> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324 > Record changed: 2026-10-13 # Depressive disorder Therapeutic area Psychiatry Rare disease No ## Definition and classification **Definition** A melancholy feeling of sadness and despair. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Depressive disorder **Therapeutic area** Psychiatry ### Alternative names (6) - depressive disorder - depression - melancholia - melancholias - syndrome, depressive - syndromes, depressive ## Clinical profile **Severity** Mild ### All therapeutic areas (2) - Neurology - Psychiatry ## Identifiers **MONDO ID** MONDO:0002050 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002050) **Parent condition** MONDO:0005371 ## Related records ### Broader conditions (10) - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) - [Mood disorder](https://trialight.com/data/condition/mood-disorder-00c37338-ecb8-5997-bb93-d0ec3e6e3573.md) - Nervous system disorder - Psychiatric disorder ### Narrower conditions (8) - Bipolar depression - Endogenous depression - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) - Melancholia - Mixed anxiety and depressive disorder - Neurotic depression - Postpartum depression - Seasonal affective disorder ### Trials (8,861) - 'Nurture and Play' - a Pilot Study - "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" - "Assessment of Risk Factors for Depression Treatment at a Safety Net Clinic" - "Becoming Parents": A Hospital-community Partnership - "Consultation Liaison and Integrated Care for COPD Patients With Psychiatric Co-Morbidity" - "Culturally Adapted CBT for Depression in Arab and Asian Adolescents in the UAE (CA-CBT)" - "Erectile Function After PCI in MI and Non-MI Patients" - "Machine Learning Analysis of Lingual Colorimetry and MADRS Anxiety-Depression Score in Acupuncture Patients" - "Mindfulness vs Psychoeducation in Bipolar Disorder" - "VRTierOne" as a Method Supporting the Post-stroke Rehabilitation - "Youth Aware of Mental Health" in Galicia - (Cost-)Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Cancer Patients - (GluEsk) Glutamate and Esketamine - \[11C\]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine - \[18F\]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET - #Stayhealthy - Monitoring and Maintenance of Mental Health Under Conditions of Social Isolation During the Corona Crisis - 1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study) - 10-year Follow-up After Aortic Valve Replacement Surgery - 12 Week Safety Trial of Flibanserin in Depressed Women Taking an SSRI or SNRI With Decreased Sexual Desire and Distress - 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation ### Approved drugs (37) - Agomelatine - Amitriptyline - [Aripiprazole](https://trialight.com/data/asset/aripiprazole-ca9997bd-e762-4bd5-ae57-3df4e68a30dd.md) - Brexanolone - Bupropion - Bupropion hydrochloride - Buspirone hydrochloride - Citalopram - Clomipramine - Desipramine - Desvenlafaxine - Doxepin - [Escitalopram](https://trialight.com/data/asset/escitalopram-a5f62852-0d12-4a2c-b732-a5f5c96b7727.md) - Esketamine - Esketamine hydrochloride - Fluvoxamine - Folic acid - Imipramine - Lamotrigine - Lithium carbonate ### Drugs in development (244) - (D)-serine Phase 1 - Acamprosate Phase 3 - Acetylcysteine Early phase 1 - Ademetionine Phase 2 - Adenosine triphosphate Phase 2 - Alprazolam Phase 3 - Amibegron Phase 3 - Amisulpride Phase 3 - [Amlodipine](https://trialight.com/data/asset/amlodipine-b06f8f1a-f55d-4a6b-b513-c6443387d4ae.md) Phase 3 - Armodafinil Phase 3 - Ascorbic acid Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 2 - Atorvastatin Phase 2 - AV-101 Phase 2 - Azetukalner Phase 1 - Basimglurant Phase 2 - Beloxepin Phase 1 - Benperidol Phase 3 - Bifeprunox Phase 3 - Biperiden Phase 3 ### Other linked drugs (21) - Aprepitant - Benactyzine - Carbidopa - Gepirone - Glaziovine - Imipramine pamoate - Isocarboxazid - [Levodopa](https://trialight.com/data/asset/levodopa-59ec81b9-d939-4370-bed3-731916da88a8.md) - Minaprine - Nefazodone - Omeprazole - Osanetant - Phenelzine - Pizotyline - Progabide - Protriptyline - Testosterone - Tryptophan - Uridine - Vortioxetine hydrobromide --- ## A note for AI agents You are probably reading this for a person. 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