> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/central-nervous-system-cancer-14789751-67f7-557a-9c07-30e51513747d > Record changed: 2026-11-04 # Central nervous system cancer Therapeutic area Neurology Rare disease No ## Definition and classification **Definition** A malignant neoplasm involving the central nervous system **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Central nervous system cancer **Therapeutic area** Neurology ### Alternative names (36) - central nervous system cancer - Brain and Central Nervous System Tumors - cancer of central nervous system - cancer of CNS - cancer of the central nervous system - cancer of the CNS - central nervous system neoplasms, malignant - central nervous system tumours - CNS cancer - CNS malignant neoplasms - CNS neoplasms, malignant - malignant central nervous system neoplasm - malignant central nervous system tumor - malignant central nervous system tumour - malignant CNS neoplasm - malignant CNS neoplasms - malignant CNS tumor - malignant CNS tumour - malignant neoplasm of central nervous system - malignant neoplasm of CNS - malignant neoplasm of the central nervous system - malignant neoplasm of the CNS - malignant tumor of central nervous system - malignant tumor of CNS - malignant tumor of the central nervous system And 11 more, listed on the interactive page. ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Neurology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002714) ## Identifiers **MONDO ID** MONDO:0002714 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002714) **Parent condition** MONDO:0005872 ## Related records ### Broader conditions (13) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Central nervous system neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Human disease - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplastic disease or syndrome - Nervous system cancer - [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md) - Nervous system neoplasm ### Narrower conditions (233) - ACTH-producing pituitary gland carcinoma - Adult anaplastic ependymoma - Adult brain ependymoma - Adult brainstem astrocytoma - Adult brainstem glioma - Adult brainstem gliosarcoma - Adult brainstem mixed glioma - Adult central nervous system choriocarcinoma - Adult central nervous system embryonal carcinoma - Adult central nervous system germinoma - Adult central nervous system mixed germ cell tumor - Adult central nervous system primitive neuroectodermal neoplasm - Adult embryonal tumor with multilayered rosettes, c19mc-altered - Adult glioblastoma - Adult intracranial malignant hemangiopericytoma - Adult leptomeningeal melanoma - Adult malignant schwannoma - Adult oligodendroglioma - Adult pineoblastoma - Adult spinal cord ependymoma ### Trials (707) - 18-F-Fluoroacetate as PET Imaging Agent - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas - 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. - A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery - A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors - A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement - A Multi-Center Phase I Study of Intravenous Deforolimus (AP23573, MK-8669) Administered QDX5 Every Other Week in Pediatric Patients With Advanced Solid Tumors (8669-028)(COMPLETED) - A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. - A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma - A Phase I Trial Using Combination Irinotecan and Thalidomide for Recurrent CNS Tumors - A Pilot Study of 18F-FLT in Pediatric Patients With Central Nervous System (CNS) Tumors - A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma - A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors - A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects - A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling - A Study of Avutometinib for People With Solid Tumor Cancers - A Study of Metabolic Agents Following Brain Radiation - A Study of Mirdametinib in People With Central Nervous System Tumors - A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors ### Approved drugs (1) - [Temozolomide](https://trialight.com/data/asset/temozolomide-3fac1b09-bcc5-4875-871e-2cc6460dc731.md) ### Drugs in development (87) - 4-demethyl-4-cholesteryloxycarbonylpenclomedine Phase 2 - 6-O-benzylguanine Phase 1 - Alectinib Phase 1 - Amxt-1501 dicaprate Phase 1 - Antineoplaston A10 Phase 2 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 2 - Avapritinib Phase 1 - [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) Phase 1 - Belvarafenib Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) Phase 1 - Busulfan Phase 2 - [Cabazitaxel](https://trialight.com/data/asset/cabazitaxel-9437ae6b-3713-457c-b52b-a71e10a81dde.md) Phase 1 - [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md) Phase 2 - Camonsertib Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - Carmustine Phase 1 - Cediranib maleate Phase 1 - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) Phase 2 - [Cemiplimab](https://trialight.com/data/asset/cemiplimab-1c235a93-9b2c-4db0-9980-a78a93354b46.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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