ZED-1227
Highest phase reached
Phase 2
Drug type
Small molecule
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Small molecule
- Drug name
- ZED-1227
- Molecular weight
- 528.61
- Structure (SMILES)
- CCC(CC)CNC(=O)Cn1cccc(NC(=O)[C@H](CC/C=C/C(=O)OC)NC(=O)c2cncn2C)c1=O
- tak 227
- Tak-227
- TAK-227
- vilagletistat
- Vilagletistat
- vilagletistat [INN]
- vilagletistat inn
- zed 1227
- Zed-1227
- zed1227
- ZED1227
- CAS registry numbers
- 1542132-88-6
- ChEMBL ID
- CHEMBL4081588
- InChIKey
- VHGWUSABWIEXKQ-BEBFYNPSSA-N
- PubChem compound IDs
- 72950407
- FDA ingredient codes (UNII)
- T4SR539YKF
- First in class
- No
- Orphan designation
- No
- Pharmacology name
- vilagletistat
- Type
- Synthetic organic
- Action type
- Inhibitor
- Target
- transglutaminase 2
- Gene symbol
- transglutaminase 2
- Action
- Inhibition
- Action type
- Inhibitor
- Target
- transglutaminase 2
- Gene symbol
- TGM2
- Protein identifier
- P21980
- Median affinity
- 7.28
- Affinity units
- pIC50
- Condition identifier
- EFO_0001060
- Highest recorded phase
- 2
- Condition identifier
- EFO_0003095
- Highest recorded phase
- 2
- Condition identifier
- EFO_0006890
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005130
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0013209
- Highest recorded phase
- 2
- Hydrogen bond acceptors
- 9
- Hydrogen bond donors
- 3
- Polar surface area
- 153.42
- Calculated partition coefficient (ALogP)
- 1.38
- Calculated partition coefficient (XLogP)
- 1.6
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Rule-of-five violations
- 1
- Rotatable bonds
- 14
- Heavy atoms
- 38
- Molecular formula
- C26H36N6O6
- Monoisotopic mass
- 528.26963289
- Natural product
- No
- Recorded assays
- 7
- Active assays
- 2
Active assay types
- Confirmatory
Related records
Trials (3)
- A Study of TAK-227 in Healthy Adults
- Different Doses of ZED1227 vs. Placebo in NAFLD
- Evaluating the Efficacy and Tolerability of ZED1227 in Subjects With Non-responsive Celiac Disease