> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a > Record changed: 2026-10-13 # Colorectal carcinoma Therapeutic area Gastroenterology Rare disease No ## Definition and classification **Definition** A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Colorectal carcinoma **Therapeutic area** Gastroenterology ### Alternative names (19) - colorectal carcinoma - cancer of large bowel - cancer of large intestine - cancer of the large bowel - cancer of the large intestine - colorectal (colon or rectal) cancer - colorectal cancer - large bowel cancer - large intestine cancer - CRC - carcinoma of colorectum - carcinoma of large bowel - carcinoma of large intestine - carcinoma of the large bowel - carcinoma of the large intestine - colorectal carcinoma - colorectum carcinoma - large bowel carcinoma - large intestine carcinoma ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Gastroenterology - Oncology ## Identifiers **MONDO ID** MONDO:0024331 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024331) **Parent condition** MONDO:0005575 ## Related records ### Broader conditions (20) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) - [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) - Digestive system cancer - Digestive system carcinoma - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - [Digestive system neoplasm](https://trialight.com/data/condition/digestive-system-neoplasm-2ebb9146-1d78-515a-92a3-749515a27d44.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Human disease - Intestinal cancer - Intestinal disorder - Intestinal neoplasm - Large intestine disorder - Neoplasm - Neoplastic disease or syndrome ### Narrower conditions (57) - Adenosquamous colon carcinoma - Anal canal adenocarcinoma - Anal canal carcinoma - Anal canal carcinoma in situ - Anal canal neuroendocrine neoplasm - Anal canal Paget disease - Anal canal squamous cell carcinoma - [Anal carcinoma](https://trialight.com/data/condition/anal-carcinoma-d0dca5aa-14ee-5bcc-8bd1-2a2539daa2ec.md) - Anal gland adenocarcinoma - Anal margin basal cell carcinoma - Anal margin carcinoma - Anal margin squamous cell carcinoma - Anal mucinous adenocarcinoma - Anal Paget disease - Anal squamous cell carcinoma - Anal verrucous carcinoma - Anus adenocarcinoma - Anus basaloid carcinoma - Appendix adenocarcinoma - Appendix carcinoma ### Trials (501) - 4SC-201 (Resminostat) in Advanced Colorectal Carcinoma - 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - A Biomarker Exploration Study for Predicting Localization of Recurrence and Metastasis in Colorectal Cancer (PROBE Study) - A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers - A Clinical Study of Iparomlimab and Tuvonralimab Combined With Bevacizumab and Alternating Triweekly CAPOX/mCAPIRI Regimen as First-line Treatment for Unresectable Advanced Colorectal Cancer - A Clinical Study of Iparomlimab and Tuvonralimab Combined With Fruquintinib and Heterogeneous Radiotherapy Versus Fruquintinib as Third-Line and Subsequent-Line Treatment for Metastatic Colorectal Cancer - A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer - A Clinical Study on the Treatment of Metastatic Colorectal Cancer at the Second-line or Beyond. - A Clinical Study to Evaluate the Efficacy and Safety of Envafolimab Combined With Cetuxima-βand mFOLFOX6 in Patients With MSS, RAS/BRAF Wild-Type Metastatic Colorectal Cancer (mCRC) - A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome - A Community-Based Educational Intervention to Improve Colorectal Cancer Screening - A Dietary Intervention (Soy Soft Pretzels) for Reducing Chronic Inflammation in Obese Individuals - A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors - A Dose Escalation Study of APR003 in Patients With Advanced Colorectal Cancer (CRC) With Malignant Liver Lesions - A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors - A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Products - A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors. - A Multilevel Approach for Improvement in Screening of Colorectal Cancer in Rural Communities, The Screen to Save Trial - A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immunochemical Test Results, PROACT Trial ### Approved drugs (12) - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) - [Cetuximab](https://trialight.com/data/asset/cetuximab-a1f8c65c-bae1-4b77-9491-dca37aeeaa3c.md) - [Ipilimumab](https://trialight.com/data/asset/ipilimumab-06c42b29-e333-4f3c-94fe-dbea5fe48cd4.md) - [Levoleucovorin](https://trialight.com/data/asset/levoleucovorin-fdff57d9-ad4f-4a44-ad7d-40932f268d1b.md) - [Levoleucovorin calcium](https://trialight.com/data/asset/levoleucovorin-calcium-21e918a4-89ff-4c55-aafc-3b4fd0086bc6.md) - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) - [Panitumumab](https://trialight.com/data/asset/panitumumab-ea8dc0f1-ea1f-4586-b6ad-68fc23ba56f1.md) - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) - [Tipiracil hydrochloride](https://trialight.com/data/asset/tipiracil-hydrochloride-c5072dfa-12fa-4ccc-9e35-c488a67c9673.md) - [Trifluridine](https://trialight.com/data/asset/trifluridine-cf1f965b-3efb-4c26-a766-cb4c7c73675f.md) - [Tucatinib](https://trialight.com/data/asset/tucatinib-79f88fe2-698e-4d56-aaf9-f0c4927094ba.md) ### Drugs in development (59) - Abituzumab Phase 1 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 3 - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 2 - Axitinib Phase 2 - Berzosertib Phase 1 - [Binimetinib](https://trialight.com/data/asset/binimetinib-f5914744-65e2-4d8c-8482-9f51a406315e.md) Phase 2 - Bortezomib D-mannitol Phase 2 - [Cadonilimab](https://trialight.com/data/asset/cadonilimab-3970701f-ffc8-4027-a97b-4e6c913803e6.md) Phase 2 - Calcium Phase 3 - Camrelizumab Phase 2 - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) Phase 3 - Clobetasol propionate Phase 2 - Cobimetinib Phase 3 - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) Phase 2 - Dolcanatide Phase 1 - [Dostarlimab](https://trialight.com/data/asset/dostarlimab-aad06b17-e988-4591-813f-4b6cef63860f.md) Phase 2 - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) Phase 2 - [Durvalumab](https://trialight.com/data/asset/durvalumab-bca7c265-7862-46e1-bf29-3dd2fdda4954.md) Phase 2 - [Fluorouracil](https://trialight.com/data/asset/fluorouracil-f8444d73-5c73-4f35-aa71-67d578277450.md) Phase 3 - [Fruquintinib](https://trialight.com/data/asset/fruquintinib-e15c1522-cabe-4f7b-a918-3ca55e1ef88a.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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