> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/choroidal-neovascularization-5e4d725e-9e65-52d5-8a90-0001a1196b7f > Record changed: 2026-10-13 # Choroidal neovascularization Therapeutic area Ophthalmology Rare disease No ## Definition and classification **Definition** An eye disorder described by the growth of new blood vessels that originate from the choroid through a break in the Bruch membrane into the sub–retinal pigment epithelium (sub-RPE) or subretinal space. Choroidal neovascularization (CNV) is a major cause of visual loss. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Choroidal neovascularization **Alternative names** - choroidal neovascularization **Therapeutic area** Ophthalmology ## Clinical profile **All therapeutic areas** - Ophthalmology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0810000 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0810000) **Parent condition** MONDO:0005328 ## Related records ### Broader conditions (6) - Disease - Disease by body system or component - Disorder of orbital region - Disorder of visual system - Eye disorder - Human disease ### Trials (202) - 20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD) - A 16 Week Evaluation of the Novartis Health Management Tool (HMT) in Age Related Macular Degeneration (AMD) - [A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)](https://trialight.com/data/trial/a-clinical-trial-of-eye201-mk-8748-in-people-with-macular-90b89db5-5302-42fb-ba5b-3d3437205ca8.md) - [A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)](https://trialight.com/data/trial/a-clinical-trial-of-eye201-mk-8748-in-people-with-macular-ea138d8e-cfd4-45eb-a9cb-06686d6d126d.md) - A Depot Formulation of Sunitinib Malate (GB-102) Compared to Aflibercept in Subjects With Wet AMD - A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration - A Dose Escalation Trial of an Intravitreal Injection of Sirna-027 in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) - A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Either Avastin® or Eylea® Compared to Avastin® or Eylea® Monotherapy - A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® Monotherapy - A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® Monotherapy - A Population-based Study of Macular Choroidal Neovascularization in a Chinese Population - A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) - A Randomized, Double-masked, Multicenter, Controlled Study of Intravitreal KH902 in Patients With Neovascular AMD - A Randomized, Double-masked, Multicenter,Sham-controlled, Safety and Efficacy Study of KH902 in Patients With Wet AMD - A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around the Eye - A Safety and Efficacy Study Comparing the Combination Treatments of Verteporfin Therapy Plus One of Two Different Doses of Intravitreal Triamcinolone Acetonide and the Verteporfin Therapy Plus Intravitreal Pegaptanib - A Safety Study in Healthy Volunteers to Evaluate Safety, How Fast the Drug is Absorbed, and the Side Effects of the Drug in Humans - A Study Assessing the Safety and Efficacy of Multiple Intravitreal KH902 in Patients With CNV Due to AMD - A Study Of Early Markers Of Choroidal Neovascularization - A Study of the Criteria Establishing the Need for Re-treatment With Ranibizumab Upon Relapse in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia. ### Approved drugs (1) - [Ranibizumab](https://trialight.com/data/asset/ranibizumab-2ca53f2a-3d69-417e-a84c-3f9e436c1913.md) ### Drugs in development (17) - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) Phase 2 - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Phase 3 - AGN-211745 Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 3 - Brolucizumab Phase 3 - Daclizumab Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 2 - [Faricimab](https://trialight.com/data/asset/faricimab-499c6bdf-255b-4e85-beb1-4b97ebbeaf6f.md) Phase 2 - Fosbretabulin disodium Phase 1 - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Phase 1 - [Infliximab](https://trialight.com/data/asset/infliximab-4ac1099c-60c4-4b24-80f5-85ddb5503b21.md) Phase 2 - Pegaptanib octasodium Phase 3 - Pegaptanib sodium Phase 2 - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 2 - TG100-801 Phase 2 - Triamcinolone acetonide Phase 3 - Verteporfin Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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