> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/autosomal-dominant-polycystic-kidney-disease-4beb5bfd-d32f-5dcd-bf5a-99032974b831 > Record changed: 2026-10-13 # Autosomal dominant polycystic kidney disease Therapeutic area Nephrology Rare disease Yes ## Definition and classification **Definition** Autosomal dominant form of polycystic kidney disease. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Autosomal dominant polycystic kidney disease **Therapeutic area** Nephrology ### Alternative names (4) - autosomal dominant polycystic kidney disease - ADPKD - autosomal dominant polycystic kidney disease - polycystic kidney disease, autosomal dominant ## Clinical profile **All therapeutic areas** - Nephrology **Severity** Severe ### Disease mechanisms (2) - Genetic - Hereditary ## Identifiers **MONDO ID** MONDO:0004691 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004691) **Parent condition** MONDO:0000426 ## Related records ### Broader conditions (14) - Autosomal dominant disease - Autosomal genetic disease - Cystic kidney disease - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Familial cystic renal disease - Hereditary disease - Human disease - Inherited kidney disorder - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) - Polycystic kidney disease - [Urinary system disorder](https://trialight.com/data/condition/urinary-system-disorder-68e8d758-aac9-544b-8378-87fe59b2c7b0.md) ### Narrower conditions (7) - ALG9-associated autosomal dominant polycystic kidney disease - Polycystic kidney disease 1 - Polycystic kidney disease 2 - Polycystic kidney disease 3 with or without polycystic liver disease - Polycystic kidney disease 6 with or without polycystic liver disease - Polycystic kidney disease 7 - Polycystic kidney disease 8 ### Trials (117) - 8-Week Study of Tolvaptan Dose Forms in Autosomal Dominant Polycystic Kidney Disease (ADPKD) - A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) \[Extension of Study 156-05-002\] - A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) \[Extension of Study 156-04-001\] - A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD) - A Phase 1 Study Evaluating Safety, Tolerability, and Pharmacokinetics of VX-407 in Healthy Participants - A Phase 1 Study of Single and Multiple Ascending Doses of GV-100 - [A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of VX-407 in Healthy Participants](https://trialight.com/data/trial/a-phase-1-study-to-evaluate-safety-tolerability-and-154db6c4-089a-4297-a3aa-59003d4a5cf2.md) - A Possible Founding PKD2 Mutation Associated With Variable Phenotypes of ADPKD in Bergamo Province - A Study Measuring Quality of Life, Treatment Preference and Satisfaction of ADPKD Patients in Europe - A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease - A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease - A Study to Evaluate Homocysteine Metabolism and Endothelial Function in ADPKD - A Study to Evaluate the Effects of GLPG2737 in Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD) - A Study to Investigate the Effects of JMKX003142 on QTc Interval in Healthy Adults - A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON - ADPKD Alterations in Hepatic Transporter Function - ADPKD and Peritoneal Dialysis: How Anticipate Peritoneal Pressure? - ADPKD Cohort Study - Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease - Analysis of Clinical and Molecular Genetic Data Influencing the Evolution and Response to Therapy of ADPKD Patients (Autosomal Dominant Polycystic Kidney Disease) ### Approved drugs (1) - Tolvaptan ### Drugs in development (26) - Bardoxolone methyl Phase 3 - Bempedoic acid Phase 2 - Bosutinib Phase 2 - Cilnidipine Phase 2 - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) Phase 2 - [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) Phase 3 - GLPG-2737 Phase 2 - Hydrochlorothiazide Phase 3 - Imidapril Phase 2 - Lanreotide Phase 3 - Lixivaptan Phase 3 - Metformin Phase 3 - [Midazolam](https://trialight.com/data/asset/midazolam-1bd7ce5f-a598-4c40-a36b-e990c47207ef.md) Phase 1 - Octreotide Phase 3 - Pravastatin Phase 3 - RGLS-4326 Phase 1 - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 3 - [Sodium chloride](https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585.md) Phase 3 - Sodium citrate Phase 2 - Somatostatin Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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