> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/cutaneous-neuroendocrine-carcinoma-ba38e774-613b-5117-ab12-d3c4e4cf6ad8 > Record changed: 2026-10-13 # Cutaneous neuroendocrine carcinoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** Cutaneous neuroendocrine carcinoma is a primary cutaneous cancer arising from a subset of skin neuroendocrine cells (Merkel cells, giving the name Merkel cell carcinoma (MCC)). **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Cutaneous neuroendocrine carcinoma **Therapeutic area** Oncology ### Alternative names (18) - cutaneous neuroendocrine carcinoma - MCC - Merkel Cell Carcinoma - Merkel cell cancer - Merkel cell carcinoma - Merkel cell tumor - Merkel cell tumour - carcinoma of Merkel cell - cutaneous APUDoma - cutaneous neuroendocrine carcinoma - neuroendocrine carcinoma of skin - neuroendocrine carcinoma of the skin - neuroendocrine skin carcinoma - trabecular cancer - trabecular skin carcinoma - Merkle tumors - Merkle tumours - carcinoma, Merkel cell ## Clinical profile **Severity** Severe ### Disease mechanisms (2) - Acquired - Developmental ### All therapeutic areas (4) - Dermatology - Endocrinology - Neurology - Oncology ## Identifiers **MONDO ID** MONDO:0019210 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019210) **Parent condition** MONDO:0002120 ## Related records ### Broader conditions (35) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Dermis disorder - Dermis tumor - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Disorder of development or morphogenesis - Endocrine gland neoplasm - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Epithelial skin neoplasm - Human disease - Integumentary system cancer - Integumentary system disorder - Malignant dermis tumor - Malignant endocrine neoplasm ### Trials (150) - A Beta-only IL-2 ImmunoTherapY Study - A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors - A Phase I, Exploratory, Intra-patient Dose Escalation Study to Investigate the Preliminary Safety, Pharmacokinetics, and Anti-tumor Activity of Pasireotide (SOM230) s.c.Followed by Pasireotide LAR in Patients With Metastaticmelanoma or Metastatic Merkel Cell Carcinoma - A Proof-of-Concept Trial of GLA-SE in Patients With Merkel Cell Carcinoma - A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies - A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies - A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies - [A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-a-selective-t-cell-receptor-tcr-targeting-e1059f78-0eb9-40d9-943a-62719dc0e686.md) - A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors - A Study of CRD3874-SI in People With Solid Tumors - A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma - A Study of INCMGA00012 in Metastatic Merkel Cell Carcinoma (POD1UM-201) - A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer - A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21) - A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors - A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors - A Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors - A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers - [A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-to-evaluate-arv-6723-alone-and-with-pembrolizumab-in-bce3f615-48a3-4fcf-824b-1b222c4cb40e.md) - A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers ### Approved drugs (2) - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) - [Retifanlimab](https://trialight.com/data/asset/retifanlimab-57767872-c97a-4714-befa-fa3aa2ae5ce8.md) ### Drugs in development (35) - Aldesleukin Phase 1 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 1 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 1 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - [Cemiplimab](https://trialight.com/data/asset/cemiplimab-1c235a93-9b2c-4db0-9980-a78a93354b46.md) Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 - Domatinostat Phase 2 - Etoposide Phase 2 - F16IL2 Phase 2 - [Fluorouracil](https://trialight.com/data/asset/fluorouracil-f8444d73-5c73-4f35-aa71-67d578277450.md) Phase 2 - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Phase 2 - Interferon beta Phase 1 - [Ipilimumab](https://trialight.com/data/asset/ipilimumab-06c42b29-e333-4f3c-94fe-dbea5fe48cd4.md) Phase 2 - [Irinotecan hydrochloride](https://trialight.com/data/asset/irinotecan-hydrochloride-c1f6b7df-7c76-40f1-92fe-12d71b1f3b25.md) Phase 2 - Lanreotide Phase 2 - [Lenvatinib](https://trialight.com/data/asset/lenvatinib-44bdd81b-9a97-4a26-9b2b-0d1d8fd79032.md) Phase 2 - [Leucovorin calcium](https://trialight.com/data/asset/leucovorin-calcium-8da292ca-1b92-4365-b525-77d897b1c096.md) Phase 1 - Lutetium oxodotreotide LU-177 Phase 2 - [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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