> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/cushing-syndrome-bf694ab1-28dd-5b0a-bb0e-fbe035b96fed > Record changed: 2026-10-13 # Cushing syndrome Rare disease Yes ## Definition and classification **Definition** Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogenous (iatrogenic) origin. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Cushing syndrome ### Alternative names (11) - Cushing syndrome - hypercortisolism - Cushing syndrome - Cushing's syndrome - cortisol Excess - hyperadrenocorticism - pituitary basophilism - suprarenogenic syndrome - adrenal hyperfunction resulting from pituitary ACTH excess - ectopic adrenocorticotropic hormone syndrome - nodular primary adrenocortical dysplasia ## Clinical profile **Disease mechanisms** - Syndromic **Severity** Severe ## Identifiers **MONDO ID** MONDO:0018912 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018912) **Parent condition** MONDO:0002254 ## Related records ### Broader conditions (4) - Disease - Disease by body system or component - Human disease - Syndromic disease ### Narrower conditions (12) - ACTH-dependent Cushing syndrome - ACTH-independent adrenal Cushing syndrome, somatic - ACTH-independent Cushing syndrome - ACTH-independent macronodular adrenal hyperplasia 1 - ACTH-independent macronodular adrenal hyperplasia 2 - ACTH-independent macronodular adrenal hyperplasia 3 - Cushing disease due to pituitary adenoma - Cushing syndrome due to cortisol-producing adrenocortical adenoma - Cushing syndrome due to macronodular adrenal hyperplasia - Ectopic Cushing syndrome - Endogenous Cushing syndrome - Exogenous Cushing syndrome ### Trials (126) - A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement - A Prospective Cohort Study for Patients With Adrenal Diseases - A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery - A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome - A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome - A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas - A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome - A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease - A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. - A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia - A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome - Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma - Adolescence, Puberty, and Emotion Regulation - Adrenal Tumors - Pathogenesis and Therapy - Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors - Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by Glucocorticoids - An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome - Appropriate Limit Value for 1 mg DST in Patients With Chronic Renal Failure - Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery - Canadian Continuation of Roll-over Study in Patients With Endogenous Cushing's Syndrome ### Approved drugs (4) - Ketoconazole - [Levoketoconazole](https://trialight.com/data/asset/levoketoconazole-2a0d3bb3-2041-43ef-88c8-8cf814b51e4c.md) - Mifepristone - Osilodrostat phosphate ### Drugs in development (8) - Edotreotide gallium GA-68 Phase 2 - Fluorodopa F 18 Phase 2 - Metyrapone Phase 3 - Nevanimibe hydrochloride Phase 2 - Osilodrostat Phase 2 - Pasireotide Phase 2 - Relacorilant Phase 3 - [Tadalafil](https://trialight.com/data/asset/tadalafil-4b34b94f-a4f3-4c9a-a187-9910e81423ab.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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