> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c > Record changed: 2026-10-13 # Age-related macular degeneration Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Age-related macular degeneration **Therapeutic area** Neurology ### Alternative names (6) - age-related macular degeneration - AMD - ARMD - Senile macular retinal degeneration - age-related macular degeneration - macular degeneration, age-related ## Clinical profile **Severity** Severe ### Disease mechanisms (2) - Genetic - Hereditary ### All therapeutic areas (2) - Neurology - Ophthalmology ## Identifiers **MONDO ID** MONDO:0005150 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005150) **Parent condition** MONDO:0002175 ## Related records ### Broader conditions (16) - Degeneration of macula and posterior pole - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Disorder of orbital region - Disorder of visual system - Eye disorder - Hereditary disease - Hereditary neurological disease - Human disease - Inherited retinal dystrophy - [Macular degeneration](https://trialight.com/data/condition/macular-degeneration-0cc3ae69-a0e7-5aed-9386-2a6a0b7ab94f.md) - Nervous system disorder - Retinal degeneration - Retinal disorder ### Narrower conditions (15) - Age related macular degeneration 1 - Age related macular degeneration 10 - Age related macular degeneration 11 - Age related macular degeneration 12 - Age related macular degeneration 14 - Age related macular degeneration 2 - Age related macular degeneration 4 - Age related macular degeneration 6 - Age related macular degeneration 7 - Age related macular degeneration 8 - Age related macular degeneration 9 - Dry age related macular degeneration - Macular degeneration, age-related, 3 - Macular dystrophy with central cone involvement - [Wet macular degeneration](https://trialight.com/data/condition/wet-macular-degeneration-fce04054-9f5d-5a0b-8ba9-fb08ba7393ba.md) ### Trials (697) - "Stop Early Age-related Macular Degeneration (AMD) From Vision Loss Eternally" Study - 20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD) - 30g vs 33g Needle for Intravitreal Injections - A 16 Week Evaluation of the Novartis Health Management Tool (HMT) in Age Related Macular Degeneration (AMD) - A 24 Month Phase 2a Open Label, Randomized Study of Avastin®, Lucentis®, or Eylea® (Anti-VEGF Therapy) Administered in Combination With Fovista® (Anti-PDGF BB Pegylated Aptamer) - A 3-month Study to Assess the Safety and Effectiveness of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) - A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders - A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders - A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) - A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) - A Clinical Trial Evaluating the Efficacy and Safety of Sanhuang Jingshiming Pills in the Treatment of nAMD - [A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)](https://trialight.com/data/trial/a-clinical-trial-of-eye201-mk-8748-in-people-with-macular-90b89db5-5302-42fb-ba5b-3d3437205ca8.md) - [A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)](https://trialight.com/data/trial/a-clinical-trial-of-eye201-mk-8748-in-people-with-macular-ea138d8e-cfd4-45eb-a9cb-06686d6d126d.md) - A Clinical Trial to Explore Safety and Efficacy of Different Doses of Pegaptanib Sodium, Compared to Sham, in Patients With Wet AMD. - A Clinical Trial to Explore the Safety and Efficacy of Injections of Macugen When Given Every 6 Weeks in Subjects With AMD - A Collaborative Resource of Heidelberg Multimodal Imaging of Intermediate and Early Atrophic AMD Cases to Study Prediction of Disease Progression - A Comparison of Ranibizumab and Aflibercept for the Development of Geographic Atrophy in (Wet) AMD Patients - A Comparison of the Checkup Vision Assessment System to Standard Vision Assessment Tools - A Dose Escalation Trial of an Intravitreal Injection of Sirna-027 in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) - A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration ### Approved drugs (1) - Verteporfin ### Drugs in development (95) - Abicipar pegol Phase 3 - Acetylcysteine Phase 3 - Acyclovir sodium Phase 1 - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) Phase 2 - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Phase 3 - AGN-211745 Phase 2 - AL-78898A Phase 2 - [Alteplase](https://trialight.com/data/asset/alteplase-89461f67-4f40-4a00-ae4c-727752018887.md) Phase 2 - Ammonium trichlorotellurate Phase 1 - Anecortave acetate Phase 3 - Anti-GD2 monoclonal antibody 3F8 Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - Atorvastatin Phase 2 - [Avacincaptad pegol](https://trialight.com/data/asset/avacincaptad-pegol-3eccd839-26a0-429c-b503-e2c946f56787.md) Phase 2 - Avacincaptad pegol sodium Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 3 - Bevasiranib Phase 3 - Brolucizumab Phase 3 - Bromfenac Phase 2 - [Canakinumab](https://trialight.com/data/asset/canakinumab-7cd74b21-082d-4a09-8847-aa6d401bc853.md) Phase 1 ### Other linked drugs (8) - Disitertide - Gildeuretinol - Lampalizumab - Loteprednol etabonate - [Moxifloxacin](https://trialight.com/data/asset/moxifloxacin-17fc41bd-6b29-4dda-a755-554e6ce94ccc.md) - Nesvategrast isobutanolammonium - Omega-3 fatty acids - Retinol --- ## A note for AI agents You are probably reading this for a person. 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