Androgen insensitivity syndrome
Therapeutic area
Endocrinology
Rare disease
Yes
- Definition
- Androgen insensitivity syndrome (AIS) is a disorder of sex development (DSD) characterized by the presence of female external genitalia, ambiguous genitalia or variable defects in virilization in a 46,XY individual with absent or partial responsiveness to age-appropriate levels of androgens. It comprises two clinical subgroups: complete AIS (CAIS) and partial AIS (PAIS).
- Genetic basis
- Yes
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Androgen insensitivity syndrome
- Therapeutic area
- Endocrinology
- androgen insensitivity syndrome
- AIS
- Goldberg-Maxwell syndrome
- Morris syndrome
- androgen insensitivity syndrome
- androgen insensitivity, X-linked recessive
- androgen resistance syndrome
- testicular feminization syndrome
- testicular feminization syndrome (formerly)
- Severity
- Severe
- Developmental
- Genetic
- Hereditary
- Endocrinology
- Reproductive Health
- MONDO ID
- MONDO:0019154
- Parent condition
- MONDO:0003847
Related records
Broader conditions (14)
- 46 XY differences of sex development
- Developmental defect during embryogenesis
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Disorder of development or morphogenesis
- Disorder of sexual differentiation
- Endocrine system disorder
- Gonadal disorder
- Hereditary disease
- Human disease
- Reproductive system disorder
Narrower conditions (2)
- Complete androgen insensitivity syndrome
- Partial androgen insensitivity syndrome
Trials (27)
- A Multicentre, Randomised, Double-blind, Placebo-parallel Controlled Phase Ⅲ Clinical Trial Evaluating the Efficacy and Safety of BXOS110 Injection in the Treatment of Acute Ischaemic Stroke Within 3 Hours of Onset.
- A Phase I Trial of Umbilical Cord Mesenchymal Stromal Cells for Acute Ischemic Stroke
- A Phase Ⅲ Study to Evaluate the Efficacy, Immunogenicity, Safety of Quadrivalent HPV Recombinant Vaccine in Chinese Healthy Females
- A Prospective, Multi-center and Randomized Controlled Trial of Tianyi Revascularization Device in Acute Ischemic Stroke
- A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy
- Acute Training Effect Assessment in Adolescent Idiopathic Scoliosis
- Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity
- Cervical Alignment Changes After Correction of Thoracic Adolescent Idiopathic Scoliosis With Thoracic Hypokyphosis
- Disorders of Sexual Development and Gonadal Tumor Risk
- Endovascular Treatment for Acute Large Vessel Occlusion With Ultra-Large Ischemic Core
- Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females
- Evaluate the Immunogenicity and Safety of 4-valent and 9-valent HPV Recombinant Vaccine in Chinese Healthy Females
- Evaluate the Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females
- Evaluate the Safety and Primary Immunogenicity of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females
- Evaluation of Mechanical Thrombectomy in Acute Ischemic Stroke Related to a Distal Arterial Occlusion
- Evaluation of the AIIS Using Hip Ultrasound(AIISUS)
- FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions
- Growing up With the Young Endocrine Support System (YESS!)
- Immunobridging Study of 9-valent Human Papillomavirus Recombinant Vaccine in Chinese Females Aged 9 to 19 Years
- Investigating the Potential Psychological Impact of Early Screening and Long-term Monitoring for Adolescent Idiopathic Scoliosis Among Patients and Caregivers