> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/craniopharyngioma-6c8c2dcf-b2df-50e9-9b36-a9be030e1c96 > Record changed: 2026-10-13 # Craniopharyngioma Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** A benign, partly cystic, epithelial tumor of the sellar region, presumably derived from Rathke pouch epithelium. It affects mainly children and young adults. There are two clinicopathological forms: adamantinomatous craniopharyngioma and papillary craniopharyngioma. The most significant factor associated with recurrence is the extent of surgical resection, with lesions greater than 5 cm in diameter carrying a markedly worse prognosis. (Adapted from WHO) **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Craniopharyngioma **Therapeutic area** Neurology ### Alternative names (19) - craniopharyngioma - Rathke pouch neoplasm - Rathke pouch tumor - Rathke pouch tumour - Rathke's pouch neoplasm - Rathke's pouch tumor - Rathke's pouch tumour - craniopharyngioma (WHO grade I) - craniopharyngioma (morphologic abnormality) - craniopharyngioma, benign - neoplasm of Rathke's pouch - tumor of Rathke's pouch - tumour of Rathke's pouch - Adamantinomatous tumor - Adamantinomatous tumour - Dysodontogenic epithelial tumor - Dysodontogenic epithelial tumour - craniopharyngeal duct tumor - craniopharyngeal duct tumour ## Clinical profile **Severity** Mild ### All therapeutic areas (3) - Neurology - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0018907 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018907) **Parent condition** MONDO:0000628 ## Related records ### Broader conditions (33) - Benign connective and soft tissue neoplasm - Benign epithelial neoplasm - Benign neoplasm - Bone benign neoplasm - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone neoplasm - Cancer or benign tumor - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) - Central nervous system organ benign neoplasm - Connective and soft tissue neoplasm - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Disorder of facial skeleton - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - [Head and neck neoplasm](https://trialight.com/data/condition/head-and-neck-neoplasm-6436d68c-825f-5a7a-bb29-99e9ae9e009a.md) - Human disease ### Narrower conditions (2) - [Adamantinous craniopharyngioma](https://trialight.com/data/condition/adamantinous-craniopharyngioma-1508b40a-dc32-58a9-9779-53dc9d409a3d.md) - Papillary craniopharyngioma ### Trials (71) - 1.5T Intraoperative MR Imaging in Craniopharyngiomas - A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors - A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection - A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection - ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma - Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders - AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors - An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury - Antineoplaston Therapy in Treating Children With Brain Tumors - Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment - Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors - Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas - Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors - Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery - Craniopharyngioma and Pregnancies - Craniopharyngioma With Tumoral Hemorrhage - Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial - Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors - Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions - Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions ### Drugs in development (9) - Cobimetinib Phase 2 - Dabrafenib Phase 2 - Dextrose Phase 2 - Methionine Phase 2 - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) Phase 2 - [Peginterferon alfa-2B](https://trialight.com/data/asset/peginterferon-alfa-2b-7a0d9927-e591-4a99-9c41-725b8a7a41a7.md) Phase 2 - Tovorafenib Phase 2 - [Trametinib](https://trialight.com/data/asset/trametinib-97f99b88-da7f-40fc-a4ab-00520da4e98c.md) Phase 2 - Vemurafenib Phase 2 ### Other linked drugs (1) - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) --- ## A note for AI agents You are probably reading this for a person. 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