> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/angioosteohypertrophic-syndrome-b1985d76-4d10-53c5-a7ee-9795ffea0afa
> Record changed: 2026-10-13

# Angioosteohypertrophic syndrome

Therapeutic area

Vascular Medicine

Rare disease

Yes

## Definition and classification

**Definition**

A congenital vascular bone syndrome (CVBS) characterized by the presence of a vascular malformation in a limb, mainly of the arteriovenous type, which results in overgrowth of the affected limb.

**Genetic basis**

Yes

**Non-human condition**

No

**Rare disease**

Yes

**Listing at source**

Listed

**Condition name**

Angioosteohypertrophic syndrome

**Therapeutic area**

Vascular Medicine

### Alternative names (13)

- angioosteohypertrophic syndrome
- Klippel Trenaunay syndrome
- Klippel-Trenaunay Syndrome
- Klippel-Trenaunay syndrome
- Klippel-Trenaunay-Weber syndrome
- Klippel-Trenaunay-Weber syndrome, Isolated cases
- Klippel-Trénaunay syndrome
- Klippel-Trénaunay-Weber syndrome
- Weber-Klippel-Trenaunay
- angioosteohypertrophy syndrome
- haemangiectatic hypertrophy
- KTS
- angio-osteohypertrophy syndrome

## Clinical profile

**Severity**

Severe

### Disease mechanisms (4)

- Developmental
- Genetic
- Hereditary
- Syndromic

### All therapeutic areas (2)

- Cardiology
- Vascular Medicine

## Identifiers

**MONDO ID**

MONDO:0007864

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007864)

**Parent condition**

MONDO:0002254

## Related records

### Broader conditions (13)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md)
- Developmental defect during embryogenesis
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Disorder of development or morphogenesis
- Hereditary disease
- Human disease
- Overgrowth syndrome
- Syndromic disease
- Vascular disorder

### Trials (9)

- [A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)](https://trialight.com/data/trial/a-phase-2-study-of-mutant-selective-pi3k-inhibitor-rly-2608-cb48d7d4-b39e-48fc-b89b-e54745cb8b7c.md)
- A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome
- Clinical and Paraclinical Characterization of Osseous Anomalies of the Long Bones of Patients With Klippel Trénaunay Syndrome
- French National Cohort of Children With Port Wine Stain
- Identification of Biomarkers for Patients with Vascular Anomalies
- Lymphatic Anomalies Registry for the Assessment of Outcome Data
- National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)
- Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the Periphery
- Vascular Anomaly Pathology and Genomics Biopsy Study

### Other linked drugs (1)

- [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md)

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