> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/acute-lymphoblastic-leukemia-a7f89294-3477-5920-8fe1-8aa51fcd1d63 > Record changed: 2026-11-04 # Acute lymphoblastic leukemia Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Acute lymphoblastic leukemia **Therapeutic area** Hematology ### Alternative names (33) - acute lymphoblastic leukemia - acute lymphoblastic leukaemia (ALL) - acute lymphoblastic leukaemia (disease) - acute lymphoblastic leukemia (ALL) - acute lymphoblastic leukemia (disease) - acute lymphoblastic leukemia/lymphoma - acute lymphocytic leukaemia - Acute Lymphocytic Leukaemia Refractory - acute lymphocytic leukemia - Acute Lymphocytic Leukemia Refractory - acute lymphocytic leukemias - acute lymphogenous leukaemia - acute lymphogenous leukemia - acute lymphoid leukaemia - acute lymphoid leukemia - Acute Lymphoid Leukemia, Disease (disorder) - ALL - ALL - acute lymphocytic leukaemia - ALL - acute lymphocytic leukemia - leukemia, lymphoblastic, malignant - Lymphoblastic Leukaemia - Lymphoblastic Leukemia - Lymphoblastic Leukemia Acute - lymphoblastic leukemia, acute - Lymphoblastic Leukemia, Acute Adult And 8 more, listed on the interactive page. ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Hematology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004967) ## Identifiers **MONDO ID** MONDO:0004967 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004967) **Parent condition** MONDO:0003538 ## Related records ### Broader conditions (20) - Acute disease - Acute leukemia - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) - Lymphoid hemopathy - [Lymphoid leukemia](https://trialight.com/data/condition/lymphoid-leukemia-cfb78df0-6fca-5a14-a697-6a1cb49213fe.md) - Lymphoid neoplasm - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplasm of immature B and T cells - Neoplastic disease or syndrome - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) - Precursor lymphoblastic lymphoma/leukemia ### Narrower conditions (49) - Acute biphenotypic leukemia - Adult acute lymphoblastic leukemia - Aggressive NK-cell leukemia - B acute lymphoblastic leukemia with DUX4 rearrangement - B acute lymphoblastic leukemia with PAX5 P80R mutation - B-cell acute lymphoblastic leukemia - B-cell acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) - B-cell adult acute lymphocytic leukemia - B-cell childhood acute lymphoblastic leukemia - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) - B-cell prolymphocytic leukemia - B-lymphoblastic leukemia with MEF2D rearrangement - B-lymphoblastic leukemia with MYC rearrangement - B-lymphoblastic leukemia with NUTM1 rearrangement - B-lymphoblastic leukemia with PAX5alt - B-lymphoblastic leukemia with TCF3-HLF fusion - B-lymphoblastic leukemia with ZNF384 rearrangement - B-lymphoblastic leukemia/lymphoma MLL rearranged - B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1 - B-lymphoblastic leukemia/lymphoma with IAMP21 ### Trials (289) - A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignancies - A Manualised Post-Traumatic Growth Intervention For People With Hematological Cancers In Greece - A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant - A Multi-center Retrospective Study of INO Treating B-ALL - A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) - A Novel CAR-T Combined Expression of IL-15 in the Treatment of Malignant Hematological Tumors - A Pharmacokinetic and Pharmacodynamic Study of Vincristine in Children With Leukemia - A Phase 1 Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Relapsed/Refractory Leukemias Bearing a Rearrangement of the MLL Gene - A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 3 Study to Evaluate Marqibo® in the Treatment of Subjects ≥ 60 Years Old With Newly Diagnosed ALL - A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following Transplantation - A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL - A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation - A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs - A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors - A Study of Anti-CD19 CAR-T Cell Immunotherapy for Refractory /Relapsed B Cell Malignancies - A Study of Low-Dose Decitabine in Relapsed or Refractory Acute Lymphocytic Leukemia (ALL) - A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia - A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies ### Approved drugs (18) - Asparaginase - Asparaginase erwinia chrysanthemi - Blinatumomab - Calaspargase pegol - Chlorambucil - Clofarabine - Crisantaspase - [Cytarabine](https://trialight.com/data/asset/cytarabine-84421e9a-e58a-4782-8114-dad6f6e6118d.md) - Dasatinib - Dasatinib anhydrous - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) - Inotuzumab ozogamicin - Mercaptopurine - [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md) - Pegaspargase - Plerixafor - Ponatinib hydrochloride - [Rituximab](https://trialight.com/data/asset/rituximab-3fb73477-f618-414e-aa0a-9ccba4d6da3f.md) ### Drugs in development (316) - 9-aminocamptothecin Phase 1 - ABT-751 Phase 1 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 2 - Aclarubicin Phase 3 - Acyclovir sodium Phase 1 - AFM-11 Phase 1 - AHN-12 Phase 1 - Aldesleukin Phase 1 - Alemtuzumab Phase 2 - Alisertib Phase 2 - Alisertib sodium Phase 2 - [Allopurinol](https://trialight.com/data/asset/allopurinol-31075c5e-c121-4498-9ea1-d2c48b7a7267.md) Phase 3 - Alovudine F-18 Early phase 1 - Alvocidib Phase 1 - Alvocidib hydrochloride Phase 1 - AMG-404 Phase 1 - Aminopterin Phase 2 - Aminopterin sodium Phase 2 - Amphotericin B Phase 2 - Amsacrine Phase 2 ### Other linked drugs (5) - Epoetin beta - Ergocalciferol - Metformin hydrochloride - Procarbazine - Voriconazole --- ## A note for AI agents You are probably reading this for a person. 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