> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/zidebactam-bc9ebd02-fe77-4ed2-a18c-ab2f3723af7b > Record changed: 2026-11-04 # Zidebactam Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) **Drug name** Zidebactam Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) **Molecular weight** 391.41 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) **Structure (SMILES)** O=C(NNC(=O)\[C@@H\]1CC\[C@@H\]2CN1C(=O)N2OS(=O)(=O)O)\[C@@H\]1CCCNC1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) ### Other names (20) - ertapenam zidebactam - Ertapenam-Zidebactam - wck 5107 - WCK 5107 - wck 5107 1000 - WCK 5107 1000 - wck 5107 250 mg to 2000 mg - WCK 5107 250 mg to 2000 mg - WCK-5107 - wck5107 - WCK5107 - zidebactam - Zidebactam - zidebactam \[INN\] - ZIDEBACTAM \[USAN\] - Zidebactam \[WHO-DD\] - zidebactam inn - zidebactam usan - zidebactam who dd - Zidebactam, (-)- ## Identifiers **CAS registry numbers** - 1436861-97-0 **ChEMBL ID** CHEMBL4533605 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) **InChIKey** YCZPXRQPDCXTIO-BBBLOLIVSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4533605) **PubChem compound IDs** - 77846445 **RxNorm IDs (RxCUI)** - 2744813 **FDA ingredient codes (UNII)** - YPM97423DB ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** zidebactam **Type** Synthetic organic **Drug name stem** \-bactam **Approval recorded by Guide to Pharmacology** Yes ### Investigated indications - **Condition** Bacterial Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000771 **Subject identifier** D001424 ### Open Targets indications (3) - **Condition identifier** EFO\_0000771 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0003529 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100338 **Highest recorded phase** 3 ### Trial references - NCT05645757 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05645757) ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 4 **Polar surface area** 157.38 **Calculated partition coefficient (ALogP)** \-1.86 **Calculated partition coefficient (XLogP)** \-4.2 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 26 **Molecular formula** C13H21N5O7S **Monoisotopic mass** 391.11616920 **Natural product** Yes ## Evidence counts **Recorded assays** 291 **Active assays** 6 ### Active assay types - Confirmatory ## Related records ### Trials (6) - A Single-center, Open-label, Study Evaluating Safety and Pharmacokinetics of Single Doses of Zidebactam-Cefepime and Metronidazole Alone or in Combination. - MAD Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Intravenous Zidebactam in Healthy Adults - Safety Study of Intravenous Ertapenem in Combination With Zidebactam (WCK 6777) - Study of Cefepime-zidebactam (FEP-ZID) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) - Study of the Metabolism and Excretion of Zidebactam (WCK 5107) Following a Single Intravenous Infusion. - [This is a Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ertapenem-zidebactam Versus Ceftazidime-Avibactam in the Treatment of Hospitalized Adult Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis](https://trialight.com/data/trial/this-is-a-phase-2-study-to-evaluate-the-efficacy-safety-and-5da5bf33-d1fe-499a-a5d9-2af5da432a63.md) ### In development for (3) - [Acute pyelonephritis](https://trialight.com/data/condition/acute-pyelonephritis-83bd05de-bc8b-595e-ba5a-ab06709e6b77.md) Phase 3 - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) Phase 1 - [Urinary tract infection](https://trialight.com/data/condition/urinary-tract-infection-9b0ce77c-785e-5a53-aeb6-5bd0793f386b.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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