> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/zidesamtinib-c96e09e2-7a84-4081-858c-ee6f75376d5a
> Record changed: 2026-10-13

# Zidesamtinib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

**Drug name**

Zidesamtinib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

**Molecular weight**

419.46

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

**Structure (SMILES)**

CCn1ncc2c1-c1cnc(N)c(c1)O\[C@H\](C)c1cc(F)ccc1-c1nn(C)nc1C2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

### Other names (26)

- jideytro
- JIDEYTRO
- nu 0002362
- nu 0002362 006
- nu 0002362 009
- nu 2362 010
- nu 520
- NU-0002362
- NU-0002362-006
- NU-0002362-009
- NU-2362-010
- NU-520
- nuv 520
- NUV-520
- nvl 520
- Nvl-520
- NVL-520
- zidesamtinib
- Zidesamtinib
- Zidesamtinib (NVL-520)
- Zidesamtinib \[INN\]
- Zidesamtinib \[USAN\]
- Zidesamtinib \[WHO-DD\]
- zidesamtinib inn
- zidesamtinib usan

And 1 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2739829-00-4

**ChEMBL ID**

CHEMBL5314497

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

**InChIKey**

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314497)

**PubChem compound IDs**

- 166560233

**FDA ingredient codes (UNII)**

- MX5KQV5XHC

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

zidesamtinib

**Type**

Synthetic organic

**Drug name stem**

\-tinib

### Mechanisms of action (3)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
neurotrophic receptor tyrosine kinase 1

**Gene symbol**  
NTRK1

**Protein identifier**  
P04629

**Affinity units**  
pKi
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
c-ros oncogene 1, receptor tyrosine kinase

**Gene symbol**  
ROS1

**Protein identifier**  
P08922

**Median affinity**

9.15

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
c-ros oncogene 1, receptor tyrosine kinase

**Gene symbol**  
ROS1

**Protein identifier**  
P08922

**Median affinity**

7.3

**Affinity units**  
pKi

### Investigated indications (2)

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1

### Trial references

- NCT05118789  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05118789)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

1

**Polar surface area**

96.67

**Calculated partition coefficient (ALogP)**

3.53

**Calculated partition coefficient (XLogP)**

2.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

1

**Heavy atoms**

31

**Molecular formula**

C22H22FN7O

**Monoisotopic mass**

419.18698651

**Natural product**

No

## National Drug Codes

- 85001-101
- 85001-102

## Evidence counts

**Recorded assays**

59

**Active assays**

4

### Active assay types

- Confirmatory

## Related records

### Trials (2)

- [A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)](https://trialight.com/data/trial/a-study-of-zidesamtinib-nvl-520-in-patients-with-advanced-d578611b-b819-459b-bc93-a79dd7116388.md)
- Expanded Access Program of Zidesamtinib (NVL-520) for Patients With Advanced ROS1+ NSCLC or Other ROS1+ Solid Tumors

### In development for (2)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- Neoplasm Phase 2

---

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