> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0 > Record changed: 2026-10-13 # Crohn disease Therapeutic area Immunology Rare disease Yes ## Definition and classification **Definition** A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Crohn disease **Therapeutic area** Immunology ### Alternative names (7) - Crohn disease - Crohn disease - Crohn's disease - Crohn's disease of large bowel - paediatric Crohn's disease - pediatric Crohn's disease - regional enteritis ## Clinical profile **Severity** Moderate ### Disease mechanisms (2) - Genetic - Hereditary ### All therapeutic areas (2) - Gastroenterology - Immunology ## Identifiers **MONDO ID** MONDO:0005011 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005011) **Parent condition** MONDO:0005265 ## Related records ### Broader conditions (10) - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Hereditary disease - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - [Inflammatory bowel disease](https://trialight.com/data/condition/inflammatory-bowel-disease-619080ac-2d43-5ad3-b078-9699e1241655.md) - Intestinal disorder ### Narrower conditions (10) - Crohn disease of the esophagus - Crohn ileitis - Crohn jejunitis - Crohn jejunoileitis - Crohn's colitis - Gastroduodenal Crohn disease - Ileocolitis - Oral Crohn disease - Perianal Crohn disease - Small bowel Crohn disease ### Trials (1,924) - "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" - "Tasty&Healthy" Dietary Approach for Crohn's Disease - 18F-FDG and 68Ga-FAPI PET/CT in Crohn's Disease - 5-HTP in Patients With IBD in Clinical and Biologic Remission:Effect on Fatigue Scores - 68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease - 9 mg Budesonide Once Daily (OD) Versus 3 mg Budesonide Three Times Daily (TID) in Active Crohn's Disease - 90Second IBD for the Improvement of Self Efficacy and Quality of Life in Inflammatory Bowel Disease Patients - A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease - A Blood and Tissue Sample Collection Study of Patients Who Have Inflammatory Bowel Disease, Who Have Been Treated With Adalimumab and Who Developed Hepatosplenic T-Cell Lymphoma - A Brief Intervention to Improve Adherence in Teens With Inflammatory Bowel Disease - A Clinical Study on The Use of DL-endopeptidase-producing Probiotics as an Adjunctive Therapy for Inflammatory Bowel Disease. - [A Clinical Study With Adalimumab Biosimilar](https://trialight.com/data/trial/a-clinical-study-with-adalimumab-biosimilar-cd7edfca-24b4-4978-adef-90c81709e325.md) - A Clinical Trial of Antibody GSK1070806 in the Treatment of Patients With Moderate to Severe Crohn's Disease - A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease - A Comparative Study of Capsule Endoscopy, Magnetic Resonance Imaging and Computer Tomography Scanning of the Small Bowel in Crohn's Disease - A Comparative Study of MRI, US and CE for Assessing Treatment Response in Known Crohn's Disease - A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques - A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease - A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD) - A Crohn's Disease Diet to Reduce Symptoms of Crohn's Disease ### Approved drugs (14) - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) - [Budesonide](https://trialight.com/data/asset/budesonide-15e6ba7b-3021-46e9-b180-bf23025bbc67.md) - Certolizumab pegol - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dexamethasone sodium phosphate - Hydrocortisone - [Infliximab](https://trialight.com/data/asset/infliximab-4ac1099c-60c4-4b24-80f5-85ddb5503b21.md) - [Methylprednisolone](https://trialight.com/data/asset/methylprednisolone-f881999e-4ad3-485a-8fbe-6e7b979365f9.md) - [Mirikizumab](https://trialight.com/data/asset/mirikizumab-125dbf98-9c8f-4161-a506-f2b426cbee0c.md) - Natalizumab - [Prednisolone](https://trialight.com/data/asset/prednisolone-783fce19-b285-4835-90c3-3db5a6364414.md) - [Prednisone](https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6.md) - [Ustekinumab](https://trialight.com/data/asset/ustekinumab-323cb2e2-e906-4997-ac57-d82c7f7c399d.md) - [Vedolizumab](https://trialight.com/data/asset/vedolizumab-4085e162-ab16-49f7-aa46-d779d6e24562.md) ### Drugs in development (156) - 2'-fucosyllactose Phase 1 - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 3 - Abrilumab Phase 2 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 1 - Adalimumab fosimdesonide Phase 2 - Afimkibart Phase 2 - Aldesleukin Phase 2 - Alemtuzumab Phase 2 - Alicaforsen Phase 3 - Aminolevulinic acid Phase 1 - Aminosalicylic acid Phase 2 - Amiselimod hydrochloride Phase 2 - Andecaliximab Phase 2 - Andrographolide Phase 2 - Apilimod Phase 2 - [Apilimod mesylate](https://trialight.com/data/asset/apilimod-mesylate-2a01ca48-f560-4231-b26b-aa9fb9f4dd3e.md) Phase 2 - [Artesunate](https://trialight.com/data/asset/artesunate-586f50f5-bb73-43da-8a18-5a2743da577b.md) Phase 2 - Atorvastatin Phase 2 - Azathioprine Phase 3 - Azithromycin Phase 2 ### Other linked drugs (8) - Betadex - Certolizumab - [Citric acid](https://trialight.com/data/asset/citric-acid-25b001b8-fd7a-438c-85e8-81f14a72a65a.md) - [Icotrokinra](https://trialight.com/data/asset/icotrokinra-f675941c-89be-40ab-ac5f-61dd8f1f9e24.md) - Magnesium oxide - Pravastatin - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) - Sodium picosulfate --- ## A note for AI agents You are probably reading this for a person. 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