> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488 > Record changed: 2026-10-13 # Alzheimer disease Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Alzheimer disease **Therapeutic area** Neurology ### Alternative names (9) - Alzheimer disease - AD - Alzheimer dementia - Alzheimer disease - Alzheimer's dementia - Alzheimer's disease - Alzheimers disease - presenile and senile dementia - Alzheimer disease, familial ## Clinical profile **All therapeutic areas** - Neurology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0004975 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004975) **Parent condition** MONDO:0001627 ## Related records ### Broader conditions (12) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Cognitive disorder - [Dementia](https://trialight.com/data/condition/dementia-c61efc95-c071-50d2-9df7-acb34b2a720c.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by molecular mechanism - Human disease - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) - Psychiatric disorder - Tauopathy ### Narrower conditions (21) - Alzheimer disease 10 - Alzheimer disease 11 - Alzheimer disease 12 - Alzheimer disease 13 - Alzheimer disease 14 - Alzheimer disease 16 - Alzheimer disease 17 - Alzheimer disease 18 - Alzheimer disease 19 - Alzheimer disease 2 - Alzheimer disease 3 - Alzheimer disease 4 - Alzheimer disease 5 - Alzheimer disease 6 - Alzheimer disease 7 - Alzheimer disease 8 - Alzheimer disease type 1 - Alzheimer disease without neurofibrillary tangles - Alzheimer disease, familial early-onset, with coexisting amyloid and prion pathology - Early-onset autosomal dominant Alzheimer disease ### Trials (3,892) - " The Eyes Have it " : Ocular Saccade Abnormalities in Prodromal Alzheimer's Disease - "Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program" - "Safety in Dementia": An Online Caregiver Intervention - \[11C\]MK-6884 Positron Emission Tomography (PET) Tracer Validation Trial (MK-6884-001) - \[18F\]-MFBG Versus \[123I\]-MIBG and \[18F\]-PE2I in PD vs. MSA and DLB vs. AD - \[18F\]ACI-19626 PET in TDP-43 Proteinopathies - \[18F\]APN-1607 PET in Subjects With AD Compared to HC - \[18F\]AV45(Aβ) and \[18F\]AV1451(Tau)PET/CT in the Diagnosis of Early Pathological Changes of Alzheimer's Disease - \[18F\]F-AraG PET Imaging in Alzheimer's Disease - \[18F\]Florbetazine (\[18F\]92) for Beta Amyloid PET Imaging in Alzheimer's Disease - \[18F\]FT8 PET Imaging in Immunoglobulin Light Chain Amyloidosis - \[18F\]MC225-PET in Neurodegenerative Disease - \[18F\]MK-3328 as a Possible Novel Positron Emission Tomography (PET) Tracer for the Detection of Brain Amyloid Plaques (MK-3328-002) - \[18F\]MK-6240 Positron Emission Tomography (PET) Tracer First-in-Human Validation Study (MK-6240-001) - \[18F\]NIDF PET Imaging in Tau-related Diseases - \[18F\]PI-2620 Phase 3 Histopathological Study - \[18F\]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Disease and Other Neurodegenerative Disease - 10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology - 11C-PIB PET Study in MESA at Columbia University - 12-Month Open-Label Extension Study of Intepirdine (RVT-101) in Subjects With Alzheimer's Disease: MINDSET Extension ### Approved drugs (13) - [Aducanumab](https://trialight.com/data/asset/aducanumab-d7f09a77-3bba-47ee-b5c6-b358810893be.md) - [Donanemab](https://trialight.com/data/asset/donanemab-05021786-bb73-4502-9e7d-3cbd9f71b58f.md) - Donepezil hydrochloride - Florbetaben F18 - Florbetapir F 18 - Flortaucipir F 18 - Flutemetamol F 18 - Galantamine hydrobromide - Ioflupane I 123 - [Lecanemab](https://trialight.com/data/asset/lecanemab-49c04892-5218-40d4-bf54-c66ea2ad6d64.md) - Memantine hydrochloride - Rivastigmine - Rivastigmine tartrate ### Drugs in development (344) - 2-hydroxypropyl-beta-cyclodextrin Phase 2 - 2,4-dinitrophenol Phase 2 - ABT-126 Phase 2 - ABT-288 Phase 2 - ABT-384 Phase 2 - Acetylcysteine Early phase 1 - Acitretin Phase 2 - Adenosine triphosphate Phase 2 - Alanine Early phase 1 - [Albumin human](https://trialight.com/data/asset/albumin-human-95414b67-0d38-49d4-91b2-27b1c6c17389.md) Phase 3 - Aldesleukin Phase 2 - Aleplasinin Phase 1 - Amilomotide Phase 2 - APP-311 Phase 2 - AQW051 Phase 2 - Arginine Phase 2 - [Aripiprazole](https://trialight.com/data/asset/aripiprazole-ca9997bd-e762-4bd5-ae57-3df4e68a30dd.md) Phase 3 - Arundic acid Phase 2 - [Atabecestat](https://trialight.com/data/asset/atabecestat-5f27c9d3-bd39-4d17-ae59-5b1150d56b6d.md) Phase 2 - [Atomoxetine hydrochloride](https://trialight.com/data/asset/atomoxetine-hydrochloride-ec642fa5-6de5-4361-a5d5-ba620d2a4aef.md) Phase 2 ### Other linked drugs (29) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) - Alvameline - Apabetalone - Berotralstat hydrochloride - Bifemelane - BIIB-080 - [Bimatoprost](https://trialight.com/data/asset/bimatoprost-6eef0f4d-2227-4a51-94e0-7508a5f1c01b.md) - [Cinhyaluronate sodium](https://trialight.com/data/asset/cinhyaluronate-sodium-3032be48-a2e5-444e-9aff-f44e2e320737.md) - CX-717 - Ergoloid mesylates - Felcisetrag - Gadolinium - Galcanezumab - [Glycopyrronium bromide](https://trialight.com/data/asset/glycopyrronium-bromide-3e811428-27d6-4276-96b9-b0b17847e0e3.md) - Guanfacine hydrochloride - Latozinemab - Lisdexamfetamine dimesylate - Methylphenidate hydrochloride - Milacemide - MK-2461 --- ## A note for AI agents You are probably reading this for a person. 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