> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/cloves-syndrome-9c141b14-8406-58d4-b912-9fc8302ab635
> Record changed: 2026-10-13

# CLOVES syndrome

Therapeutic area

Dermatology

Rare disease

Yes

## Definition and classification

**Definition**

A syndromic disease characterized by Congenital Lipomatous Overgrowth, progressive, complex and mixed truncal Vascular malformations, Epidermal nevi, and Skeletal anomaly.

**Genetic basis**

Yes

**Non-human condition**

No

**Rare disease**

Yes

**Listing at source**

Listed

**Condition name**

CLOVES syndrome

**Therapeutic area**

Dermatology

### Alternative names (7)

- CLOVES syndrome
- CLOVE syndrome, somatic
- CLOVES syndrome
- congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
- congenital lipomatous overgrowth-vascular malformation-epidermal nevi-skeletal anomaly syndrome
- congenital lipomatous overgrowth-vascular malformation-epidermal nevi-spinal anomaly syndrome
- congenital lipomatous overgrowth - vascular malformation - epidermal nevi

## Clinical profile

**Severity**

Severe

### Disease mechanisms (4)

- Developmental
- Genetic
- Hereditary
- Syndromic

### All therapeutic areas (2)

- Dermatology
- Oncology

## Identifiers

**MONDO ID**

MONDO:0013038

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0013038)

**Parent condition**

MONDO:0002254

## Related records

### Broader conditions (26)

- Benign neoplasm
- Benign neoplasm of skin
- Cancer or benign tumor
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Disorder of development or morphogenesis
- Hereditary disease
- [Hereditary skin disorder](https://trialight.com/data/condition/hereditary-skin-disorder-f5d8c433-73e1-52b2-8b9a-f3ca836efe24.md)
- Human disease
- Integumentary system benign neoplasm
- Integumentary system disorder
- Melanocytic neoplasm
- Melanocytic nevus
- Melanocytic skin neoplasm
- Neoplasm
- Neoplastic disease or syndrome
- Neurocristopathy

### Trials (6)

- [A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)](https://trialight.com/data/trial/a-phase-2-study-of-mutant-selective-pi3k-inhibitor-rly-2608-cb48d7d4-b39e-48fc-b89b-e54745cb8b7c.md)
- A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome
- Identification of Biomarkers for Patients with Vascular Anomalies
- Lymphatic Anomalies Registry for the Assessment of Outcome Data
- National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)
- Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the Periphery

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