> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/aortic-valve-stenosis-d3f1a482-d908-5993-8a6c-7daad057bb89 > Record changed: 2026-10-13 # Aortic valve stenosis Therapeutic area Cardiology Rare disease No ## Definition and classification **Definition** Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. Individuals with severe cases may faint without warning. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Aortic valve stenosis **Therapeutic area** Cardiology ### Alternative names (6) - aortic valve stenosis - AS - aortic stenosis - rheumatic aortic stenosis - rheumatic aortic valve stenosis - valvular aortic stenosis ## Clinical profile **Disease mechanisms** - Developmental **Severity** Moderate ### All therapeutic areas (2) - Cardiology - Vascular Medicine ## Identifiers **MONDO ID** MONDO:0042981 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0042981) **Parent condition** MONDO:0003803 ## Related records ### Broader conditions (13) - Aortic disorder - Aortic valve disorder - Arterial disorder - Cardiac ventricle disorder - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disorder of development or morphogenesis - Heart disorder - Heart valve disorder - Human disease - Vascular disorder ### Narrower conditions (7) - Aortic valve atresia - Aortic valve dysplasia - Childhood aortic valve stenosis - Congenital aortic valve stenosis - Discrete subaortic stenosis - Subvalvular aortic stenosis - Supravalvular aortic stenosis ### Trials (977) - 10-year Follow-up After Aortic Valve Replacement Surgery - 18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes - 18F-NaF Uptake and Aortic Stenosis Progression - 4 Cities for Assessing CAlcification PRognostic Impact After TAVI - 4D- Flow- MRI After Aortic Valve Surgery - 5 Year Observation of Patients With PORTICO Valves - A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease - A Clinical Evaluation of the HYDRA Self Expanding Transcatheter Aortic Valve - A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis - A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System - A Clinical Trial of the Transcatheter Aortic Valve Implantation System With a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients With Severe Aortic Stenosis - A Clinical Trial of Transcatheter Aortic Valves in Dialysis Patients (Japan) - A Comparison of Advanced Imaging Techniques in Aortic Stenosis - A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial - [A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis](https://trialight.com/data/trial/a-multicenter-trial-assessing-the-impact-of-lipoprotein-a-51773799-ce02-463c-ae31-aa417295a17d.md) - A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delaying the Progression of Calcified Aortic Valve Disease - A Pilot Study to Evaluate the Safety and Efficacy of the Apica Access, Stabilization and Closure (ASC™) Device - A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement - A Prospective Study of Fractional Flow Reserve Assessment of Intermediate Coronary Stenoses in Severe Aortic Stenosis - A Prospective, Multi-centre, Single Arm, Pivotal Clinical Study to Determine the Safety and Effectiveness of Crea Aortic Valve for Use as a Replacement Aortic Heart Valve ### Drugs in development (27) - Alendronic acid Phase 2 - [Apixaban](https://trialight.com/data/asset/apixaban-9e91f03a-6eac-4da8-9f08-88d740399be5.md) Phase 3 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - Aspirin DL-lysine Phase 3 - [Ataciguat](https://trialight.com/data/asset/ataciguat-574a94b9-5b3b-41fb-9593-d8e6b1ad00f2.md) Phase 2 - Bivalirudin Phase 3 - Candesartan Phase 3 - Clopidogrel Phase 3 - [Denosumab](https://trialight.com/data/asset/denosumab-9ee8731d-42aa-4d04-abbd-9dffa084523f.md) Phase 2 - Dihydralazine Phase 3 - Edoxaban Phase 3 - Ezetimibe Phase 3 - Fluvastatin Phase 2 - Heparin Phase 3 - Icosapent ethyl Phase 2 - Metoprolol succinate Phase 2 - Niacin Early phase 1 - Pelacarsen Phase 2 - [Potassium chloride](https://trialight.com/data/asset/potassium-chloride-e069c577-a260-48f9-bde9-bdc7a3fbbad5.md) Phase 2 - Potassium nitrate Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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