> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-a59f9899-4e99-54af-98e3-b03dbdb0192e > Record changed: 2026-10-13 # Anti-neutrophil cytoplasmic antibody-associated vasculitis Therapeutic area Vascular Medicine Rare disease Yes ## Definition and classification **Definition** Group of systemic vasculitis with a strong association with anca. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Anti-neutrophil cytoplasmic antibody-associated vasculitis **Therapeutic area** Vascular Medicine ### Alternative names (4) - anti-neutrophil cytoplasmic antibody-associated vasculitis - AAV - ANCA-associated vasculitis - antineutrophil cytoplasmic antibody-associated vasculitis ## Clinical profile **Disease mechanisms** - Inflammatory **Severity** Severe ### All therapeutic areas (2) - Cardiology - Vascular Medicine ## Identifiers **MONDO ID** MONDO:0015492 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0015492) **Parent condition** MONDO:0800113 ## Related records ### Broader conditions (9) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - Inflammatory disease - Necrotizing vasculitis - Vascular disorder - Vasculitis ### Narrower conditions (3) - Eosinophilic granulomatosis with polyangiitis - Granulomatosis with polyangiitis - Microscopic polyangiitis ### Trials (153) - (68)Ga-FAPI PET/CT in Patients With ANCA-associated Vasculitis - A Clinical Study Evaluating the Safety and Efficacy of GT719 Universal Cell Injection in the Treatment of Immune-mediated Kidney Diseases - A Clinical Study of YTS109 Cell for R/R Autoimmune Diseases - A Clinical Study of YTS109 Cell in R/R Autoimmune Diseases - A Clinical Study of YTS109 Cells for the Treatment of R/R Autoimmune Diseases - [A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease](https://trialight.com/data/trial/a-phase-1-study-of-ft819-in-b-cell-mediated-autoimmune-6b8b0d2c-15f0-4af3-a304-bbce1760f628.md) - [A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease](https://trialight.com/data/trial/a-phase-1-study-of-prulacabtagene-leucel-prula-cel-formerly-0aebce17-d67c-419f-b24a-9fff94392a5e.md) - A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2) - A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis - A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications - A Study in Healthy Volunteers to Evaluate the Pharmacokinetic Food Effect and Cardiac Safety of CCX168 - A Study of Anti-CD19/BCMA Universal CAR-T Cell Therapy RD06-05 in Patients With Autoimmune Diseases. - A Study of CCX168 in Japanese and Caucasian Healthy Adult Males - A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases - A Study of LCAR-AIO in Subjects With Relapsed/Refractory Autoimmune Diseases - A Study of OL-108 in Relapsed/Refractory Autoimmune Diseases - A Study of RD06-04 in Patients With Active Autoimmune Diseases - A Study to Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants - A Study to Assess the Mass Balance Recovery (Absorption, Distribution, Metabolism and Excretion) of \[14C\]CCX168 in Healthy Participants - A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis ### Approved drugs (1) - Avacopan ### Drugs in development (4) - Ruxoprubart Phase 2 - Tarperprumig Phase 2 - [Tominersen](https://trialight.com/data/asset/tominersen-ad27b249-1f74-46e0-90f9-4c17f452879d.md) Phase 1 - Vilobelimab Phase 1 ### Other linked drugs (1) - Lornoxicam --- ## A note for AI agents You are probably reading this for a person. 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