> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/bipolar-disorder-a61ecd6f-6fb9-5323-bc0d-ebf861411d3c > Record changed: 2026-11-04 # Bipolar disorder Therapeutic area Psychiatry Rare disease No ## Definition and classification **Definition** A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Bipolar disorder **Therapeutic area** Psychiatry ### Alternative names (21) - bipolar disorder - Bipolar Disorder, Current Episode Manic Severe With Psychotic Features - Bipolar Disorder, Currently in Remission - Bipolar Disorder, Depressed - Bipolar Disorder, Mania - Bipolar Disorder, Manic - Bipolar Disorder, NOS - Bipolar Disorder, Pediatric - Bipolar Disorder, Recovery - Bipolar Disorders - major affective disorder - Manic Depression - Manic Disorder - manic-depression - bipolar depression - bipolar disorder manic phase - manic bipolar affective disorder - manic bipolar I disorder - manic depressive disorder - mixed bipolar disorder - MAFD ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Neurology - Psychiatry Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004985) ## Identifiers **MONDO ID** MONDO:0004985 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004985) **Parent condition** MONDO:0005371 ## Related records ### Broader conditions (10) - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) - [Mood disorder](https://trialight.com/data/condition/mood-disorder-00c37338-ecb8-5997-bb93-d0ec3e6e3573.md) - [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md) - [Psychiatric disorder](https://trialight.com/data/condition/psychiatric-disorder-26a422d1-1076-53d2-9858-6cb1cac40a21.md) ### Narrower conditions (13) - Bipolar depression - [Bipolar I disorder](https://trialight.com/data/condition/bipolar-i-disorder-b1dec369-e9f7-586d-ad11-b8275f20481f.md) - Bipolar II disorder - Major affective disorder 1 - Major affective disorder 2 - Major affective disorder 3 - Major affective disorder 4 - Major affective disorder 5 - Major affective disorder 6 - Major affective disorder 7 - Major affective disorder 8 - Major affective disorder 9 - Manic bipolar affective disorder ### Trials (1,712) - 'Thriving With Bipolar Disorder': Co-design and Evaluation of a Peer-Led Education Program Focused on Quality of Life - "MenPhys: Intervention Protocol for Physical Wellness in Mental Health" - "Mindfulness vs Psychoeducation in Bipolar Disorder" - "Pilot Study of Music Intervention for Recovery of People With Severe Mental Disorder in the Community" - 12 Week Study of the Safety/Efficacy of Asenapine When Added to Lithium/Valproate in the Treatment of Bipolar Disorder (A7501008 / P05844 / MK-8274-017) - 12- Week Open Label Treatment of Refractory Bipolar Depression - 12-Month Extension Study of Dialectical Behavior Therapy for Youth With Bipolar Disorder - 12-Week Study Evaluating the Efficacy, Safety, and Tolerability of Adjunctive Infliximab for Bipolar I/II Depression - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression - 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder - 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation - 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008) - 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009) - 3-week Study to Evaluate Efficacy and Safety of Ziprasidone With Either Lithium or Divalproex in Acutely Manic Subjects - 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) - 40 Week Trial to Study the Safety of Asenapine When Added to Lithium or Valproate in the Treatment of Bipolar Disorder (A7501009)(P05786) - 8 Week Multi-site Study of MYDAYIS® for Bipolar Depression - 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED) - A 12-weeks Study to Evaluate the Dietary Fiber and Probiotics Treatment in Prevention and Intervention of Weight-gain and Cognitive Impairment of Schizophrenia or Bipolar Disorder - A Biological Signature for the Early Differential Diagnosis of Psychosis ### Approved drugs (24) - Acetophenazine - Acetophenazine maleate - [Aripiprazole](https://trialight.com/data/asset/aripiprazole-ca9997bd-e762-4bd5-ae57-3df4e68a30dd.md) - Asenapine - Asenapine maleate - Carbamazepine - Cariprazine hydrochloride - Divalproex sodium - Doxepin hydrochloride - Fluoxetine hydrochloride - [Lamotrigine](https://trialight.com/data/asset/lamotrigine-a3f82366-2b43-4bea-99ed-5496f51ebe15.md) - Levomepromazine - Lithium carbonate - Lithium citrate - Loxapine - Loxapine hydrochloride - Lurasidone hydrochloride - [Olanzapine](https://trialight.com/data/asset/olanzapine-5b966c11-69ff-43ab-aefa-6c712a56b2d4.md) - Quetiapine fumarate - Risperidone ### Drugs in development (168) - ABX-002 Phase 2 - Acetylcarnitine Phase 2 - Acetylcysteine Phase 2 - Alcohol Phase 2 - Aldesleukin Phase 2 - [Allopurinol](https://trialight.com/data/asset/allopurinol-31075c5e-c121-4498-9ea1-d2c48b7a7267.md) Phase 3 - Amisulpride Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - [Aticaprant](https://trialight.com/data/asset/aticaprant-5a0c94c9-c664-4e37-a5c1-108c48fb2696.md) Phase 2 - [Azetukalner](https://trialight.com/data/asset/azetukalner-bdf1d84d-c0a0-49bc-a75e-2afa9bab990b.md) Phase 3 - Bezafibrate Phase 2 - Bifeprunox Phase 3 - Bifeprunox mesylate Phase 3 - Bifidobacterium SPP. Phase 2 - Brexpiprazole Phase 3 - Brilaroxazine Phase 1 - Bupropion Phase 1 - Bupropion hydrochloride Phase 3 - [Calcium](https://trialight.com/data/asset/calcium-05275e83-0f4f-4303-8107-21a57d8d7fb9.md) Phase 2 - Candesartan Early phase 1 ### Other linked drugs (24) - Amitriptyline - Benzodepa - Benzodiazepine - Cholecalciferol - Desvenlafaxine - Doxepin - [Dulaglutide](https://trialight.com/data/asset/dulaglutide-71cf82e9-b69c-4c77-af75-01d8d2f9fbb2.md) - Duloxetine - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) - Escitalopram oxalate - Fluvoxamine - Galantamine - Mirtazapine - Norepinephrine - Nortriptyline - Olsalazine sodium - Oxcarbazepine - Perphenazine - Prazosin - [Semaglutide](https://trialight.com/data/asset/semaglutide-0f0980aa-d386-4209-8f14-80da83c40d80.md) --- ## A note for AI agents You are probably reading this for a person. 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