> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f > Record changed: 2026-10-13 # Chronic obstructive pulmonary disease Therapeutic area Pulmonology Rare disease No ## Definition and classification **Definition** A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema. **Genetic basis** Yes **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Chronic obstructive pulmonary disease **Therapeutic area** Pulmonology ### Alternative names (14) - chronic obstructive pulmonary disease - COLD - COPD - COPD, chronic obstructive pulmonary disease - chronic obstructive airways disease - chronic obstructive lung disease - chronic obstructive pulmonary disease (COPD) - chronic obstructive pulmonary disease, (COPD) - cold - cold (chronic obstructive lung disease) - disease (COPD), chronic obstructive - obstructive lung disease, chronic - obstructive pulmonary disease (COPD), chronic - pulmonary disease (COPD), chronic obstructive ## Clinical profile **All therapeutic areas** - Pulmonology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0005002 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005002) **Parent condition** MONDO:0002267 ## Related records ### Broader conditions (9) - Disease - Disease by body system or component - Human disease - [Lower respiratory tract disorder](https://trialight.com/data/condition/lower-respiratory-tract-disorder-cfa96f5e-8af8-555b-a663-55befbd68962.md) - [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) - Obstructive lung disease - Respiratory system disorder - Tracheal disorder - Upper respiratory tract disorder ### Narrower conditions (14) - [Bronchiectasis](https://trialight.com/data/condition/bronchiectasis-8d498aad-545e-518d-b298-07bc2c8370b0.md) - Bronchiectasis with or without elevated sweat chloride 1 - Bronchiectasis with or without elevated sweat chloride 2 - Bronchiectasis with or without elevated sweat chloride 3 - [Chronic bronchitis](https://trialight.com/data/condition/chronic-bronchitis-1182c6a7-3657-5c56-89e7-6c969a2220da.md) - Compensatory emphysema - Congenital lobar emphysema - [COPD, severe early onset](https://trialight.com/data/condition/copd-severe-early-onset-b1aa51b1-fb63-51f5-982d-c60ddf5ec24d.md) - Diffuse panbronchiolitis - Emphysema, hereditary pulmonary - Hyperlucent lung - Idiopathic bronchiectasis - Interstitial emphysema - [Pulmonary emphysema](https://trialight.com/data/condition/pulmonary-emphysema-7c09e667-0ffb-5ac1-bbd4-bd87b4f05fc6.md) ### Trials (3,928) - : Vascular Function in Health and Disease - 'Real Life' Monitoring of COPD no ICS Patients - "Consultation Liaison and Integrated Care for COPD Patients With Psychiatric Co-Morbidity" - "The Effect of Inhaled Nitroglycerin for COPD Patients - 1-year Study to Assess the Efficacy, Safety, and Tolerability of Glycopyrronium Bromide (NVA237) in Chronic Obstructive Pulmonary Disease (COPD) - 12-week Efficacy of Indacaterol - 12-week Open-label Evaluation of Efficacy and Safety of Indacaterol - 129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation - 14729-D9831C00002- 1 Month Biopsy Study - 15-year Mortality After Hospitalization for Exacerbation of Chronic Obstructive Pulmonary Disease - 2-arm Parallel Group Study of Fixed Combination of CHF 5993 vs Ultibro® in COPD Patients - 24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003 and Placebo MDI - 24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003, Open-Label Spiriva® Respimat® as an Active Control, and Placebo - 26 Week Efficacy, Safety and Tolerability Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD) - 3 Minutes Chair Rise Test (3CRT) in Patients With COPD - 3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF - 4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting - 6-minute Stepper Test and Pulmonary Rehabilitation in Patients With Chronicle Obstructive Pulmonary Disease - 6-minute Stepper Test and Pulmonary Rehabilitation in Patients With Severe to Very Severe Chronicle Obstructive Pulmonary Disease - 7 Days of TD-4208 in Subjects With Chronic Obstructive Pulmonary Disease ### Approved drugs (22) - Aclidinium bromide - Albuterol - [Albuterol sulfate](https://trialight.com/data/asset/albuterol-sulfate-2dd2d404-b0a0-4c65-9f6e-2fa1ab444b30.md) - Arformoterol tartrate - Azithromycin - [Budesonide](https://trialight.com/data/asset/budesonide-15e6ba7b-3021-46e9-b180-bf23025bbc67.md) - [Ensifentrine](https://trialight.com/data/asset/ensifentrine-0ba755a4-e4b3-4f85-bafa-abd450e78bd9.md) - Fluticasone furoate - Fluticasone propionate - [Formoterol fumarate](https://trialight.com/data/asset/formoterol-fumarate-235f1f49-5d38-4e21-b612-da2d6d446b33.md) - [Glycopyrronium bromide](https://trialight.com/data/asset/glycopyrronium-bromide-3e811428-27d6-4276-96b9-b0b17847e0e3.md) - Glycopyrronium tosylate - Indacaterol maleate - Ipratropium bromide - Olodaterol hydrochloride - Prednisolone sodium phosphate - Revefenacin - Roflumilast - Salmeterol xinafoate - [Tiotropium bromide](https://trialight.com/data/asset/tiotropium-bromide-4410d294-ab42-468c-af96-801b721fb9bd.md) ### Drugs in development (230) - .ALPHA.1-proteinase inhibitor human Phase 3 - [Abediterol](https://trialight.com/data/asset/abediterol-53a77fb7-0b78-4d57-99f8-2c8f24715a70.md) Phase 2 - Acetazolamide Phase 3 - Acetylcysteine Phase 3 - Aclidinium Phase 2 - Acumapimod Phase 2 - Aderamastat Phase 1 - [Albumin human](https://trialight.com/data/asset/albumin-human-95414b67-0d38-49d4-91b2-27b1c6c17389.md) Phase 3 - Alvelestat Phase 2 - Amelubant Phase 2 - Amikacin Early phase 1 - Amikacin sulfate Phase 3 - Andecaliximab Phase 1 - Anti-psgl-1 antibody SELK2 Phase 2 - Apocynin Phase 1 - Arformoterol Phase 3 - Arofylline Phase 3 - ASM-024 Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - [Astegolimab](https://trialight.com/data/asset/astegolimab-29ef649e-0460-44f8-91da-cd089a34950c.md) Phase 3 ### Other linked drugs (19) - Almitrine - Aprepitant - Bamifylline - Beclomethasone - Bitolterol - Carbocysteine - Curcumin - Ergocalciferol - Fentanyl - Fentanyl citrate - Fluorometholone - Levcromakalim - Meprednisone - Pimagedine - Prasterone - [Pregabalin](https://trialight.com/data/asset/pregabalin-c76529d4-1815-46a3-954e-cf21d394857b.md) - [Stapokibart](https://trialight.com/data/asset/stapokibart-cf91b0c3-2312-4ec3-934f-c6f1ea95d567.md) - Telenzepine - Zardaverine --- ## A note for AI agents You are probably reading this for a person. 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