> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/acute-myeloid-leukemia-with-mutated-npm1-c60196f4-4e4f-5cc9-a94f-40a5eea6cd8e
> Record changed: 2026-10-13

# Acute myeloid leukemia with mutated NPM1

Therapeutic area

Hematology

Rare disease

No

## Definition and classification

**Definition**

An acute myeloid leukemia with mutation of the nucleophosmin gene. It is usually associated with normal karyotype and frequently has myelomonocytic or monocytic features. It usually responds to induction therapy.

**Genetic basis**

No

**Non-human condition**

No

**Rare disease**

No

**Listing at source**

Listed

**Condition name**

Acute myeloid leukemia with mutated NPM1

**Therapeutic area**

Hematology

### Alternative names (11)

- acute myeloid leukemia with mutated NPM1
- AML with mutated NPM1
- AML, Mutation of the Nucleophosmin Gene
- AML, NPM1 Mutation
- AML, NPM1 gene mutation
- AML, Nucleophosmin Gene Mutation
- NPMc+ AML
- acute myeloid leukaemia with cytoplasmic nucleophosmin
- acute myeloid leukemia with cytoplasmic nucleophosmin
- acute myeloid leukemia with mutated NPM1
- acute myeloid leukemia, NPM1 gene mutation

## Clinical profile

**Severity**

Severe

### All therapeutic areas (4)

- Hematology
- Immunology
- Oncology
- Rheumatology

## Identifiers

**MONDO ID**

MONDO:0044923

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0044923)

**Parent condition**

MONDO:0018874

## Related records

### Broader conditions (32)

- Acute disease
- [Acute leukemia](https://trialight.com/data/condition/acute-leukemia-29973a51-6824-5634-b887-713630819eb2.md)
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md)
- Bone cancer
- [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md)
- Bone marrow cancer
- Bone marrow disorder
- Bone marrow neoplasm
- Bone neoplasm
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)
- Cancer or benign tumor
- [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md)
- Connective tissue neoplasm
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md)
- [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md)
- Human disease

### Trials (4)

- [A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML](https://trialight.com/data/trial/a-study-to-investigate-the-safety-and-tolerability-of-3a4970a8-b886-418f-bda5-cb9655741f9c.md)
- Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation
- Oral Arsenic Trioxide for NPM1-mutated AML
- [Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia](https://trialight.com/data/trial/safety-and-tolerability-of-ziftomenib-combinations-in-efd67cbe-6049-4b3f-831e-bee7792f10a1.md)

### Drugs in development (1)

- Arsenic trioxide Phase 2

---

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