> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/androgen-insensitivity-syndrome-5e78fd1b-fff3-518c-96a5-f52b0664927e > Record changed: 2026-10-13 # Androgen insensitivity syndrome Therapeutic area Endocrinology Rare disease Yes ## Definition and classification **Definition** Androgen insensitivity syndrome (AIS) is a disorder of sex development (DSD) characterized by the presence of female external genitalia, ambiguous genitalia or variable defects in virilization in a 46,XY individual with absent or partial responsiveness to age-appropriate levels of androgens. It comprises two clinical subgroups: complete AIS (CAIS) and partial AIS (PAIS). **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Androgen insensitivity syndrome **Therapeutic area** Endocrinology ### Alternative names (9) - androgen insensitivity syndrome - AIS - Goldberg-Maxwell syndrome - Morris syndrome - androgen insensitivity syndrome - androgen insensitivity, X-linked recessive - androgen resistance syndrome - testicular feminization syndrome - testicular feminization syndrome (formerly) ## Clinical profile **Severity** Severe ### Disease mechanisms (3) - Developmental - Genetic - Hereditary ### All therapeutic areas (2) - Endocrinology - Reproductive Health ## Identifiers **MONDO ID** MONDO:0019154 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019154) **Parent condition** MONDO:0003847 ## Related records ### Broader conditions (14) - 46 XY differences of sex development - Developmental defect during embryogenesis - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Disorder of development or morphogenesis - Disorder of sexual differentiation - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - Gonadal disorder - Hereditary disease - Human disease - Reproductive system disorder ### Narrower conditions (2) - Complete androgen insensitivity syndrome - Partial androgen insensitivity syndrome ### Trials (27) - A Multicentre, Randomised, Double-blind, Placebo-parallel Controlled Phase Ⅲ Clinical Trial Evaluating the Efficacy and Safety of BXOS110 Injection in the Treatment of Acute Ischaemic Stroke Within 3 Hours of Onset. - A Phase I Trial of Umbilical Cord Mesenchymal Stromal Cells for Acute Ischemic Stroke - [A Phase Ⅲ Study to Evaluate the Efficacy, Immunogenicity, Safety of Quadrivalent HPV Recombinant Vaccine in Chinese Healthy Females](https://trialight.com/data/trial/a-phase-iii-study-to-evaluate-the-efficacy-immunogenicity-5428ea99-be6b-4e66-9faa-9ad750a3bf50.md) - A Prospective, Multi-center and Randomized Controlled Trial of Tianyi Revascularization Device in Acute Ischemic Stroke - A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy - Acute Training Effect Assessment in Adolescent Idiopathic Scoliosis - Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity - Cervical Alignment Changes After Correction of Thoracic Adolescent Idiopathic Scoliosis With Thoracic Hypokyphosis - Disorders of Sexual Development and Gonadal Tumor Risk - Endovascular Treatment for Acute Large Vessel Occlusion With Ultra-Large Ischemic Core - Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females - Evaluate the Immunogenicity and Safety of 4-valent and 9-valent HPV Recombinant Vaccine in Chinese Healthy Females - Evaluate the Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females - Evaluate the Safety and Primary Immunogenicity of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females - Evaluation of Mechanical Thrombectomy in Acute Ischemic Stroke Related to a Distal Arterial Occlusion - Evaluation of the AIIS Using Hip Ultrasound(AIISUS) - FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions - Growing up With the Young Endocrine Support System (YESS!) - Immunobridging Study of 9-valent Human Papillomavirus Recombinant Vaccine in Chinese Females Aged 9 to 19 Years - Investigating the Potential Psychological Impact of Early Screening and Long-term Monitoring for Adolescent Idiopathic Scoliosis Among Patients and Caregivers --- ## A note for AI agents You are probably reading this for a person. 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