> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/classic-familial-adenomatous-polyposis-3e5f34e5-9319-567e-8ab8-cb7bb898a156 > Record changed: 2026-10-13 # Classic familial adenomatous polyposis Rare disease Yes ## Definition and classification **Definition** Familial adenomatous polyposis (FAP) is characterized by the development of hundreds to thousands of adenomas in the rectum and colon during the second decade of life. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Classic familial adenomatous polyposis ### Alternative names (18) - classic familial adenomatous polyposis - FAP - Familial Adenomatous Polyposis - adenomatous polyposis coli - classic FAP - classic familial adenomatous polyposis - colorectal adenomatous polyposis - familial adenomatous polyposis - familial adenomatous polyposis coli - familial adenomatous polyposis syndrome - familial polyposis - familial polyposis coli - hereditary adenomatous polyposis coli - polyposis coli - FPC - familial adenomatous polyposis of the colon - familial multiple polyposis - hereditary polyposis coli ## Clinical profile **Severity** Severe ### Disease mechanisms (3) - Genetic - Hereditary - Syndromic ## Identifiers **MONDO ID** MONDO:0021055 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0021055) **Parent condition** MONDO:0021057 ## Related records ### Broader conditions (15) - Cancer or benign tumor - Classic or attenuated familial adenomatous polyposis - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Disease susceptibility - Hereditary disease - Hereditary neoplastic syndrome - Human disease - Inherited disease susceptibility - Intestinal polyposis syndrome - Neoplastic disease or syndrome - Neoplastic syndrome - Syndromic disease ### Narrower conditions (3) - Familial adenomatous polyposis due to 5q22.2 microdeletion - Gardner syndrome - Turcot syndrome with polyposis ### Trials (109) - 18F-FAPI PET in the Diagnosis of Liver Fibrosis - 18F-FAPI-04 PET/CT and PET/MR in Patients With Various Types of Malignant Tumors - 18F-FES PET/CT in Imaging Patients With Desmoid Tumors - 68Ga-FAPI-LM3 PET/CT Imaging in Patients With FAP/SSTR2 Positive Disease and Compared With 18F-FDG - 68Ga-PSFA PET Imaging in Patients With PSMA/FAP Positive Disease - A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients - A Clinical Trial of the Effectiveness and Safety of Software Assisting Diagnose the Intestinal Polyp Digestive Endoscopy by Analysis of Colonoscopy Medical Images From Electronic Digestive Endoscopy Equipment - A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis - A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy - A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). - A Study of Guselkumab in Participants With Familial Adenomatous Polyposis - A Study of JNJ-64251330 in Participants With Familial Adenomatous Polyposis - A Study of Rofecoxib in Familial Adenomatous Polyposis (FAP) (0966-205)(TERMINATED) - A Study to Evaluate the Safety and Preliminary Signs of Efficacy of \[177Lu\]Lu-OncoFAP-23 Alone or in Combination With L19-IL2 as a Treatment of Metastatic FAP-positive Solid Tumors - A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP) - Adenoma Detection Rate:NBI, AFI, Chromoscopic or Standard Endoscopy - An Evaluation of SprayShield in Reducing Post-Operative Adhesion Formation Following Major Open Abdominal Surgery - An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis - Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions - Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis ### Approved drugs (1) - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) ### Drugs in development (22) - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 1 - Calcitriol Phase 3 - [Calcium carbonate](https://trialight.com/data/asset/calcium-carbonate-37e10d9b-34b0-4b9a-ad7f-b08adfd15b03.md) Phase 3 - Curcumin Phase 2 - Eflornithine Phase 3 - Eflornithine hydrochloride Phase 3 - Eflornithine, (S)- Phase 3 - Erlotinib Phase 2 - Erlotinib hydrochloride Phase 2 - [Guselkumab](https://trialight.com/data/asset/guselkumab-90846a1b-25ed-4e53-ae9c-4730391bc3c9.md) Phase 1 - Icosapent Phase 3 - Inulin Phase 2 - Lactobacillus acidophilus Phase 2 - Lithium carbonate Phase 2 - Metformin Phase 2 - Niclosamide Phase 2 - Obeticholic acid Phase 1 - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 2 - Sulindac Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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