> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59 > Record changed: 2026-10-13 # Amyotrophic lateral sclerosis Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Amyotrophic lateral sclerosis **Therapeutic area** Neurology ### Alternative names (5) - amyotrophic lateral sclerosis - ALS - Charcot disease - Lou Gehrig disease - amyotrophic lateral sclerosis ## Clinical profile **All therapeutic areas** - Neurology **Severity** Terminal ## Identifiers **MONDO ID** MONDO:0004976 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004976) **Parent condition** MONDO:0003182 ## Related records ### Broader conditions (10) - Anterior horn disorder - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Human disease - Motor neuron disorder - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) - Neuromuscular disease - Spinal cord disorder ### Narrower conditions (38) - Adult progressive spinal muscular atrophy, Aran Duchenne type - Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia - Amyotrophic lateral sclerosis 27, juvenile - Amyotrophic lateral sclerosis 28 - Amyotrophic lateral sclerosis type 1 - Amyotrophic lateral sclerosis type 10 - Amyotrophic lateral sclerosis type 11 - Amyotrophic lateral sclerosis type 12 - Amyotrophic lateral sclerosis type 15 - Amyotrophic lateral sclerosis type 16 - Amyotrophic lateral sclerosis type 18 - Amyotrophic lateral sclerosis type 19 - Amyotrophic lateral sclerosis type 2, juvenile - Amyotrophic lateral sclerosis type 20 - Amyotrophic lateral sclerosis type 21 - Amyotrophic lateral sclerosis type 22 - Amyotrophic lateral sclerosis type 23 - Amyotrophic lateral sclerosis type 3 - Amyotrophic lateral sclerosis type 4 - Amyotrophic lateral sclerosis type 5 ### Trials (1,009) - "New Perspectives of Adaptation to NIV in ALS" - \[18F\]ACI-19626 PET in TDP-43 Proteinopathies - \[BrainConnexion\] - Neurodevice Phase I Trial - 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS) - 3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS) - A 12-week, Multicenter, Safety and Dose-ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosis - A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis - A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS) - A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery - A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients - A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) - A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS) - A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS) - A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis. - A Clinical Trial to Evaluate the Safety and Efficacy of Fycompa in Subjects With Amyotrophic Lateral Sclerosis (ALS) - A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS) - A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS) - A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis - A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS - A First in Human Study of ORT247 in Healthy Volunteers ### Approved drugs (3) - Edaravone - Riluzole - Tofersen ### Drugs in development (147) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 1 - Acetylcarnitine Phase 2 - Acetylcysteine zidrimer Phase 1 - [Albumin human](https://trialight.com/data/asset/albumin-human-95414b67-0d38-49d4-91b2-27b1c6c17389.md) Phase 2 - Aldesleukin Phase 2 - Amantadine hydrochloride Phase 2 - [Ambroxol](https://trialight.com/data/asset/ambroxol-bc0c5848-603d-4f8a-bc12-a4bba0b74621.md) Phase 2 - [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) Phase 2 - ANX-005 Phase 2 - ARGX-119 Phase 2 - Arimoclomol Phase 3 - Arundic acid Phase 2 - Atropine Phase 2 - Atsm copper (II) Phase 2 - Basiliximab Phase 2 - Biotin Phase 2 - Bosutinib Phase 1 - Caffeine Phase 1 - Cannabidiol Phase 3 - Cannabinol Phase 2 ### Other linked drugs (5) - Arhalofenate - Evetifator - Nerve growth factor - Psilocybin - Tofacitinib --- ## A note for AI agents You are probably reading this for a person. 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