> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/al-amyloidosis-42ae488b-dbd7-50a6-8ec6-a47098470cd8 > Record changed: 2026-11-04 # AL amyloidosis Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** AL amyloidosis **Therapeutic area** Neurology ### Alternative names (19) - AL amyloidosis - AL Amyloidosis (AL) - Light Chain (AL) Amyloidosis - Light Chain (AL) Amyloidosis, Stage 3B - Light Chain Amyloidosis - Light-chain amyloidosis - Newly Diagnosed Primary Amyloidosis - primary amyloidosis - Recurrent AL Amyloidosis - Recurrent Primary Amyloidosis - Refractory AL Amyloidosis - Refractory Primary Amyloidosis - Relapsed AL Amyloidosis - amyloidosis AL - amyloidosis primary systemic - primary AL amyloidosis - primary systemic AL amyloidosis - primary systemic amyloidosis - systemic AL amyloidsis ## Clinical profile **Severity** Severe ### All therapeutic areas (5) - Cardiology - Metabolic Disease - Neurology - Neuromuscular Disease - Rheumatology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019438) ## Identifiers **MONDO ID** MONDO:0019438 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019438) **Parent condition** MONDO:0005071 ## Related records ### Broader conditions (20) - Acquired metabolic disease - [Amyloidosis](https://trialight.com/data/condition/amyloidosis-b8b4cb9d-0eae-5851-8654-8d69fd195e67.md) - [Cardiomyopathy](https://trialight.com/data/condition/cardiomyopathy-f867c8a5-a3a9-513d-a7ca-7e2d05ad56d3.md) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by molecular mechanism - [Heart disorder](https://trialight.com/data/condition/heart-disorder-76f9236b-5b5b-52a4-b1c8-771e427815e6.md) - Human disease - [Hypertrophic cardiomyopathy](https://trialight.com/data/condition/hypertrophic-cardiomyopathy-2bcaf1dc-551c-50d7-8f5b-4b8457815d3c.md) - Intrinsic cardiomyopathy - [Metabolic disease](https://trialight.com/data/condition/metabolic-disease-3d73c19d-b8c8-5be8-add5-77c7d794dacd.md) - Muscle tissue disorder - [Musculoskeletal system disorder](https://trialight.com/data/condition/musculoskeletal-system-disorder-16f6e157-12a0-54ee-9e24-377731f344a5.md) - [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md) - Non-familial hypertrophic cardiomyopathy - Non-familial restrictive cardiomyopathy - Proteostasis deficiencies - Restrictive cardiomyopathy ### Narrower conditions (2) - Primary localized amyloidosis - Primary systemic amyloidosis ### Trials (249) - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 124I-p5+14 Injection Safety in Subjects With Systemic Amyloidosis - 2nd Autologous Stem Cell Transplant in Patients With Persistent/Recurrent (AL) Amyloidosis - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - A Clinical Study of Melphalan Flufenamide (Melflufen) and Dexamethasone for Patients With Immunoglobulin Light Chain (AL) Amyloidosis - A Clinical Study on Minimal Residual Disease in Patients With Systemic Light Chain Amyloidosis - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A EUropean REgistry and Sample Sharing networK to Promote the Diagnosis and Management of Light Chain Amyloidosis (EUREKA) - A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis - A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis. - A Phase I/II Open-label, Single-arm, Multicenter Clinical Study to Evaluate the Safety and Efficacy of FKC289 in Subjects With Relapsed/Refractory Primary AL Amyloidosis - A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects With Previously-Treated AL Amyloidosis - A Phase II Study to Evaluate the Efficacy and Safety of Teclistamab in Combination With Daratumumab (Tec-Dara) in Newly Diagnosed Multiple Myeloma With Concurrent Light Chain Amyloidosis (MM+AL). - A Phase II Trial of Teclistamab in Participants With Previously Treated Immunoglobulin Light-chain (AL) Amyloidosis - A Pilot Study of Anselamimab in Patients With AL Amyloidoma and Measurable Tissue Involvement - A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of NXC-201 Compared With Daratumumab With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) in Newly Diagnosed Systemic AL Amyloidosis - A Registry of AL Amyloidosis (ReAL) - A Registry of Chinese AL Amyloidosis Patients Treated With Subcutaneous or Intravenous Daratumumab ### Approved drugs (2) - Tafamidis - Tafamidis meglumine ### Drugs in development (38) - Amiodarone Phase 2 - Amiodarone hydrochloride Phase 2 - Anselamimab Phase 3 - Belantamab mafodotin Phase 2 - [Bendamustine](https://trialight.com/data/asset/bendamustine-07f7a21f-820a-4423-a534-0d6d0380b382.md) Phase 2 - [Bendamustine hydrochloride](https://trialight.com/data/asset/bendamustine-hydrochloride-96c86887-fb47-429c-8d83-f212e0d0fe0b.md) Phase 2 - Birtamimab Phase 3 - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) Phase 3 - Bortezomib D-mannitol Phase 1 - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) Phase 1 - Coagulation factor X human Phase 3 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) Phase 2 - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) Phase 3 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 3 - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) Phase 2 - Elotuzumab Phase 2 - [Elranatamab](https://trialight.com/data/asset/elranatamab-43094116-a114-45cf-88c8-60ef9865def2.md) Phase 1 - Epigalocatechin gallate Phase 2 - Equecabtagene autoleucel Phase 2 ### Other linked drugs (2) - Antilymphocyte immunoglobulin (horse) - Tacrolimus --- ## A note for AI agents You are probably reading this for a person. 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