> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30 > Record changed: 2026-10-13 # Acute myeloid leukemia Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Acute myeloid leukemia **Therapeutic area** Hematology ### Alternative names (32) - acute myeloid leukemia - AML - AML - acute myeloid leukaemia - AML - acute myeloid leukemia - ANLL - acute Nonlymphocytic leukaemia - acute Nonlymphocytic leukemia - acute granulocytic leukaemia - acute granulocytic leukemia - acute myeloblastic leukemia - acute myelocytic leukaemia - acute myelocytic leukemia - acute myelogenous leukemia - acute myelogenous leukemias - acute myeloid leukaemia (AML) - acute myeloid leukemia - acute myeloid leukemia (AML) - acute myeloid leukemia, somatic - acute nonlymphocytic leukaemia - acute nonlymphocytic leukemia - hematopoeitic - acute Myleogenous leukaemia (AML) - hematopoeitic - acute Myleogenous leukemia (AML) - leukemia, acute myeloid, autosomal dominant, somatic mutation - leukemia, acute myeloid, reduced survival in, somatic - leukemia, acute myeloid, somatic And 7 more, listed on the interactive page. ## Clinical profile **Severity** Severe ### All therapeutic areas (4) - Hematology - Immunology - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0018874 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018874) **Parent condition** MONDO:0004643 ## Related records ### Broader conditions (31) - Acute disease - [Acute leukemia](https://trialight.com/data/condition/acute-leukemia-29973a51-6824-5634-b887-713630819eb2.md) - Bone cancer - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone marrow cancer - Bone marrow disorder - Bone marrow neoplasm - Bone neoplasm - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Immune system cancer ### Narrower conditions (111) - Acute basophilic leukemia - Acute biphenotypic leukemia - Acute erythroid leukemia - Acute leukemia of ambiguous lineage - Acute megakaryoblastic leukemia - Acute megakaryoblastic leukemia in adult - Acute megakaryoblastic leukemia in down syndrome - Acute megakaryoblastic leukemia without down syndrome - Acute monocytic leukemia - Acute myeloblastic leukemia with maturation - Acute myeloblastic leukemia without maturation - Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent - Acute myeloid leukemia and myelodysplastic syndromes related to radiation - Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor - Acute myeloid leukemia by FAB classification - Acute myeloid leukemia with 11q23 abnormalities - Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) - Acute myeloid leukemia with BCR-ABL1 - Acute myeloid leukemia with CBFA2T3-GLIS2 fusion - Acute myeloid leukemia with CEBPA somatic mutations ### Trials (2,602) - "InDACtion" vs "3+7" Induction in AML - (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive - 10-day Decitabine, Fludarabine and 2 Gray TBI as Conditioning Strategy for Poor and Very Poor Risk AML in CR1 - 1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML) - 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II - 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - 2157GCCC:Phase 1 of Calaspargase Pegol-mknl W/ Cytarabine and Idarubicin in Newly Dx AML - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 2321GCCC: CRD3874-SI in Patients With Relapsed/Refractory AML - 3 Anthracyclines, 2 Types of Consolidation With Different ARA-C Doses and Maintenance in Adult Acute Myeloid Leukemia - 5-azacytidine Valproic Acid and ATRA in AML and High Risk MDS - 8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia - 8-Chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia - 90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome - A Bioequivalence Study of (Cytarabine: Daunorubicin) Liposome for Injection - A Biomarker-Directed Phase 2 Trial of Tamibarotene (SY-1425) in Participants With Acute Myeloid Leukemia or Myelodysplastic Syndrome - A Clinical Study of 6MW3211 Monotherapy or Combination Therapy for AML or MDS - A Clinical Study of HY035 Cell Injection in the Treatment of CD7-positive Relapsed or Refractory Hematologic Malignancies - A Clinical Study of SKLB1028 Capsule in the Treatment of Recurrence/Refractory AML Patients ### Approved drugs (16) - [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) - Cytarabine - [Daunorubicin](https://trialight.com/data/asset/daunorubicin-903e3e75-4637-461c-9ca8-608fdf707576.md) - Enasidenib mesylate - Gemtuzumab ozogamicin - Gilteritinib fumarate - Glasdegib maleate - Histamine dihydrochloride - [Idarubicin hydrochloride](https://trialight.com/data/asset/idarubicin-hydrochloride-2d428c9b-e95a-4e2e-a059-ddf75f537db0.md) - Ivosidenib - Melphalan hydrochloride - Midostaurin - Olutasidenib - Quizartinib dihydrochloride - Sargramostim - Tagraxofusp ### Drugs in development (418) - 4SC-203 Phase 1 - 8-chloroadenosine Phase 1 - 9-aminocamptothecin Phase 1 - ABBV-744 Phase 1 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 2 - Acetylcysteine Phase 2 - Aclarubicin Phase 3 - AGS62P1 Phase 1 - AHN-12 Phase 1 - AKN-028 Phase 1 - Aldesleukin Phase 3 - Alemtuzumab Phase 3 - Alisertib Phase 2 - Allopurinol Phase 2 - Alovudine F-18 Phase 2 - Alrizomadlin Phase 1 - Alvocidib Phase 2 - Alvocidib hydrochloride Phase 1 - AMG553 Phase 1 - Amifostine Phase 1 ### Other linked drugs (6) - Dasatinib - Fimepinostat - [Lintuzumab actinium AC-225](https://trialight.com/data/asset/lintuzumab-actinium-ac-225-26da561a-a7c4-4383-b485-7aaf1b7dd5da.md) - Luveltamab tazevibulin - MRX-2843 - Naxtarubicin --- ## A note for AI agents You are probably reading this for a person. 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