Adenoid cystic carcinoma
Therapeutic area
Oncology
Rare disease
No
- Definition
- A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- No
- Listing at source
- Listed
- Condition name
- Adenoid cystic carcinoma
- Therapeutic area
- Oncology
- adenoid cystic carcinoma
- adenocystic carcinoma
- adenoid cystic cancer
- adenoid cystic carcinoma
- cylindroid adenocarcinoma
- cribriform carcinoma
- cylindroma
- All therapeutic areas
- Oncology
- Severity
- Severe
- MONDO ID
- MONDO:0004971
- Parent condition
- MONDO:0004970
Related records
Broader conditions (11)
- Adenocarcinoma
- Cancer
- Cancer or benign tumor
- Carcinoma
- Disease
- Disease by etiologic mechanism
- Epithelial neoplasm
- Glandular cell neoplasm
- Human disease
- Neoplasm
- Neoplastic disease or syndrome
Narrower conditions (24)
- Adenoid cystic breast carcinoma
- Adenoid cystic carcinoma of oropharynx
- Adenoid cystic carcinoma of the corpus uteri
- Bartholin gland adenoid cystic carcinoma
- Cervical adenoid cystic carcinoma
- Cutaneous adenocystic carcinoma
- Esophageal adenoid cystic carcinoma
- Ethmoid sinus adenoid cystic carcinoma
- Lacrimal gland adenoid cystic carcinoma
- Laryngeal adenoid cystic carcinoma
- Lung adenoid cystic carcinoma
- Lymph node adenoid cystic carcinoma
- Major salivary gland adenoid cystic carcinoma
- Maxillary sinus adenoid cystic carcinoma
- Minor salivary gland adenoid cystic carcinoma
- Paranasal sinus adenoid cystic carcinoma
- Parotid gland adenoid cystic carcinoma
- Pharyngeal adenoid cystic carcinoma
- Prostate adenoid cystic carcinoma
- Salivary gland adenoid cystic carcinoma
Trials (79)
- 177Lu-PSMA (177Lu-PNT2002) in PSMA-Positive Adenoid Cystic Carcinoma
- 68Ga-FAPI PET/CT for the Detection of Adenoid Cystic Carcinoma(ACC)
- 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma
- 9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma
- A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages
- A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers
- A Study Of AL101In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations
- A Study of Apatinib in Recurrent/Metastatic Adenoid Cystic Carcinoma of the Head and Neck
- A Study of Becotatug Vedotin (MRG003) Combined With Epirubicin as Neoadjuvant Therapy for EGFR-Positive, Unresectable Recurrent Sinonasal Adenoid Cystic Carcinoma
- A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors
- A Study of Enfortumab Vedotin in People With Adenoid Cystic Carcinoma
- A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors
- A Study of PRT543 in Participants With Advanced Solid Tumors and Hematologic Malignancies
- A Study of Sunitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands
- A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
- A Study to Evaluate the Efficacy and Safety of Rivoceranib in Participants With Recurrent or Metastatic Adenoid Cystic Carcinoma (ACC)
- A Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic Carcinoma
- Adenoid Cystic Carcinoma and Carbon Ion Only Irradiation
- Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
- Agnostic Therapy in Rare Solid Tumors
Drugs in development (17)
- Avelumab Phase 2
- Axitinib Phase 2
- Cetuximab Phase 1
- Dovitinib Phase 2
- Doxorubicin Phase 2
- Enfortumab vedotin Phase 2
- Everolimus Phase 2
- Lenvatinib Phase 2
- Lutetium LU 177 zadavotide guraxetan Phase 2
- Lutetium LU-177 vipivotide tetraxetan Phase 2
- Osugacestat Phase 2
- Pembrolizumab Phase 2
- Regorafenib Phase 2
- Rivoceranib Phase 2
- Rivoceranib mesylate Phase 2
- Tretinoin Phase 2
- Tucidinostat Phase 2
Other linked drugs (1)
- Brontictuzumab