> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/chronic-progressive-multiple-sclerosis-99de35e9-2d98-5ec1-815e-693482f47d80 > Record changed: 2026-10-13 # Chronic progressive multiple sclerosis Therapeutic area Immunology Rare disease No ## Definition and classification **Definition** A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914) **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Chronic progressive multiple sclerosis **Alternative names** - chronic progressive multiple sclerosis **Therapeutic area** Immunology ## Clinical profile **Disease mechanisms** - Developmental **Severity** Severe ### All therapeutic areas (2) - Immunology - Neurology ## Identifiers **MONDO ID** MONDO:0005284 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005284) **Parent condition** MONDO:0005301 ## Related records ### Broader conditions (17) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - Autoimmune disorder of central nervous system - Autoimmune disorder of the nervous system - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - CNS demyelinating autoimmune disease - Demyelinating disease - Demyelinating disease of central nervous system - Disease - Disease by body system or component - Disease by developmental or physiological process - Disorder of development or morphogenesis - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) ### Narrower conditions (3) - Primary progressive multiple sclerosis - [Progressive relapsing multiple sclerosis](https://trialight.com/data/condition/progressive-relapsing-multiple-sclerosis-3988455b-b8b3-5584-a1f4-703f7fdd9533.md) - [Secondary progressive multiple sclerosis](https://trialight.com/data/condition/secondary-progressive-multiple-sclerosis-c559b49a-e39f-545b-aab5-dd41263dd2f6.md) ### Trials (237) - "Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS - 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis. - A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients - A Basket Study of CTA313 in Participants With Active Autoimmune Diseases - A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosis - A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Autoimmune Diseases - A First-in-human, Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis - A Long-term Follow-up Study Of Multiple Sclerosis Patients Who Participated In Genzyme-sponsored Studies of GZ402668 - A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease - A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients - A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo - A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis - A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis - A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis - A Real-world Study About the Impact of Siponimod Treatment on Secondary Progressive Multiple Sclerosis Patients in Russia - A Real-world Study to Assess the Use of Siponimod in Spain to Treat Patients With Secondary Progressive Multiple Sclerosis - A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis - A Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis - A Study for Patients With Multiple Sclerosis - A Study for Patients With Secondary Progressive Multiple Sclerosis ### Approved drugs (3) - [Ocrelizumab](https://trialight.com/data/asset/ocrelizumab-88f6b89d-011b-4db2-af88-51414e00e847.md) - Siponimod fumaric acid - [Ublituximab](https://trialight.com/data/asset/ublituximab-3c9899a4-b048-41b6-a488-c8af00eca6d3.md) ### Drugs in development (30) - Acetylcysteine Phase 2 - Cladribine Phase 2 - Clemastine fumarate Phase 1 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - Debamestrocel Phase 2 - Dimethyl fumarate Phase 3 - Dirucotide Phase 3 - Domperidone Phase 2 - Fenebrutinib Phase 3 - Ferumoxytol Early phase 1 - Fingolimod Phase 3 - Gadoteridol Early phase 1 - Glatiramer acetate Phase 2 - Hydroxychloroquine Phase 2 - Ibudilast Phase 2 - [Indapamide](https://trialight.com/data/asset/indapamide-38f48c91-8217-4462-9f68-aacc5047dd2a.md) Phase 2 - [Insulin human](https://trialight.com/data/asset/insulin-human-99c024c5-521b-478f-a4e1-d5705d2c66d8.md) Phase 1 - Insulin pork Phase 1 - Interferon beta Phase 1 - Liothyronine Phase 1 ### Other linked drugs (2) - Interferon beta-1B - Siponimod --- ## A note for AI agents You are probably reading this for a person. 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