathic dermatomyositis - Hypomyopathic dermatomyositis - Juvenile dermatomyositis - Neonatal dermatomyositis ### Trials (181) - 3T Therapy in the Treatment of MDA5-positive Dermatomyositis - A 12-Week Open-Label Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Skin-Predominant Dermatomyositis - A Case-control Study to Assess Risk of Coronary Heart Disease in Idiopathic Inflammatory Myopathy - A Clinical Trial for CTD-ILD Treatment - A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101 - A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases - A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis - A Pilot Study of Etanercept in Dermatomyositis - A Study Evaluating the Effects of GLPG3667 Given as Oral Treatment for up to 24 Weeks in Adults With Dermatomyositis - A Study In Adults With Moderate To Severe Dermatomyositis - A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases - A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases - [A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases](https://trialight.com/data/trial/a-study-of-healthy-donor-cd19-targeted-allogeneic-car-t-b1d04a74-424e-4293-b03a-d260c48aba9d.md) - A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments - A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy - A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis - A Study to Evaluate Safety of Multi-Dose MEDI-545 in Adult Patients With Dermatomyositis or Polymyositis - A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM) - A Study to Evaluate the Safety and Efficacy of Apremilast in the Treatment of Skin Disease in Patients With Dermatomyositis - A Study to Evaluate VIB7734 in Participants With Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE), Sjogren's Syndrome, Systemic Sclerosis, Polymyositis, and Dermatomyositis ### Approved drugs (3) - Cortisone acetate - [Prednisolone](https://trialight.com/data/asset/prednisolone-783fce19-b285-4835-90c3-3db5a6364414.md) - [Prednisone](https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6.md) ### Drugs in development (44) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 3 - Aldesleukin Phase 3 - Anakinra Phase 2 - [Anifrolumab](https://trialight.com/data/asset/anifrolumab-4df440fe-efd0-44aa-828f-ea4381468125.md) Phase 3 - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) Phase 2 - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) Phase 3 - Bazlitoran Phase 2 - [Belimumab](https://trialight.com/data/asset/belimumab-a26501e5-b55d-4ccb-a721-a60267831e12.md) Phase 2 - Brepocitinib Phase 3 - Corticotropin Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 - Cyclosporine Phase 2 - Daxdilimab Phase 2 - Dazukibart Phase 2 - [Deucravacitinib](https://trialight.com/data/asset/deucravacitinib-3033fa9d-d652-4397-81c1-5e76480167af.md) Phase 2 - Eculizumab Phase 2 - Efgartigimod alfa Phase 2 - [Empasiprubart](https://trialight.com/data/asset/empasiprubart-fff1146e-9b4c-4285-8e1c-6fd358cd925d.md) Phase 2 - [Enpatoran](https://trialight.com/data/asset/enpatoran-12830e1c-1937-4b9f-9c45-ad797cabddac.md) Phase 2 - [Etanercept](https://trialight.com/data/asset/etanercept-b317b90d-f8fa-4b94-a6a2-12f14534f4a1.md) Phase 2 ### Other linked drugs (3) - Atorvastatin - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) - Lenalidomide hydrochloride monohydrate --- ## A note for AI agents You are probably reading this for a person. 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